Polymers in drug delivery

Pillai, Omathanu; Panchagnula, Ramesh

doi:10.1016/s1367-5931(00)00227-1

Cited by 581 publications

(374 citation statements)

References 24 publications

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“…In recent years, considerable research efforts have been directed towards the development of safe and efficient drug delivery systems with the use of polymers as agents for the controlled release of drugs from various types of formulated products, such as tablets, implants, and adhesive strips etc. Evidence of the high degree of interest in the design of such dosage forms is provided by number of reviews [3][4][5] and books [6][7][8] that has been concerned with these subjects. The release of drugs, absorbed or encapsulated by polymer, involves their slow and controlled diffusion from or through polymeric material.…”

Section: Introductionmentioning

confidence: 99%

Sodium alginate/poly (ethylene oxide) blend hydrogel membranes for controlled release of valganciclovir hydrochloride

Mallikarjuna

Rao

Siraj

et al. 2012

Designed Monomers and Polymers

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Sodium alginate (SA) and poly (ethylene oxide) PEO blend membranes were prepared by solvent casting method for the controlled release of valganciclovir hydrochloride, an antiHIV drug. The prepared membranes were thin, flexible, smooth, and characterized by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimeter (DSC), X-ray diffraction (X-RD), scanning electron microscopy (SEM), and tensile strength measurement. FTIR was used to understand the formation of hydrogen bonding between SA and PEO. The DSC and X-RD studies were performed to understand the crystalline nature of drug after encapsulation into the membranes. SEM was used to study the surface morphology of the membranes. Tensile strength measurements revealed the mechanical strength of the membranes. In vitro release studies indicated a dependence of release rate on the extent of crosslinking, amount of drug loading, and the amount of PEO, but slow release rates was extended up to 12 h. Cumulative release data were fitted onto to an empirical equation to compute diffusional exponent (n), which indicated the nonFickian trend for drug release.

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Section: Introductionmentioning

confidence: 99%

Sodium alginate/poly (ethylene oxide) blend hydrogel membranes for controlled release of valganciclovir hydrochloride

Mallikarjuna

Rao

Siraj

et al. 2012

Designed Monomers and Polymers

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“…For polymer selection, in addition to its physicochemical characteristics, characterization of extensive biochemical characteristics and preclinical tests are required to demonstrate its reliability (Pillai and Panchagnula, 2001). …”

Section: Polymersmentioning

confidence: 99%

“…The physical properties of a polymer carrier, such as hydrophilicity, surface charge, permeability and diffusibility, biocompatibility with tissue and blood (Pillai and Panchagnula, 2001). …”

Section: Polymersmentioning

confidence: 99%

Gene Delivery Systems: Recent Progress in Viral and Non-Viral Therapy

Cevher¹,

Sezer²,

Çağlar³

2012

Recent Advances in Novel Drug Carrier Systems

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“…Different methods have been used to load drugs (or biological active substances) into polymer matrices, including co-precipitation, in-situ incorporation and adsorption [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] . In co-precipitation processes, the doped polymer beads are prepared through precipitation from a solution that contains both the drug and the polymer resin.…”

Section: Introductionmentioning

confidence: 99%

Adsorption of BSA (Bovine Serum Albuminum) and lysozyme on poly(vinyl acetate) particles

Santos¹,

Alves²,

Pinto³

2016

Polímeros

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SbstractPoly(vinyl acetate) (PVAc) particles find many uses in the biomedical field, including the use as particle embolizers. Particularly, embolizing particles can combine physical and chemical effects when they are doped with pharmaceuticals. For this reason, the adsorption of bovine serum albuminum (BSA) and lysozyme (used as model biomolecules) on PVAc particles produced through suspension polymerization is studied in the present manuscript in a broad range of pH values. It is shown that significant amounts of BSA and lysozyme can be adsorbed onto PVAc particles in the vicinities of the isoelectric point of the biomolecules (0.65mg of BSA and 1.0mg of lysozyme per g of PVAc), allowing for production of chemoembolizers through adsorption. Particularly, it is shown that lysozyme still presents residual activity after the adsorption process, which can constitute very important characteristic for real biomedical applications.

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Polymers in drug delivery

Cited by 581 publications

References 24 publications

Sodium alginate/poly (ethylene oxide) blend hydrogel membranes for controlled release of valganciclovir hydrochloride

Sodium alginate/poly (ethylene oxide) blend hydrogel membranes for controlled release of valganciclovir hydrochloride

Gene Delivery Systems: Recent Progress in Viral and Non-Viral Therapy

Adsorption of BSA (Bovine Serum Albuminum) and lysozyme on poly(vinyl acetate) particles

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