Polymers from 1‐Vinyl‐2‐(hydroxymethyl)imidazole in Water: Altering from UCST to LCST Behavior via <i>O</i>‐Ethylation

Meiswinkel, Georg; Ritter, Helmut

doi:10.1002/macp.201400064

Cited by 7 publications

(6 citation statements)

References 18 publications

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“…The turbidity declined slightly after heating the xylan ether solution, and did not change after subsequently cooling the samples. Temperature-induced phase separation with a lower or upper critical solution temperature (LCST or UCST), as frequently encountered for synthetic water-soluble polymers bearing hydroxyl groups [ 27 , 28 , 29 , 30 , 31 ], was not observed. Slight turbidity was also detected in alkaline or acidic solutions.…”

Section: Resultsmentioning

confidence: 99%

Preparation and Characterization of Water-Soluble Xylan Ethers

Hettrich

Drechsler²,

Loth

et al. 2017

Polymers

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Xylan is a predominant hemicellulose component that is found in plants and in some algae. This polysaccharide is made from units of xylose (a pentose sugar). One promising source of xylan is oat spelt. This feedstock was used for the synthesis of two xylan ethers. To achieve water soluble products, we prepared dihydroxypropyl xylan as a non-ionic ether on the one hand, and carboxymethyl xylan as an ionic derivative on the other hand. Different preparation methods like heterogeneous, pseudo-homogeneous, and homogeneous syntheses were compared. In the case of dihydroxypropyl xylan, the synthesis method did not significantly affect the degree of substitution (DS). In contrast, in the case of carboxymethyl xylan, clear differences of the DS values were found in dependence on the synthesis method. Xylan ethers with DS values of >1 could be obtained, which mostly show good water solubility. The synthesized ionic, as well as non-ionic, xylan ethers were soluble in water, even though the aqueous solutions showed slight turbidity. Nevertheless, stable, transparent, and stainable films could be prepared from aqueous solutions from carboxymethyl xylans.

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Section: Resultsmentioning

confidence: 99%

Preparation and Characterization of Water-Soluble Xylan Ethers

Hettrich

Drechsler²,

Loth

et al. 2017

Polymers

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“…For polymeric drug delivery systems discussed in this article, only water-based solvents are applicable. There exist a certain number of water-soluble polymers that exhibit a UCST behavior [18][19][20][21][22], i.e. the polymer becomes insoluble on cooling.…”

Section: Responsivity To Temperaturementioning

confidence: 99%

Smart polymers in drug delivery systems on crossroads: Which way deserves following?

Hrubý

Filippov

Štěpánek

2015

European Polymer Journal

115

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“…The solubility of polymers in water is related to hydrophobic and hydrophilic interactions and the formation of hydrogen bonds. For polymeric drug delivery systems, mainly aqueous solvents are used [38,39,40].…”

Section: Polymer Types Used In Preparing Co-delivery Systemsmentioning

confidence: 99%

Polymeric Co-Delivery Systems in Cancer Treatment: An Overview on Component Drugs’ Dosage Ratio Effect

et al. 2019

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Multiple factors are involved in the development of cancers and their effects on survival rate. Many are related to chemo-resistance of tumor cells. Thus, treatment with a single therapeutic agent is often inadequate for successful cancer therapy. Ideally, combination therapy inhibits tumor growth through multiple pathways by enhancing the performance of each individual therapy, often resulting in a synergistic effect. Polymeric nanoparticles prepared from block co-polymers have been a popular platform for co-delivery of combinations of drugs associated with the multiple functional compartments within such nanoparticles. Various polymeric nanoparticles have been applied to achieve enhanced therapeutic efficacy in cancer therapy. However, reported drug ratios used in such systems often vary widely. Thus, the same combination of drugs may result in very different therapeutic outcomes. In this review, we investigated polymeric co-delivery systems used in cancer treatment and the drug combinations used in these systems for synergistic anti-cancer effect. Development of polymeric co-delivery systems for a maximized therapeutic effect requires a deeper understanding of the optimal ratio among therapeutic agents and the natural heterogenicity of tumors.

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Polymers from 1‐Vinyl‐2‐(hydroxymethyl)imidazole in Water: Altering from UCST to LCST Behavior via O‐Ethylation

Cited by 7 publications

References 18 publications

Preparation and Characterization of Water-Soluble Xylan Ethers

Preparation and Characterization of Water-Soluble Xylan Ethers

Smart polymers in drug delivery systems on crossroads: Which way deserves following?

Polymeric Co-Delivery Systems in Cancer Treatment: An Overview on Component Drugs’ Dosage Ratio Effect

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