Smart polymers in drug delivery systems on crossroads: Which way deserves following?

Hrubý, Martin; Filippov, Sergey K.; Štěpánek, Petr

doi:10.1016/j.eurpolymj.2015.01.016

Cited by 113 publications

(57 citation statements)

References 189 publications

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“…Natural polymers are also preferred over synthetic one because of organized molecular structure and biocompatible characteristics [3,6]. Development of smart polymeric materials from natural materials has attracted wide attention for controlled drug release studies [7,8]. Smart materials are designed to respond favorably to various external stimuli such as pH, temperature and light by changing their properties [7,9,10].…”

Section: Introductionmentioning

confidence: 99%

“…Development of smart polymeric materials from natural materials has attracted wide attention for controlled drug release studies [7,8]. Smart materials are designed to respond favorably to various external stimuli such as pH, temperature and light by changing their properties [7,9,10]. The pH-sensitive polymers, in particular, have been given attention in recent years for various pharmaceutical applications [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis and characterization of new shellac–hydroxypropylmethylcellulose composite for pharmaceutical applications

Barik

Patnaik²,

Parhi

et al. 2017

Polym. Bull.

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A new pH-responsive carrier matrix was designed from combination of shellac (Sh), hydroxpropylmethylcellulose (HPMC) and acrylic acid (AA). Characterization of materials was done using various advanced instrumentation techniques. The kinetics of thermal decomposition of materials were studied and compared using Coats-Redfern (CR) and Kissinger-Akahira-Sunose (KAS) mathematical models. The Arrhenius equations for thermal decomposition of shellac and chemically modified shellac (Sh-HPMC-AA) were computed to be k = (3.4 9 10 21 ) e -159.9/RT and k = (141.8) e -19.6/RT s -1 , respectively. The pHresponsive characteristics of Sh-HPMC-AA shows 288% swelling ratio. Further, the controlled release of 5-amino salicylic acid (5-ASA) was studied in buffer medium and Fick's diffusion equation was applied for calculation of transport phenomenon. The enzymatic degradation study of Sh-HPMC-AA is also reported.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of new shellac–hydroxypropylmethylcellulose composite for pharmaceutical applications

Barik

Patnaik²,

Parhi

et al. 2017

Polym. Bull.

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“…9 According to the tumor extracellular and intracellular pH gradients, dual pH-responsive drug delivery systems which can respond to not only pH e but also endosome/lysosome pH have been developed and exhibit great superiority in controlled release and targeted delivery of drugs, which are expected to simultaneously promote drug accumulation at the tumor site via the enhanced permeability and retention (EPR) effect and facilitate the cell internalization and intracellular drug release, greatly enhancing the drug delivery efficacy. For example, the tumor extracellular environment is more acidic ( pH e 6.5) than blood and normal tissues ( pH 7.4), and the pH values of endosomes/ lysosomes are even lower at 5.0-5.5.…”

Section: Introductionmentioning

confidence: 99%

Dual acid-responsive supramolecular nanoparticles as new anticancer drug delivery systems

et al. 2016

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Considering the specific pH gradients of tumour microenvironments, a dual acid-responsive drug delivery system, which can respond to the tumor extracellular and intercellular pH stimuli, has been fabricated via simple host-guest recognition. Firstly, we synthesise 2,4,6-trimethoxybenzaldehyde modified dextran (Dex-TMBA) and mPEG-imine-β-cyclodextrin (PIC), respectively. And then, through the host-guest recognition between the cyclodextrin (CD) of PIC and the benzene ring of Dex-TMBA, a kind of dual acid-responsive supramolecular drug delivery system can be fabricated. Under neutral pH conditions, anticancer drugs can be loaded by forming supramolecular nanoparticles via the host-guest recognition. While, at tumor extracellular pH (∼6.8), the acid-labile benzoic-imine of PIC cleaves and the nanoparticles are amino positively charged to facilitate cell internalization. Subsequently, due to the hydrolysis of acetal bonds in Dex-TMBA under significantly increased acidity in subcellular compartments such as the endosomes (∼5.3), the loaded doxorubicin releases from the endocytosed drug delivery. This dual acid-responsive nanoparticles can efficiently load and release drugs, acting as drug delivery systems for enhancing anticancer efficiency.

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“…Drug molecules can be efficiently loaded in nanogels before or after crosslinking process [13][14][15]. Cleavable crosslinks (e.g., ester, acetal, ketal, disulfide, hydrazine, amide, and anhydride bonds) are inserted either in cross-linkers or polymeric chains for allowing degradation of the nanogels network [16][17][18]. Recently, the Diels-Alder (DA) click reaction between maleimide and furan has attracted much attention for the design of crosslinked nanogels, since they can be efficiently carried out in water at low temperature without any catalyst and side-products [19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Facile approach to prepare pH and redox-responsive nanogels via Diels-Alder click reaction

Le¹,

Cao²,

Tu³

et al. 2018

Express Polym. Lett.

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Abstract.A novel pH and redox responsive system of sub-100 nm nanogels was prepared by arm-first approach via DielsAlder click reaction. First, well-defined poly(ethylene glycol)-block-poly(styrene-alt-maleic anhydride) (PEG-b-PSM) was synthesized and subsequently functionalized with furfuryl amine, leading to the formation of the dual-functional block copolymer of PEG-b-PSMf. The furfuryl groups in the PSMf block were employed to incorporate a redox-responsive linkage and the carboxylic acid moieties generated through functionalization acted as a pH-responsive part. The Diels-Alder click reaction between a bismaleimide crosslinker and PEG-b-PSMf was conducted at 60°C, affording star-like nanogel structures. Doxorubicin, a model anticancer drug, was loaded into to the core of the nanogels primarily by the ionic interaction with carboxylates of core blocks and a highest drug loading capacity of 38.1% was obtained. Furthermore, the in vitro profile showed a low release percentage (11.2%) of DOX at PBS pH 7.4, whereas a burst release (62%) at pH 5.0 in the presence of 10 mM glutathione, indicating the effective pH and redox responsive characteristic of the PEG-b-PSMf nanogels.

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Smart polymers in drug delivery systems on crossroads: Which way deserves following?

Cited by 113 publications

References 189 publications

Synthesis and characterization of new shellac–hydroxypropylmethylcellulose composite for pharmaceutical applications

Synthesis and characterization of new shellac–hydroxypropylmethylcellulose composite for pharmaceutical applications

Dual acid-responsive supramolecular nanoparticles as new anticancer drug delivery systems

Facile approach to prepare pH and redox-responsive nanogels via Diels-Alder click reaction

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