Polymers for tissue engineering, medical devices, and regenerative medicine. Concise general review of recent studies

Jagur‐Grodzinski, J.

doi:10.1002/pat.729

Cited by 343 publications

(175 citation statements)

References 248 publications

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“…[1][2][3] The fundamental goal of tissue engineering is the development of biocompatible substitutes that will restore, maintain or improve tissue functions. PBSu is an aliphatic biodegradable thermoplastic polyester, which is synthesized through condensation polymerization of 1,4-butanediol and succinic acid.…”

Section: Introductionmentioning

confidence: 99%

Thermal degradation kinetics and decomposition mechanism of PBSu nanocomposites with silica-nanotubes and strontium hydroxyapatite nanorods

Roumeli

Chrissafis

Lioutas

et al. 2014

Phys. Chem. Chem. Phys.

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Novel poly(butylene succinate) (PBSu) nanocomposites containing 5 and 20 wt% mesoporous strontium hydroxyapatite nanorods (SrHNRs) and silica nanotubes (SiNTs) were prepared by melt-mixing. A systematic investigation of the thermal stability and decomposition kinetics of PBSu was performed using pyrolysis-gas chromatography-mass spectroscopy (Py-GC-MS) and thermogravimetry (TG). Thorough studies of evolving decomposition compounds along with the isoconversional and model-fitting analysis of mass loss data led to the proposal of a decomposition mechanism for PBSu. Moreover, the effects of SrHNRs and SiNTs on the thermal stability and decomposition kinetics of PBSu were also examined in detail. The complementary use of these techniques revealed that the incorporation of SiNTs in PBSu does not induce significant effects neither on its thermal stability nor on its decomposition mechanism. In contrast, the addition of SrHNRs resulted in the catalysis of the initial decomposition steps of PBSu and also in modified decomposition mechanisms and activation energies. The evolving gaseous products of PBSu and their evolution pattern in the SiNT nanocomposites were the same as in neat PBSu, while they were slightly modified for the SrHNR nanocomposites, confirming the findings from thermogravimetric analysis.

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Section: Introductionmentioning

confidence: 99%

Thermal degradation kinetics and decomposition mechanism of PBSu nanocomposites with silica-nanotubes and strontium hydroxyapatite nanorods

Roumeli

Chrissafis

Lioutas

et al. 2014

Phys. Chem. Chem. Phys.

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“…The chemical structure of both polymers and monomer composition of PHBV were determined by Proton Nuclear Magnetic Resonance ( 1 H NMR) [20]. Spectra were recorded at 25°C on a Bruker AM300 spectrometer.…”

Section: Biopolymer Characterizationmentioning

confidence: 99%

Antibacterial PHAs coating for titanium implants

Rodríguez-Contreras

García

Manero

et al. 2017

European Polymer Journal

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Biomaterial-associated infection is a serious complication of modern implantation surgery.Thus, the improvement of implant surfaces is required to avoid the first stage for biofilm formation, bacterial adhesion. The current research addresses this issue by developing drug delivery systems (DDS) consisting of antibiotic-loaded polyhydroxyalkanoates (PHAs) coatings on titanium implants. Dip-coating technique was used to achieve optimal coatings with biodegradable biopolyesters, polyhydroxybutyrate (PHB) and its copolymer, polyhydroxybutyrate-co-hydroxyvalerate (PHBV). The coatings were completely characterized (wettability, topography, thickness and roughness), and studies of drug delivery, toxicity, antibacterial effect, and cell adhesion were performed. For both of biopolymers, surfaces were partially covered with 1 and 3 immersions, while with 6, they were completely covered. Although both antibiotic-loaded biopolymer coatings assure the protection against bacteria populations, PHBV coatings are closer to the desired release profile; its faster degradation provides for a greater and more stable drug release for a given period of time compared to PHB coatings. The use of coatings with different drug concentration per layer results in more controlled and homogeneous releases. The DDS designed not only assure toavoid the first stage of bacterial adhesion, but also their proliferation and biofilm formation, since the coatings degrade with time under physiological conditions, guaranteeing a prolonged drug release.

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“…Among these, polymer based materials have confirmed to be a good choice as biomaterials in tissue engineering applications, smart prostheses, and sensors, among others [1,2]. In the last years, the potential of electro active polymers has been recognized for biomedical applications due to its ability to convert mechanical, thermal, or magnetic signals into electrical ones.…”

Section: Introductionmentioning

confidence: 99%

Osteoblast, fibroblast and in vivo biological response to poly(vinylidene fluoride) based composite materials

Costa

Ribeiro

Lopes

et al. 2012

J Mater Sci: Mater Med

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Electroactive materials can be taken to advantage for the development of sensors and actuators as well as for novel tissue engineering strategies. Composites based on poly(vinylidene fluoride), PVDF, have been evaluated with respect to their biological response. Cell viability and proliferation were performed in vitro both with Mesenchymal Stem Cells differentiated to osteoblasts and Human Fibroblast Foreskin 1. In vivo tests were also performed using 6-weekold C57Bl/6 mice. It was concluded that zeolite and clay composites are biocompatible materials promoting cell response and not showing in vivo pro-inflammatory effects which renders both of them attractive for biological applications and tissue engineering, opening interesting perspectives to development of scaffolds from these composites. Ferrite and silver nanoparticle composites decrease osteoblast cell viability and carbon nanotubes decrease fibroblast viability. Further, carbon nanotube composites result in a significant increase in local vascularization accompanied an increase of inflammatory markers after implantation.

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Polymers for tissue engineering, medical devices, and regenerative medicine. Concise general review of recent studies

Cited by 343 publications

References 248 publications

Thermal degradation kinetics and decomposition mechanism of PBSu nanocomposites with silica-nanotubes and strontium hydroxyapatite nanorods

Thermal degradation kinetics and decomposition mechanism of PBSu nanocomposites with silica-nanotubes and strontium hydroxyapatite nanorods

Antibacterial PHAs coating for titanium implants

Osteoblast, fibroblast and in vivo biological response to poly(vinylidene fluoride) based composite materials

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