Polymers for Mucoadhesive Drug Delivery System: A Current Status

Functional physico-chemical, ex vivo permeation and cell viability characterization of omeprazole loaded buccal films for paediatric drug delivery

“…Hydration and presence of salts have been reported among factors that affect the mucoadhesion of polymer based systems for mucosal applications (Salamat-Miller et al, 2005;Asane et al, 2008;Roy et al, 2009). A slower rate of hydration and swelling of the 17 film, in SS due to presence of extra salts, will therefore slow down the formation of such 400 physical entanglements between the polymer chains and the chains of the gelatine, with resultant decrease in adhesive properties, whilst the reverse was true for gelatine equilibrated with PBS.…”

Application of an anionic polymer in the formulation of floating tablets containing an alkaline model drug

“…11,14,15 The floating properties of the tablets may be ascribed to the properties of the PA, i.e., to the hydrogen bonding groups, strong anionic charges and high molecular weight. 26 PA resins are hydrophilic substances that are insoluble in water and swell when dispersed in water to form colloidal suspensions. When they come into contact with water, PA polymers increase their original volume and diameter.…”

Mucoadhesive Polymer Hyaluronan as Biodegradable Cationic/Zwitterionic-Drug Delivery Vehicle

“…The formed aggregates of MW ~ 10 8 g·mol -1 are deposited within the collagen framework, without which interaction the proteoglycans would not be retained in cartilage. Mucoadhesive polymers were used in pharmaceutical formulations to release drugs in mucosas [gastrointestinal (GI)/vaginal tracts, ocular mucosa, bucal/nasal cavity] [36]. They fix to mucus through mechanisms (molecular interpenetration, van der Waals forces, hydrophobic interactions, electrostatic forces, H-bonds) increasing drug bioavailability [37][38][39][40].…”