Polymers based on polyoxypropylene glycol, diisocyanate and ethylene glycol monomethacrylate

Spirin, Yu.L.; Lipatov, Yu.S.; Magdinets, V.V.; Sergeyeva, L.M.; Kercha, Yu.Yu.; SAVCHENKO, T.; Vilenskaya, L.N.

doi:10.1016/0032-3950(68)90088-9

Cited by 15 publications

(8 citation statements)

References 4 publications

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“…Aflatoxin B1 (AFB1), aflatoxin G2 (AFG2), ochratoxin A (OTA), 1-allylpiperazine (AP), 2-(diethylamino)ethylmethacrylate (DEAEM), dimethylformamide (DMF), hydroxyethylmethacrylate (HEMA), polyethylene glycol MM 20,000 (PEG 20,000), triethylene glycol dimethacrylate, 4-vinylpyridine and zearalenone were purchased from Sigma-Aldrich (St. Louis, MO, USA). Oligourethaneacrylate (OUA) was obtained according to a previous method [33] and kindly provided by Dr. V.F. Matyushov.…”

Section: Methodsmentioning

confidence: 99%

Sensor Based on Molecularly Imprinted Polymer Membranes and Smartphone for Detection of Fusarium Contamination in Cereals

Sergeyeva

Yarynka

Dubey

et al. 2020

Sensors

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The combination of the generic mobile technology and inherent stability, versatility and cost-effectiveness of the synthetic receptors allows producing optical sensors for potentially any analyte of interest, and, therefore, to qualify as a platform technology for a fast routine analysis of a large number of contaminated samples. To support this statement, we present here a novel miniature sensor based on a combination of molecularly imprinted polymer (MIP) membranes and a smartphone, which could be used for the point-of-care detection of an important food contaminant, oestrogen-like toxin zearalenone associated with Fusarium contamination of cereals. The detection is based on registration of natural fluorescence of zearalenone using a digital smartphone camera after it binds to the sensor recognition element. The recorded image is further processed using a mobile application. It shows here a first example of the zearalenone-specific MIP membranes synthesised in situ using “dummy template”-based approach with cyclododecyl 2, 4-dihydroxybenzoate as the template and 1-allylpiperazine as a functional monomer. The novel smartphone sensor system based on optimized MIP membranes provides zearalenone detection in cereal samples within the range of 1–10 µg mL−1 demonstrating a detection limit of 1 µg mL−1 in a direct sensing mode. In order to reach the level of sensitivity required for practical application, a competitive sensing mode is also developed. It is based on application of a highly-fluorescent structural analogue of zearalenone (2-[(pyrene-l-carbonyl) amino]ethyl 2,4-dihydroxybenzoate) which is capable to compete with the target mycotoxin for the binding to zearalenone-selective sites in the membrane’s structure. The competitive mode increases 100 times the sensor’s sensitivity and allows detecting zearalenone at 10 ng mL−1. The linear dynamic range in this case comprised 10–100 ng mL−1. The sensor system is tested and found effective for zearalenone detection in maize, wheat and rye flour samples both spiked and naturally contaminated. The developed MIP membrane-based smartphone sensor system is an example of a novel, inexpensive tool for food quality analysis, which is portable and can be used for the “field” measurements and easily translated into the practice.

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Section: Methodsmentioning

confidence: 99%

Sensor Based on Molecularly Imprinted Polymer Membranes and Smartphone for Detection of Fusarium Contamination in Cereals

Sergeyeva

Yarynka

Dubey

et al. 2020

Sensors

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“…Oligourethane acrylate (OUA) was donated by the Institute of Macromolecular Chemistry (Ukraine) and synthesized according to Spirin et al (1968) and German patent 1085671 (1961).…”

Section: Methodsmentioning

confidence: 99%

Conductance based sensing and analysis of soluble phosphates in wastewater

Warwick

Guerreiro

Gómez‐Caballero

et al. 2014

Biosensors and Bioelectronics

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The current standard method used for measuring soluble phosphate in environmental water samples is based on a colourimetric approach, developed in the early 1960s. In order to provide an alternative, label free sensing solution, a molecularly imprinted polymer (MIP) was designed to function as a phosphate receptor. A combination of functional monomer (N-allylthiourea), cross-linker and monomer/template ratios were optimised in order to maximise the binding capacity for phosphate. When produced in membrane format, the MIP's ability to produce a reversible change in conductance in the presence of phosphate was explored for fabrication of a sensor which was able to selectively detect the presence of phosphate compared to sulphate, nitrate and chloride. In wastewater samples the sensor had a limit of detection of 0.16 mg P/l, and a linear range between 0.66 and 8 mg P/l. This is below the minimum monitoring level (1 mg P/l) as required by current legislation for wastewater discharges, making the sensor as developed promising for direct quantification of phosphate in environmental monitoring applications.

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“…Ethyl-2-oxocyclopentanecarboxylate was purchased from (Acros, UK). Oligourethaneacrylate (OUA) was synthesised as described earlier [30]. All the other reagents of analytical grade were obtained from Sigma-Aldrich (USA) and used without additional purification.…”

Section: Materials Aflatoxin B1 (Afb1) Aflatoxin B2 (Afb2) and Aflmentioning

confidence: 99%

Development of a smartphone-based biomimetic sensor for aflatoxin B1 detection using molecularly imprinted polymer membranes

Sergeyeva

Yarynka

Piletska

et al. 2019

Talanta

106

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A novel smartphone-based optical biomimetic sensor based on free-standing molecularly imprinted polymer (MIP) membranes was developed for rapid and sensitive point-of-care detection of aflatoxin B1. The developed MIP membranes were capable of selective recognition of the target analyte and, at the same time, of generation of a fluorimetric sensor response, which could be registered using the camera of a smartphone and analysed using image analysis. The developed system provides a possibility of synchronous detection of aflatoxin B1 in 96 channels. UV irradiation of aflatoxin B1, selectively bound by the MIP membranes from the analysed samples, initiated fluorescence of aflatoxin B1 with intensity directly proportional to its concentration. The composition of the MIP membranes used as a recognition element was optimised taking into account data of computational modelling. Two functional monomers (2-acrylamido-2-methyl-1-propansulfonic acid and acrylamide) were identified as optimal for the formation of aflatoxin B1-selective binding sites in the structure of the MIP membranes. Working characteristics of the smartphone-based sensor system were also estimated. The influence of pH and of buffer and NaCl concentrations on the smartphonebased sensor responses were studied. High selectivity of the developed sensor system towards aflatoxin B1 was confirmed in experiments with close structural analogues of the target analyteaflatoxin G2, and ochratoxin A. The detection limit for aflatoxin B1 using the smartphone-based sensor systems was found to be 20 ng mL-1 for the sensor based on MIP membranes synthesised with acrylamide as a functional monomer. The storage stability of the recognition elements of the developed sensors was estimated as one year when stored at 22°C. The possibility to detect the aflatoxin B1 in contaminated food samples was shown. The MIP-membrane-based sensor system provided a convenient point-of-care approach in food safety testing.

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Polymers based on polyoxypropylene glycol, diisocyanate and ethylene glycol monomethacrylate

Cited by 15 publications

References 4 publications

Sensor Based on Molecularly Imprinted Polymer Membranes and Smartphone for Detection of Fusarium Contamination in Cereals

Sensor Based on Molecularly Imprinted Polymer Membranes and Smartphone for Detection of Fusarium Contamination in Cereals

Conductance based sensing and analysis of soluble phosphates in wastewater

Development of a smartphone-based biomimetic sensor for aflatoxin B1 detection using molecularly imprinted polymer membranes

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