Polymers and group interaction. VIII. Synthesis of a styrene–amino acid copolymer

Goethals, E.; Smets, G.

doi:10.1002/pol.1959.1204013617

Cited by 11 publications

(2 citation statements)

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“…Most interesting results were obtained by E. Goethals in Belgium and J. Kennedy in USA (1,2). Polymerisation of such monomers results in graft copolymers and other types of block sequences in macromolecular chains.…”

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confidence: 69%

The chemistry of macromonomers based on physiologically active substances and some problems of the synthesis of polymers for biomedical applications

Platè¹,

Валуев²,

Chupov³

1984

Pure and Applied Chemistry

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-In this paper an approach to the synthesis of macronnomers is described which permits to convert into reactive polymerisable species a wide circle of physiologically active substances without noticeable change of their activity. This approach which we developed and studied since 1975 at Moscow University gave us a chance to create a whole new range of macromonomers which were found to be capable of linear, three--dimensional and graft polymerisation. Products of these reactions are soluble physiologically active substances, hydrogels with immobilized physiologically active species, sorbents for biospecific chromatography, coatings which increase blood compatibility of polymeric prosthetic devices, etc.Few years ago, mainly due to efforts of chemists studying ionic polymerisation processes, a new branch of monomer chemistry arose, namely, chemistry of macromonomers, i.e., organic species of rather high molecular mass (5000-10000) having the reactive group (double bond or cycle) at the end of the molecule. Most interesting results were obtained by E. Goethals in Belgium and J. Kennedy in USA (1,2). Polymerisation of such monomers results in graft copolymers and other types of block sequences in macromolecular chains.This new branch of "big" monomers is very attractive, in particular, by giving a chance to study the reactivity of the double bond (or cycle) which are under the influence of conformational rearrangements of the macromolecule itself.First publications on the synthesis of physiologically active macromonomers in the middle of the 70-ies were related with immobilization of enzymes in polymeric hydrogels. The driving force for this research was the fact that, in the majority of methods, to carry out this process based on the interaction of physiologically active species (FAS) with a pizeactivated polymer matrix, there was no big chance to maintain the biological activity of immobilized FAS. The reason for that, as shown in Ref. 3, is the necessity to adapt FAS macromolecules to the structure of the polymer matrix which needed essential conformational changes of FAS. However, another approach could be developed when the polymer matrix is itself adopted to the macromolecules of FAS. This becomes possible if the formation of the matrix is carried out, for instance, simultaneously with the immobilization of FAS, i.e., the copolymerisation of an unsaturated derivative of FAS with corresponding monomers takes place:1351

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mentioning

confidence: 69%

The chemistry of macromonomers based on physiologically active substances and some problems of the synthesis of polymers for biomedical applications

Platè¹,

Валуев²,

Chupov³

1984

Pure and Applied Chemistry

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“…Finally, it should be noted that styrene-maleic anhydride copolymers can be converted into the corresponding styrene-N-substituted maleimide copolymers by treatment with primary aminesl669 167 (22). Elemental analyses and the infrared spectra of the derived polymers indicate that the transformation occurs quantitatively.…”

Section: Other Polymer Transformations Yielding Polywleric Modelsmentioning

confidence: 99%

The chemical modification of polymers for analytical purposes

Harwood

1968

Angew. Makromol. Chem.

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When it is possible to convert one polymer quantitatively into another, the derived polymer can sometimes be studied to obtain information about the original polymer. In other instances, the derived polymer can serve as a reference material for use in the development of polymer characterization procedures. This paper reviews the use of such techniques in studies on branching and stereoregularity in homopolymers and in studies on sequence distribution in copolymers. The reactions covered include hydrolysis, ammonolysis, alcoholysis, esterification, transesterification and the hydrogenation of polyhalocarbons and unsaturated polyhydrocarbons. In addition, recent studies on cyclization reactions in polymers are surveyed. Such studies can provide information about sequence distribution in copolymers. ZUSAMMENFASSUNG :Derivate von Polymeren, die durch quantitative Umwandlung entstanden sind, konnen in gewissen Fallen dazu benutzt werden, die Eigenschaften des Ausgangspolymeren zu untersuchen. Das Polymerderivat kann auch als Bezugssubstanz bei der Entwicklung von Methoden zur Charakterisierung von Polymeren dienen. I n dieser Arbeit wird uber die Anwendung derartiger Methoden fur Untersuchungen uber die Verzweigung und Stereoregularitiit von Homopolymeren und die Sequenzverteilung von Copolymeren berichtet. Es werden verschiedene Reaktionen beschrieben, darunter Hydrolyse, Ammonolyse, Alkoholpse, Veresterung, Umesterung und die Hydrierung von Polyhalogenkohlenwasserstoffen und ungesatt,igten Polykohlenwasserstoffen. Weiterhin wird ein uberblick uber neuere Ringschlufireaktionen an Polymeren gegeben. Derartige Reaktionen konnen fur Untersuchungen der Sequenzverteilung von Copolymeren von Wichtigkeit sein.

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