Polymerization-induced self-assembly for the fabrication of polymeric nano-objects with enhanced structural stability by cross-linking

Abstract

This review discusses the strategies of core-cross-linking in most of the PISA literatures (including post-polymerization cross-linking, photo-cross-linking and in situ cross-linking) and the applications of the cross-linked nano-objects.

In situ SAXS studies of a prototypical RAFT aqueous dispersion polymerization formulation: monitoring the evolution in copolymer morphology during polymerization-induced self-assembly

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Within the last two decades, polymerization-induced self-assembly (PISA) has become widely recognized as a powerful platform technology for the efficient synthesis of a wide range of block copolymer nanoparticles of controllable size and morphology. [19][20][21][22][23][24][25][26][27][28] In essence, PISA involves growing a second block from a soluble precursor block in a suitable solvent. As the second block grows, it becomes insoluble at some critical chain length, which leads to in situ self-assembly to form nascent sterically-stabilized diblock copolymer nanoparticles (or micelles).…”

Orthogonal synthesis and modification of polymer materials

“…The main advantages for this method are attributed to enhanced scalability and morphological tunability when compared with traditional self‐assembly limited to dilute concentrations 218–220 . Furthermore, structural stability of polymer NPs over ranges of concentrations, pH, temperature, and so forth is required for broad applications such as drug delivery, Pickering emulsifiers and catalytic nanoreactors 212,221,222 . In situ crosslinking using monomers containing multiple vinyl groups can be advantageous over the post‐polymerization crosslinking methods since the stabilized NPs can be directly prepared.…”

Block copolymer solution self‐assembly: Recent advances, emerging trends, and applications

“…One of the most intriguing features of such particles is that they can undergo order–order and order–disorder transitions in response to the external stimuli, thus altering the packing parameter and the self‐organized morphology post‐synthesis, and eventually leading to transitions between different morphologies 98,99 . Finally, these nano‐objects can even be further stabilized by means of cross‐linking, thus ensuring their structural integrity and enhancing their bioapplication capability 99,109,112 …”

“…98,99 Finally, these nano-objects can even be further stabilized by means of cross-linking, thus ensuring their structural integrity and enhancing their bioapplication capability. 99,109,112…”