Polymeric supernucleophilic pyridine catalysts: homogeneous esterolysis of p-nitrophenyl esters

3-[6-(4-Methoxyphenyl)-2-methylpyrimidin-4-yl]-2-(4-methylpiperazin-1-yl)quinoline

“…The pyrimidine nucleus also plays an important role in the medicinal chemistry and is reported to possess a broad spectrum of biological activities such as antimicrobial, anti-inflammatory, anthelmintic, anti HIV, antitubercular properties (Prasad et al, 2008;Vaidya & Mathias 2005;Virsodia et al, 2008). In a continuation of structural studies of these derivatives (Sharma et al, 2017;Kaiser et al, 2009;Prasath et al, 2010) the title compound was investigated.…”

Effects of Polymer Architecture and Nanoenvironment in Acylation Reactions Employing Dendritic (Dialkylamino)pyridine Catalysts

“…28,[33][34] The pyrrolidine groups of the cyclocopolymer were reacted with an isopropylidene-protected bis(hydroxymethyl)propionic acid anhydride. 22,32 Subsequent deprotection of the 1,3-diols under acidic conditions activates the end groups for further dendrimer growth.…”

A Synthetic P-Nitrophenyl Esterase with Remarkable Substrate Selectivity

“…COO pH > 7 O2,N 1,n=2, 6, 8, 10,12,14,16,18 important processes. Most studies have focused on increasing catalyst efficiency to bring activity of synthetic catalyst to levels afforded by relevant enzymes.…”

“…1) of which 4-(dimethylamino)pyridine, 2, is best known,are such highly reactive nucleophilic catalysts in aprotic solvents that they are often referred to as "super-nucleophiles" (13,14,(21)(22)(23) (14) described a second particularly active polymeric form of DAAP. poly(4-(diallylamino)pyridine, 5, that exhibited increasing activity toward variants of 1 with increasing length of alkanoate chain ( C2 -C12).…”

“…Duplication of the efficiency and selectivity of enzymic catalysis with synthetic materials has been pursued by many investigators for several decades (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Studies directed toward understanding the enhancement of amide and ester hydrolysis have frequently utilized pnitrophenyl esters, 1, of aliphatic carboxylic acids as substrates.…”