In the title molecule, C 24 H 25 N 3 O 2 , the piperazine ring adopts a chair conformation. The methoxyphenyl-substituted ring makes a dihedral angle of 6.79 (5) with the quinoline ring system. In the crystal, molecules are consolidated in the crystal packing by a combination of weak C-HÁ Á ÁN and C-HÁ Á ÁO interactions. -stacking interactions also occur.
Structure descriptionQuinoline derivatives find importance owing to their wide occurrence in natural products and in biologically active compounds (Markees et al., 1970;Campbell et al., 1988;Kalluraya & Sreenivasa, 1998). Quinoline chalcone analogues have also attracted significant attention as a result of their bio-activity, e.g. anti-plasmodial, anti-microbial, anti-malarial and anti-cancer (Dimmock et al., 1999;Wu et al., 2006).In the molecule of the title compound, (Fig. 1), bond lengths are in normal ranges and are comparable with related structures (Kaiser et al., 2009;Prasath et al., 2010Prasath et al., , 2011. The piperazine ring adopts a chair conformation with best mirror plane passing through atoms C20 and C22 [asymmetry parameter ÁC s (C20) = 2/3] and the best twofold rotational axis bisecting the C22-C23 and C20-C21 bonds [asymmetry parameter ÁC 2 (C22-C23) = 0.43; Duax & Norton, 1975). The quinoline ring system is essentially planar with a maximum deviation of 0.0384 (1) Å for atom C17. The methoxyphenylsubstituted ring makes a dihedral angle of 6.79 (5) with the quinoline ring system. In the crystal, molecules are consolidated in the crystal packing by a combination of weak C-HÁ Á ÁN and C-HÁ Á ÁO interactions (Table 1, Fig. 2). The crystal structure also features -stacking interactions observed between the (C11-C13/C18/N1/C19) ring and the methoxyphenyl-substituted ring [centroid-centroid separation = 3.680 (1) Å , interplanar spacing = 3.350 Å and centroid shift = 1.52 Å ] and the benzene ring (C13-
In the title compound, C26H27N5O, the piperazine ring adopts a chair conformation. The pyrimidine ring makes a dihedral angle of 1.5 (1)° with the methoxyphenyl ring and 33.1 (1)° with the quinoline ring system. In the crystal, molecules are consolidated in the crystal packing by weak C—H...π interactions and π–π stacking interactions.
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