Polymeric Recrystallized Agglomerates of Cefuroxime Axetil Prepared by Emulsion Solvent Diffusion Technique

Yadav, VB; Yadav, AV

doi:10.4314/tjpr.v8i4.45225

Cited by 10 publications

(9 citation statements)

References 14 publications

(6 reference statements)

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“…The two most commonly used techniques of spherical crystallization are wet spherical agglomeration method (WSA), quasi-emulsion solvent diffusion method (QESD, Transient emulsion) 10 . But there are two extensions of these techniques, ammonia diffusion system (ADS) and crystalco-agglomeration technique (CCA) 12,13. Another technique of this process is Neutralization, where first fine crystals form by neutralization then it will agglomerate by the help of a bridging liquid 14 .…”

Section: Methods Of Spherical Crystallizationmentioning

confidence: 99%

Spherical Crystallization: A Tool to Improve the Physicochemical Properties of APIs

Thenge¹,

Chandak²,

Adhao³

2020

Asian J Pharm Res Dev

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A greater challenge in solid dosage formulation is the development of spherical agglomerates which increases the solubility and bioavailability of the drug. Spherical crystallization is “An agglomeration process that transforms crystals directly into compact spherical forms during the crystallization process.” Spherical crystallization is the novel agglomeration technique that can transform directly the fine crystals produced in the crystallization process into a spherical shape. Direct Compression of powders is simple and easy way of making tablets. In direct compression of Good Compressibility and flowability plays a major role. Spherical crystallization methods are very useful methods in which the drug crystals are modified using different solvents to directly compressible agglomerates. which cost effective and time saving. The different Techniques discussed are Crystallization method, Solvent crystallization method, Quasi- emulsion diffusion method, Ammonia Diffusion method, neutralization method, and solvent agglomeration technique. This article gives a detailed and comprehensive review about different techniques, its advantages, mechanism and application of Spherical agglomeration Technique along with its Evaluation and Characterization methods.

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Section: Methods Of Spherical Crystallizationmentioning

confidence: 99%

Spherical Crystallization: A Tool to Improve the Physicochemical Properties of APIs

Thenge¹,

Chandak²,

Adhao³

2020

Asian J Pharm Res Dev

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“…The results of solubility study revealed that solubility increases with increase in concentration of carrier. Reasons for this might be improved wettability and porosity, decreased primary particle size and partial amorphization of drug in dispersed state compared to raw crystals of CC 26 . Enhanced solubility and dissolution rate of CC in SD prepared using PVP could be attributed to the chemical structure of highly water soluble PVP.…”

Section: Solubility Determinationmentioning

confidence: 99%

Untitled

2014

IJPSR

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The aim of the present study was to characterize solid dispersion (SD) of Candesartan cilexetil (CC) prepared with polyvinyl pyrrolidone K30 (PVP) for enhancing its solubility and bioavailability. The SDs of Candesartan was prepared by solvent evaporation method. The prepared SDs were evaluated for saturation solubility, practical yield, drug content, and in vitro dissolution study, IR-Spectroscopy, X-ray powder diffractometry (XRD) and differential scanning calorimetry (DSC). The dissolution rates of SDs prepared with PVP was much faster than the pure CC and physical mixtures (PM). The data from the XRD showed that drug was crystalline in bulk and in PM. Significant change in melting peak in DSC thermograms of SDs revealed amorphization. SDs showed marked increase in the solubility of CC with increasing carrier concentration. At the highest ratio of carriers the drug solubility was enhanced about 6-folds for SD in PVP. The dissolution rate was increased with increasing carrier concentration at pH 6.5. XRD data revealed a remarkable interaction between the CC and the carrier that enhanced drug dissolution. The 1:4 ratios were sufficient for conversion of Candesartan to amorphous form. INTRODUCTION: In pharmaceutical Candesartan cilexetil (CC) is marketed as the angiotensin II receptor antagonist; CC is indicated for the treatment of hypertension and congestive heart failure. Thus, while ACE inhibitors are still considered first-line therapy in research and development an increasing number of drug candidates are poorly water soluble. The solubility and dissolution may become rate limiting factors for effective bioavailability of such drugs upon oral administration 1 .

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“…bridging liquid; and the last one is immiscible with the drug substance i.e. bad solvent 32 . The spherical crystallization has been applied to several drugs, and it has been found that the product properties are quite sensitive to the amount of the bridging liquid 15 .…”

Section: Techniques Of Spherical Crystallizationmentioning

confidence: 99%

Pharmaceutical Overview of Spherical Crystallization

Bathe

Chourey

Khobragade

et al. 2012

Int J of Biomed & Adv Res

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Spherical crystallization is a particle design technique, by which crystallization and agglomeration can be carried out simultaneously in one step and which has been successfully utilized for improvement of flowability, compactability and bio-availability of crystalline drugs. General methods of spherical crystallization are spherical agglomeration, emulsion solvent diffusion and ammonia diffusion method. The principle steps involved in the process of spherical crystallization are flocculation zone, zero growth zone, fast growth zone and constant size zone. Spherical crystallization is having wide applications in pharmaceuticals like improvement of flowability and compressibility of poorly compressible drugs, masking bitter taste of drugs and improving the solubility and dissolution rate of poorly soluble drug.

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Polymeric Recrystallized Agglomerates of Cefuroxime Axetil Prepared by Emulsion Solvent Diffusion Technique

Abstract: Purpose: To study the effect of different polymers on the solubility and dissolution rate of cefuroxime axetil (CFU) prepared by emulsion solvent diffusion (ESD

Cited by 10 publications

References 14 publications

Spherical Crystallization: A Tool to Improve the Physicochemical Properties of APIs

Spherical Crystallization: A Tool to Improve the Physicochemical Properties of APIs

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Pharmaceutical Overview of Spherical Crystallization

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