Spherical Crystallization: A Tool to Improve the Physicochemical Properties of APIs

Abstract

A greater challenge in solid dosage formulation is the development of spherical agglomerates which increases the solubility and bioavailability of the drug. Spherical crystallization is “An agglomeration process that transforms crystals directly into compact spherical forms during the crystallization process.” Spherical crystallization is the novel agglomeration technique that can transform directly the fine crystals produced in the crystallization process into a spherical shape. Direct Compression of powders is simple and easy way of making tablets. In direct compression of Good Compressibility and flowability plays a major role. Spherical crystallization methods are very useful methods in which the drug crystals are modified using different solvents to directly compressible agglomerates. which cost effective and time saving. The different Techniques discussed are Crystallization method, Solvent crystallization method, Quasi- emulsion diffusion method, Ammonia Diffusion method, neutralization method, and solvent agglomeration technique. This article gives a detailed and comprehensive review about different techniques, its advantages, mechanism and application of Spherical agglomeration Technique along with its Evaluation and Characterization methods.

Untitled

“…The association of molecules in a solid state, which might impact the physical and chemical properties of the medicinal substance, is referenced by the crystal form. [8] The effectiveness of a dose shape may depend on the crystal structure, especially for substances that naturally impede drug delivery. [9] Pharmaceutical drug manufacture and storage may result in changes to a drug's crystal structure, which can impact the medication's solubility, dissolution profile, and bioavailability.…”

“…For instance, to increase their soluble nature and bioavailability in the alkaline environment of the small intestine, acidic substances may be prepared as salts containing significant counterions. [8] Other methods may be used in addition to pH modification to increase the bioavailability of oral medications that are poorly soluble. These techniques consist of solid dispersion, lipid formation, co-crystal creation, and nanosuspension.…”

“…One useful approach for resolving solubility problems in pharmaceutical formulations is physical change. [8] Particle size reduction, co-crystal formation, amorphous formulation, lipid formulation, and solid dispersion are among the alterations that may be made. Happens.…”