volume 277, issue 1-2, P119-131 2004
DOI: 10.1016/j.ijpharm.2003.07.016
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K Hoste, K De Winne, E Schacht

Abstract: In 1975 Prof. H. Ringsdorf proposed a model for rational design of polymeric prodrugs [J. Polym. Sci. Symp. 51 (1975) 135]. The model has been the most important basis for research in the field, since it was the first model that took into account both the chemical and biological aspects needed for the design of polymeric prodrugs. This paper deals with the most important properties that were discovered by designing polymeric prodrugs: prolongation of action of the drug, controlled release of the drug, passive …

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