Polymeric porphyrins as new photocatalysts in photodynamic therapy of cancer

Abstract

Photodynamic therapy and diagnosis (PDT) is described as an efficient clinical method for the treatment of cancer patients using hematoporphyrin derivative (Hpd) as sensitizer. Newly developed metal‐containing porphyrin type compounds are potential agents for PDT. A concept for covalently bound polymeric metal‐containing or metal‐free sensitizers is discussed. First results of these polymeric sensitizers are reported from in vivo experiments. High tumor accumulation up to 30% was observed. Results of fluorescence diagnosis are shown.

Photochemical stability of various porphyrins in solution and as thin film electrodes

“…This concentration is comparable with those used for the investigation of sensitizer activities (photoredox or photo energy transfer reactions). 1*21 [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] The stability was determined by the decay in the intensity of the main absorption band (Q-band for 1, 3, 5 or a Soret-band for 2,4, 6) in the visible region. The measurements were conducted in air or under argon either in the dark or under illumination (A = 350-850 nm, 20 mW cm--2).…”

Applications of Microwave in Organic Synthesis: An Improved One-step Synthesis of Metallophthalocyanines and a New Modified Microwave Oven for Dry Reactions

“…For example, phthalocyanines are used in laser-beam printers and photocopiers [ 3 ], in non linear optics [ 4 ], as liquid crystals [ 5 ], as photosensitizers [ 6 ], in optical data storage [ 7 ], as gas sensors [ 8 ], as electrochromic substances [ 9 ] and as carrier generation materials in near infrared (NIR) [ 10 ]. Many substituted derivatives of phthalocyanines behave like active components in various redox processes, for example, in photoredox reactions and photooxidations in solution [ 2 , 11 , 12 ] and for photodynamic cancer therapy [ 2 , 13 , 14 ].…”