Polymeric nanoparticles-embedded organogel for roxithromycin delivery to hair follicles

Nanoengineered Drug Delivery Systems for Enhancing Antibiotic Therapy

“…Roxithromycin NPs (size 300 nm), using PCL as a polymer, were prepared using an emulsion solvent evaporation method and were embedded in pluronic‐lecithin organogel (PLO). In vitro human skin penetration studies revealed that it is possible to preferentially target the pilosebaceous unit with the polymeric NPs, whereas the PLO formulation did not promote follicular penetration more efficiently than suspension of NPs . Therefore, antibiotic‐loaded PNPs can now also be entrapped into a gel for facilitating transdermal delivery.…”

Anti-PDGF receptor β antibody-conjugated squarticles loaded with minoxidil for alopecia treatment by targeting hair follicles and dermal papilla cells

“…28 Efficient skin delivery is dependent upon the partitioning of the drug from the vehicle to the sebum. 29 According to the data of MXD permeation via sebum-removed skin, MXD in solution showed a limited ability to interact with sebum since the drug penetration was significantly increased in the absence of sebum. This phenomenon could be ameliorated by using squarticles as the drug carriers.…”

Applications and limitations of lipid nanoparticles in dermal and transdermal drug delivery via the follicular route

“…Küchler et al identified the lipophilicity of the lipid matrix 103 and the compound as the promoters for partition into skin lipids 104 [25]. The two different mechanistic approaches -either surface 105 localization or interactions with skin lipids -are also discussed 106 for the liquid lipid component of NLC, e.g., the permeation of genis- 107 tein from NLC was enhanced potentially due to lipid switches of 108 the formulation and skin as the NLC allow for an elevated mobility 109 of the oil [26], while the increased penetration of Q10 was 110 explained by the superficial occlusion properties of the oil compo- 111 nent [27]. 112 An increased solubilization in NLC may also improve skin depo- 113 sition as for tacrolimus [28], celecoxib [29], and psoralen [30] since 114 dissolved compounds build up a higher concentration gradient 115 enabling an improved penetration and/or permeation.…”