Polymeric nanogel formulations of nucleoside analogs

Vinogradov, Serguei V.

doi:10.1517/17425247.4.1.5

Cited by 73 publications

(57 citation statements)

References 71 publications

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“…Nanogels can contain and protect drugs (and nucleotide therapeutics) and regulate their release by incorporating high-affinity functional groups, stimuli-responsive conformations and biodegradable bonds into the polymeric network (Vinogradov, 2007;Kabanov & Vinogradov, 2009;Sasaki & Akiyoshi, 2010;Chacko et al, 2012;Moya-Ortega et al, 2012). Similar to other nanoparticulate DDS, nanogels can easily be administered in liquid form for parenteral drug delivery.…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

“…The nanoscale size of nanogels gives them a high specific surface area that is available for further bioconjugation of active targeting agents and macromolecules. Drug release properties, biodistribution and excretion can be modulated through size adjustments, too (Vinogradov, 2007;Kabanov & Vinogradov, 2009;Sasaki & Akiyoshi, 2010;Chacko et al, 2012;Moya-Ortega et al, 2012).…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

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Advanced drug delivery nanosystems (aDDnSs): a mini-review

Demetzos¹,

Pippa²

2013

Drug Delivery

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Significant progress has been made in nanoscale drugs and delivery systems employing diverse chemical formulations to facilitate the rate of drug delivery and to improve its pharmacokinetics. Biocompatible nanomaterials have been used as biological markers, contrast agents for imaging, healthcare products, pharmaceuticals, drug-delivery systems as well as in detection, diagnosis and treatment of various types of diseases. The classification of drug delivery nanosystems (DDnSs) is a crucial issue and fundamental efforts on this subject are missing from the literature. This article deals with the classification of DDnSs with a modulatory controlled release profile (MCR) denoted as modulatory controlled release nanosystems (MCRnSs). Conventional (c) and advanced (a) DDnSs are denoted by the acronyms cDDnSs and aDDnSs, and can be composed of a single or more than one biomaterials, respectively. The classification was based on their characteristics such as: surface functionality (f), the nature of biomaterials used and the kind of interactions between biomaterials. The aDDnSs can be classified as hybridic (Hy-) or chimeric (Chi-) based on the nature -same or different respectively -of biomaterials and inorganic materials used. The nature of the elements used for producing advanced biomaterials is of great importance and medicinal chemistry contributes effectively to the production of aDDnSs.

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Section: Drug Delivery Systemsmentioning

confidence: 99%

Section: Drug Delivery Systemsmentioning

confidence: 99%

Advanced drug delivery nanosystems (aDDnSs): a mini-review

Demetzos¹,

Pippa²

2013

Drug Delivery

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“…Based on this assumption we selected the nanoparticles ranging in size between 100 and 200 nm for loading with curcumin. Curcumin was encapsulated into polymeric-based carrier, the colloidal nanogels, a recently developed by Dr. Vinogradov and his colleagues a new family of carriers for encapsulation and delivery of drugs and biomacromolecules (31)(32)(33)(34)(35)(36)(37)(38). Colloidal microgels have recently received attention as environmentally responsive systems and now are increasingly used in applications as carriers for therapeutic drugs and diagnostic agents.…”

Section: Nanogelsmentioning

confidence: 99%

“…In the synthesis we used a biodegradable version of the polycation (SPss) consisted of spermine molecules interconnected by disulfide bridges cleavable in the reducing intracellular environment. The SPss was obtained by cross-linking of spermine molecules with an equimolar amount of dimethyl 3,3'-dithiobispropyonimidate.2HCl (DTBP) (33). An average Mw of the synthesized SPss was equal to ca.…”

Section: Nanogel Synthesismentioning

confidence: 99%

Curcumin-Combretastatin Nanocells as Breast Cancer Cytotoxic and Antiangiogenic Agent

Reeves¹,

Wickstrom²,

Vinogradov³

2008

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information ABSTRACTThe focus of our concept was to develop a novel therapeutical nanodevice aiming to deliver the anticancer natural compound curcumin specifically to breast cancer cells. We have successfully fabricated two kinds of nanocarriers, the single-walled carbon nanotubes (SWCNT) and the colloidal nanogels, and loaded them with curcumin. We have demonstrated that while the nanocarriers themselves are non-toxic to the breast cancer cells, the loaded nanoconstructs are significantly more cytotoxic than curcumin alone, in particular, in nanogel formulation. Our future research will focus on targeting the curcumin-loaded nanoconstructs with the antibodies against breast cancer cells surface receptors. The key challenges in cancer therapy are the delivery of the anticancer drugs directly to the cancer cells and the drug's side effects. Thus, it's imperative to identify new anticancer agents that are non-toxic and highly effective to induce cell death, while preventing damage to the normal cells. Nanotechnology, the intersection of materials science and chemistry, is allowing advances that were never before possible in delivering therapeutic agents at desired rates exactly where needed in the body. These drug-loaded nanovehicles are capable of circumventing the systemic toxicity and adverse effects associated with conventional chemotherapy. The research brings doctors one step closer to being able to inject patients with nanoparticles that bore inside tumors and release powerful doses of cancer-killing drugs while leaving the rest of the body unscathed. Our proposal centers on one of the natural compounds, the potent anticancer agent curcumin that specifically kills cancer cells, while being non-toxic to the normal cells. Curcumin (diferuloylmethane) is one of the most well known naturally occurring compounds, a polyphenol derived from the plant Curcuma longa, commonly called turmeric. Turmeric holds a high place in Ayurvedic medicine as a "cleanser of the body" with anti-oxidant, antiinflammatory and anti-carcinogenic properties. People whose diets are rich in turmeric have lower rates of breast cancer as well as prostate, lung and colon cancers (1, 2). Recent research at the M.D. Anderson Cancer Center in Houston suggests that curcumin may help prevent the spread of a breast cancer (3, 4). The anticancer potential of curcumin stems from its ability to suppress proliferation of a wide variety of tumor cells, modulate transcription factors (e.g. NF-kappa B, AP-1 and Egr-1), down-regulate the expression o...

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“…This symposium focused on recent advances in nanomedicine, especially nanosystems for diagnosis and therapy of human diseases. The 2006 symposium continued a series of meetings initiated as a joint US/Japan Mini-Symposium in 2003 in Omaha, Nebraska and followed by the second symposium in 2004 in Brooklyn, New York [2,3] and the third symposium in 2005 in Baltimore, Maryland [4]. The fourth symposium attracted nearly 180 scientists from 16 countries, 24 leading experts as guest speakers and several dozen poster presenters.…”

mentioning

confidence: 99%

Fourth International Nanomedicine and Drug Delivery Symposium (NanoDDS'06)

Kabanov¹

2007

Journal of Controlled Release

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This issue presents some important topics that were covered during the 2006 symposium. Particular attention is in design and evaluation of novel nanomaterials for drug and gene delivery. One of the articles discusses fabrication of polymeric nanoparticles by innovative lithographic technique. Another article provides an update on formulations of biodegradable nanogel carriers for delivery of nucleoside analogs into a cell. Of significant interest to the readers will be an article discussing particle shape as an important design parameter for microand nanoscale drug delivery carriers. A theme of gene delivery is presented by several publications including development of novel colloidally stable copolymer systems for gene delivery and use of multicellular tumor spheroids for screening non-viral polymeric gene vectors with low cytotoxicity and high transfection efficiencies. Considerable attention is also in development of innovative approaches for analysis of the intracellular behavior of DNA nanoparticles such as fluorescence correlation spectroscopy. All together, we believe that this issue will be of interest to numerous readers of the journal and will nicely supplement two other recent special issues presenting original and review contributions from the previous symposia of this series [3,4].

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Polymeric nanogel formulations of nucleoside analogs

Cited by 73 publications

References 71 publications

Advanced drug delivery nanosystems (aDDnSs): a mini-review

Advanced drug delivery nanosystems (aDDnSs): a mini-review

Curcumin-Combretastatin Nanocells as Breast Cancer Cytotoxic and Antiangiogenic Agent

Fourth International Nanomedicine and Drug Delivery Symposium (NanoDDS'06)

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