Polymeric monolith column composited with multiwalled carbon nanotubes‐β‐cyclodextrin for the selective extraction of psoralen and isopsoralen

Abstract

A polymeric column that contains multiwalled carbon nanotubes-β-cyclodextrin composite was developed. The composite was wrapped into the poly(butyl methacrylate-ethylene dimethacrylate) monolith column (0.76 mm id and 10 cm in length). The column was then applied for the online solid-phase microextraction of psoralen and isopsoralen from Fructus Psoraleae. Following microextraction, the coumarins were quantified by high-performance liquid chromatography with C separation column and UV detection. The effects of sample flow rate, sample volume, and pH value were optimized. The method showed low limits of detection (20 pg/mL, S/N = 3) for both psoralen and isopsoralen. Finally the method was successfully applied to the determination of psoralen and isopsoralen in spiked herb extracts and rat plasma where it gave recoveries that ranged between 93.2 and 102.1%. The empty hydrophobic cavities of β-cyclodextrin and the hydrophobicity of multiwalled carbon nanotubes provided specific extraction capability for psoralen and isopsoralen.

Use of hydroxypropyl β‐cyclodextrin hybrid monolithic material as adsorbent for dispersive solid‐phase extraction of fluoroquinolones from environmental water samples

“…However, the research on CD-based monolithic material in DSPE was rare. All the CD-based monolithic materials in sample treatment were modified with native β-CD and then used as SPME adsorbents to extract only one or two drugs [25][26][27][28]. As mentioned, the procedure of SPME was time-consuming.…”

Simultaneous determination of levofloxacin and ciprofloxacin in human urine by ionic‐liquid‐based, dual‐template molecularly imprinted coated graphene oxide monolithic solid‐phase extraction

“…Hence, the obtained bulk polymerization can be applied only after a tedious and time consuming post‐treatment process of removing the template by soxhlet, crushing, grinding, drying, and further grinding to amorphous particles, which can destroy the binding sites, and reduce the selectivity and chromatographic performance . The development of MIP monoliths is an alternative approach that can overcome the shortcomings of conventional MIP packed columns .…”