Polymeric Mixed Micelles: Improving the Anticancer Efficacy of Single-Copolymer Micelles

Manjappa, Arehalli S.; Kumbhar, Popat; Patil, Ajit B.; Disouza, John; Patravale, Vandana

doi:10.1615/critrevtherdrugcarriersyst.2018020481

Cited by 36 publications

(15 citation statements)

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“…In aqueous environments, these MNMs spontaneously assemble into a core-shell-like structure (Figure 1(Ab)). The hydrophobic segment aggregates integrate in the core, while the hydrophilic segment segregates the shell block [104], showing a high distribution and high hydrophobic cargo-loading capacity into the core [105]. For example, in a strategy recently developed by our group, polymeric nanomicelles based on an amphiphilic poly (lactic acid-co-glycolic acid) (PLGA) polymer were self-assembled.…”

Section: Polymeric Micro/nanomicellesmentioning

confidence: 99%

Polymeric Micro/Nanocarriers and Motors for Cargo Transport and Phototriggered Delivery

Mena-Giraldo

Orozco

2021

Polymers

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Smart polymer-based micro/nanoassemblies have emerged as a promising alternative for transporting and delivering a myriad of cargo. Cargo encapsulation into (or linked to) polymeric micro/nanocarrier (PC) strategies may help to conserve cargo activity and functionality when interacting with its surroundings in its journey to the target. PCs for cargo phototriggering allow for excellent spatiotemporal control via irradiation as an external stimulus, thus regulating the delivery kinetics of cargo and potentially increasing its therapeutic effect. Micromotors based on PCs offer an accelerated cargo–medium interaction for biomedical, environmental, and many other applications. This review collects the recent achievements in PC development based on nanomicelles, nanospheres, and nanopolymersomes, among others, with enhanced properties to increase cargo protection and cargo release efficiency triggered by ultraviolet (UV) and near-infrared (NIR) irradiation, including light-stimulated polymeric micromotors for propulsion, cargo transport, biosensing, and photo-thermal therapy. We emphasize the challenges of positioning PCs as drug delivery systems, as well as the outstanding opportunities of light-stimulated polymeric micromotors for practical applications.

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Section: Polymeric Micro/nanomicellesmentioning

confidence: 99%

Polymeric Micro/Nanocarriers and Motors for Cargo Transport and Phototriggered Delivery

Mena-Giraldo

Orozco

2021

Polymers

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“…Based on this rationale, the MMs have distinctive advantages over conventional individual micelles (prepared from single copolymer) by demonstrating increased aqueous solubility, enhanced stability, prolonged circulation time, improved pharmacokinetic and dynamic properties of drugs. 29 …”

Section: Discussionmentioning

confidence: 99%

Antidiabetic and antihyperlipidemic effects of Argyreia pierreana and Matelea denticulata: Higher activity of the micellar nanoformulation over the crude extract

Gudise

Chowdhury

Manjappa

2021

Journal of Traditional and Complementary Medicine

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Background and aim Herbal medicine combined with nanotechnology is widely proposed to improve the oral bioavailability, reduce the required dose and side effects, and improve the pharmacological efficacy of extracts. Thus, this study evaluated the in vivo antidiabetic and antihyperlipidemic activities of ethanolic leaf extracts of Argyreia pierreana (AP) and Matelea denticulata (MP) plants in comparison with their micellar nanoformulations. Materials and methods The mixed micelles (MMs) loaded with crude extracts (CEs) of AP and MD (AP-MMs and MD-MMs) were prepared using a film dispersion technique. Type 2 diabetes was induced in rats using high-fat diet (HFD) and low-dose (35 mg/kg) streptozotocin (STZ) injection. The pharmacological actions of CEs, AP-MMs and MD-MMs were determined in type 2 diabetic Sprague-Dawley rats. Results Oral treatments with low-dose AP-MMs and MD-MMs having a mean particle size of 163 ± 10 nm and 145 ± 8 nm respectively, resulted in significantly decreased fasting blood glucose level and increased serum insulin, glucokinase levels, and normalized the elevated levels of hemoglobin A1C and glucose-6-phosphatase. Both extracts significantly decreased serum total cholesterol, triglycerides, and low-density lipoprotein, as well as elevated high-density lipoprotein levels. Additionally, improvements in antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase) and malondialdehyde levels were evidenced clearly in tested vital organs (brain, heart, liver). Conclusion This is the first report of the antidiabetic and antihyperlipidemic activities of ethanolic leaf extracts of AP and MP plants. Our findings indicate the potential utility of nanotechnology in improving the oral therapeutic efficacy of herbal extracts.

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“…The PPC micelles showed significantly less CMC. These relatively lower CMC of PPC micelles revealed that they would remain stable in solutions even after in vivo dilution [23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Podophyllotoxin-polyacrylic acid conjugate micelles: improved anticancer efficacy against multidrug-resistant breast cancer

Kumbhar

Sakate

Patil

et al. 2020

J Egypt Natl Canc Inst

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Background Podophyllotoxin (PPT) is a naturally occurring compound obtained from the roots of Podophyllum species, indicated for a variety of malignant tumors such as breast, lung, and liver tumors. This toxic polyphenol (PPT) exhibited significant activity against P-glycoprotein (P-gp) mediated multidrug-resistant (MDR) cancer cells. However, extremely poor water solubility, a narrow therapeutic window, and high toxicity have greatly restricted the clinical uses of PPT. Therefore, the present research was aimed to synthesize the water-soluble ester prodrug of PPT with polyacrylic acid (PAA), a water-soluble polymer by Steglich esterification reaction, and to screen it for assay, solubility, in vitro hemolysis, in vitro release, and in vitro anticancer activity. Results The Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopy results revealed the successful synthesis of podophyllotoxin-polyacrylic acid conjugate (PPC). The assay and saturation solubility of the prodrug is found to be 64.01 ± 4.5% and 1.39 ± 0.05 mg/mL (PPT equivalent) respectively. The PPC showed CMC (critical micelle concentration) of 0.430 mg/mL in distilled water at room temperature. The PPC micelles showed a mean particle size of 215 ± 11 nm with polydispersity index (PDI) of 0.193 ± 0.006. Further, the transmission electron microscope (TEM) results confirmed the self-assembling character of PPC into micelles. The PPC caused significantly less hemolysis (18.6 ± 2.9%) than plain PPT solution. Also, it demonstrated significantly (p < 0.01) higher in vitro cytotoxicity against both sensitive as well as resistance human breast cancer cells (MCF-7 and MDA MB-231) after 48 h of treatment. Conclusion The obtained study results clearly revealed the notable in vitro anticancer activity of PPT following its esterification with PAA. However, further in vivo studies are needed to ascertain its efficacy against a variety of cancers.

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Polymeric Mixed Micelles: Improving the Anticancer Efficacy of Single-Copolymer Micelles

Cited by 36 publications

References 0 publications

Polymeric Micro/Nanocarriers and Motors for Cargo Transport and Phototriggered Delivery

Polymeric Micro/Nanocarriers and Motors for Cargo Transport and Phototriggered Delivery

Antidiabetic and antihyperlipidemic effects of Argyreia pierreana and Matelea denticulata: Higher activity of the micellar nanoformulation over the crude extract

Podophyllotoxin-polyacrylic acid conjugate micelles: improved anticancer efficacy against multidrug-resistant breast cancer

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