Polymeric microneedles for transdermal drug delivery- a review of recent studies

Karim, Ziaul; Karwa, Preeti; Hiremath, Shobha Rani R

doi:10.1016/j.jddst.2022.103760

Cited by 17 publications

(12 citation statements)

References 129 publications

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“…Dissolving polymeric MNs are widely produced using polyvinyl alcohol (PVA) and polyvinyl pyrrolidone (PVP) polymers. In addition, water-soluble polysaccharides such as dextran, hydroxypropyl methylcellulose (HPMC), hydroxypropyl cellulose (HPC), sodium alginate, and hyaluronic acid are suitable polymers [ 111 ]. Than et al developed a drug-loaded eye patch equipped with polymeric double-layered MNs (DL-MN) which were made of crosslinked methacrylated hyaluronic (MeHA) polymer and provided a controlled drug release profile ( Figure 3 A).…”

Section: Combination Use Of Nanotechnology and Other New Techniques F...mentioning

confidence: 99%

“…For instance, pilocarpine-coated stainless steel MNs were administered using intrascleral and intracorneal approaches to increase the absorption rate of pilocarpine in the treatment of glaucoma. MNs were applied to rabbit eye and led to increased bioavailability in the cornea [ 111 , 123 ].…”

Section: Combination Use Of Nanotechnology and Other New Techniques F...mentioning

confidence: 99%

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Application of Convergent Science and Technology toward Ocular Disease Treatment

et al. 2023

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Eyes are one of the main critical organs of the body that provide our brain with the most information about the surrounding environment. Disturbance in the activity of this informational organ, resulting from different ocular diseases, could affect the quality of life, so finding appropriate methods for treating ocular disease has attracted lots of attention. This is especially due to the ineffectiveness of the conventional therapeutic method to deliver drugs into the interior parts of the eye, and the also presence of barriers such as tear film, blood-ocular, and blood-retina barriers. Recently, some novel techniques, such as different types of contact lenses, micro and nanoneedles and in situ gels, have been introduced which can overcome the previously mentioned barriers. These novel techniques could enhance the bioavailability of therapeutic components inside the eyes, deliver them to the posterior side of the eyes, release them in a controlled manner, and reduce the side effects of previous methods (such as eye drops). Accordingly, this review paper aims to summarize some of the evidence on the effectiveness of these new techniques for treating ocular disease, their preclinical and clinical progression, current limitations, and future perspectives.

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Section: Combination Use Of Nanotechnology and Other New Techniques F...mentioning

confidence: 99%

Section: Combination Use Of Nanotechnology and Other New Techniques F...mentioning

confidence: 99%

Application of Convergent Science and Technology toward Ocular Disease Treatment

et al. 2023

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“…Among them, ICG is a non-toxic and a FDA approved fluorescent/imaging agent, reported with high photothermal transduction efficiency both in vitro and in vivo. [35][36][37][38][39][40] With the development of nanotechnology, several modalities can be incorporated within a single nano system, thereby, rendering an enhanced synergistic effect against the microbial species. Recent approach toward management of infectious diseases is by not relying on a single therapeutic strategy but rather by developing a multifunctional nanosystem for a combinational therapy.…”

Section: Introductionmentioning

confidence: 99%

Ethosomal Nanoformulations for Combinational Photothermal Therapy of Fungal Keratitis

Mudigunda

Sankaranarayanan

Veeresh

et al. 2023

Advanced Therapeutics

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Fungal keratitis/mycotic keratitis or keratomycosis, is characterized by the inflammation of underlying stroma of corneal epithelium due to fungal infection. Multi‐drug resistance and subsequent recurrence of infection limits the clinical outcomes of anti‐fungal agents such as Amphotericin B and Natamycin; and therefore, demands research on newer anti‐microbial strategies. In this study, the authors have synthesized and characterized ethosomes (IAEs) encapsulating a NIR dye, Indocyanine green (ICG), and an anti‐fungal drug, Amphotericin B, for a combinational photothermal therapy of fungal keratitis. The in vitro anti‐fungal efficacy of the IAEs is validated against Candida albicans by colony formation assay, calcofluor staining, and SEM analysis. The results indicate that the IAEs, upon NIR irradiation, displays a synergistic anti‐fungal efficacy. The IAEs are highly biocompatible when tested using a human corneal epithelial (HCE) cell line model (in vitro) and a Draize eye test model in rabbits (in vivo). Further, it is observed that the IAEs,upon NIR laser exposure significantly eliminate the fungal infection in rat model of occular fungal keratitis. The research indicates that the IAEs nano‐formulation exhibits a synergistic and sustained anti‐fungal effect paving its way for further translation from bench to bedside for the efficient management of fungal keratitis.

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“…Skin comprises the epidermis, dermis and subcutaneous tissue [ 4 ]. As the outermost layer of skin, the epidermis is generally 100–240 μm [ 3 , 5 ]. Local and systemic drug administration with the skin as the primary organ can be found in the oldest surviving medical records [ 6 ], now known as transdermal drug delivery.…”

Section: Introductionmentioning

confidence: 99%

“…Small molecule drugs are transported to the continuous subcutaneous tissue through the intercellular pathway. The polar/non-polar solute assigned by the appropriate O/W coefficient can diffuse the drug into water and keratinocytes via intracellular pathways [ 5 , 9 , 10 ] but with reduced bioavailability. The most primitive transdermal drug delivery is a patch, in which the required drug is used as a paste, wrapped with bandages or gauze, and then applied to the affected area for local treatment [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Silk Fibroin Microneedles for Transdermal Drug Delivery: Where Do We Stand and How Far Can We Proceed?

Yan

Tan

et al. 2023

Pharmaceutics

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Microneedles are a patient-friendly technique for delivering drugs to the site of action in place of traditional oral and injectable administration. Silk fibroin represents an interesting polymeric biomaterial because of its mechanical properties, thermal stability, biocompatibility and possibility of control via genetic engineering. This review focuses on the critical research progress of silk fibroin microneedles since their inception, analyzes in detail the structure and properties of silk fibroin, the types of silk fibroin microneedles, drug delivery applications and clinical trials, and summarizes the future development trend in this field. It also proposes the future research direction of silk fibroin microneedles, including increasing drug loading doses and enriching drug loading types as well as exploring silk fibroin microneedles with stimulation-responsive drug release functions. The safety and effectiveness of silk fibroin microneedles should be further verified in clinical trials at different stages.

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Polymeric microneedles for transdermal drug delivery- a review of recent studies

Cited by 17 publications

References 129 publications

Application of Convergent Science and Technology toward Ocular Disease Treatment

Application of Convergent Science and Technology toward Ocular Disease Treatment

Ethosomal Nanoformulations for Combinational Photothermal Therapy of Fungal Keratitis

Silk Fibroin Microneedles for Transdermal Drug Delivery: Where Do We Stand and How Far Can We Proceed?

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