Polymeric micelles: précis for past, present and future

Pérez, Sebastián E.; Haidar, Ziyad S.

doi:10.1016/b978-0-323-89868-3.00019-7

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…The most critical point in the preparation of PMs with optimal characteristics is the selection of the right polymers and modifying agents. Many characteristic features of the PMs discussed above are directly dependent on the properties and structure of the polymer/modifying agent [ 13 ].…”

Section: Polymeric Micelles For Nucleic Acid Deliverymentioning

confidence: 99%

“…Polymeric micelles can incorporate and transport the lipophilic agents in the hydrophobic inner core and hydrophilic agents in the hydrophilic outer shell. Compared to micellar structures composed of conventional surfactant molecules, i.e., small molar mass molecules, polymeric micelles are formed at lower CMC values and tend to be more stable in vitro and in vivo [ 12 , 13 ]. For this reason, polymeric micelles are widely used in studies as nanocarrier systems for the delivery of drugs and other therapeutic agents.…”

Section: Introductionmentioning

confidence: 99%

“…Owing to the development of polymerization technology, copolymers with different structures and desired physicochemical properties can be synthesized using various hydrophilic, hydrophobic and cationic blocks [ 8 , 15 ]. Thus, the structural properties of polymeric micelles, such as their surface charge and size and the release mechanism of the therapeutics, can be altered to design effective delivery systems and optimize other factors, such as cellular uptake, endosomal escape and cellular release, that influence treatment efficacy [ 13 ]. Furthermore, polymeric micelles offer the opportunity to delivery both drugs and nucleic acid therapeutics simultaneously.…”

Section: Introductionmentioning

confidence: 99%

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Polymeric-Micelle-Based Delivery Systems for Nucleic Acids

et al. 2023

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Nucleic acids can modulate gene expression specifically. They are increasingly being utilized and show huge potential for the prevention or treatment of various diseases. However, the clinical translation of nucleic acids faces many challenges due to their rapid clearance after administration, low stability in physiological fluids and limited cellular uptake, which is associated with an inability to reach the intracellular target site and poor efficacy. For many years, tremendous efforts have been made to design appropriate delivery systems that enable the safe and effective delivery of nucleic acids at the target site to achieve high therapeutic outcomes. Among the different delivery platforms investigated, polymeric micelles have emerged as suitable delivery vehicles due to the versatility of their structures and the possibility to tailor their composition for overcoming extracellular and intracellular barriers, thus enhancing therapeutic efficacy. Many strategies, such as the addition of stimuli-sensitive groups or specific ligands, can be used to facilitate the delivery of various nucleic acids and improve targeting and accumulation at the site of action while protecting nucleic acids from degradation and promoting their cellular uptake. Furthermore, polymeric micelles can be used to deliver both chemotherapeutic drugs and nucleic acid therapeutics simultaneously to achieve synergistic combination treatment. This review focuses on the design approaches and current developments in polymeric micelles for the delivery of nucleic acids. The different preparation methods and characteristic features of polymeric micelles are covered. The current state of the art of polymeric micelles as carriers for nucleic acids is discussed while highlighting the delivery challenges of nucleic acids and how to overcome them and how to improve the safety and efficacy of nucleic acids after local or systemic administration.

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Section: Polymeric Micelles For Nucleic Acid Deliverymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Polymeric-Micelle-Based Delivery Systems for Nucleic Acids

et al. 2023

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Characterization of the Interaction of Polymeric Micelles with siRNA: A Combined Experimental and Molecular Dynamics Study

et al. 2022

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The simulation of large molecular systems remains a daunting challenge, which justifies the exploration of novel methodologies to keep computers as an ideal companion tool for everyday laboratory work. Whole micelles, bigger than 20 nm in size, formed by the self-assembly of hundreds of copolymers containing more than 50 repeating units, have until now rarely been simulated, due to a lack of computational power. Therefore, a flexible amphiphilic triblock copolymer (mPEG45-α-PLL10-PLA25) containing a total of 80 repeating units, has been emulated and synthesized to embody compactified nanoconstructs of over 900 assembled copolymers, sized between 80 and 100 nm, for siRNA complexing purposes. In this study, the tailored triblock copolymers containing a controlled number of amino groups, were used as a support model to address the binding behavior of STAT3-siRNA, in the formation of micelleplexes. Since increasingly complex drug delivery systems require an ever more optimized physicochemical characterization, a converging description has been implemented by a combination of experimentation and computational simulations. The computational data were advantageous in allowing for the assumption of an optimal N/P ratio favoring both conformational rigidifications of STAT3-siRNA with low competitive phenomena at the binding sites of the micellar carriers. These calculations were consistent with the experimental data showing that an N/P ratio of 1.5 resulted in a sufficient amount of complexed STAT3-siRNA with an electrical potential at the slipping plane of the nanopharmaceuticals, close to the charge neutralization.

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Formation of Polymeric Micelle-Mixed Micelles: The Drug Delivery, and Radiotherapy Applications, Interaction, and Investigation by Laser Light

Ortac,

Mutlu,

Hakan Yilmaz

et al. 2024

Design and Applications of Self-Assembly Aggregates - From Micelles to Nanoemulsions [Working Title]

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Surfactant micelles consist of a hydrophilic head that faces the solvent and a hydrophobic tail that faces the core. Mixed micelles, composed of several block copolymers, enhance medication administration. This text discusses the physical-chemical properties, in vivo and in vitro performance, and unique combinations of single and mixed copolymer micelles. It also investigates multifunctional mixed micelles that may respond to various stimuli for cancer treatment. Polymeric micelle-mixed micelles exhibit potential in the field of cancer radiation therapy. The purpose of encapsulating radiosensitizers in polymeric micelle-mixed micelles is to specifically target cancer cells and minimize harm to the rest of the body. Additionally, we can engineer polymeric micelle-mixed micelles to respond to specific conditions in the tumor microenvironment, like changes in pH or enzyme activity. Imaging compounds can be incorporated into mixed micelles to track the distribution and accumulation of tumor medicine during radiation therapy. To summarize, these adaptable nanocarriers can potentially enhance cancer treatment, specifically radiation therapy. However, further investigation is necessary to optimize the use of polymeric micelle-mixed micelles for irradiation. One technique that can determine the size distribution of particles, including multiple distributions and sizes of polymer micelles, whether single or mixed, is laser light scattering.

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Polymeric micelles: précis for past, present and future

Cited by 3 publications

References 27 publications

Polymeric-Micelle-Based Delivery Systems for Nucleic Acids

Polymeric-Micelle-Based Delivery Systems for Nucleic Acids

Characterization of the Interaction of Polymeric Micelles with siRNA: A Combined Experimental and Molecular Dynamics Study

Formation of Polymeric Micelle-Mixed Micelles: The Drug Delivery, and Radiotherapy Applications, Interaction, and Investigation by Laser Light

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