Polymeric micellar nanocarriers: topical treatment of inflammatory diseases

Kahraman, Emine; Durgun, Meltem Ezgi; Güngör, Sevgi; Özsoy, Yıldız

doi:10.1016/b978-0-323-89868-3.00011-2

Cited by 2 publications

(3 citation statements)

References 150 publications

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“…Today, 90% of the drugs on the market fall into this group. These dosage forms usually target the anterior segment of the eye and may have little effect on a possible disease in the posterior segment [136]. On the other hand, they have very low bioavailability due to ocular barriers.…”

Section: Drug Delivery Systemmentioning

confidence: 99%

Nanofibers in Ocular Drug Targeting and Tissue Engineering: Their Importance, Advantages, Advances, and Future Perspectives

et al. 2023

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Nanofibers are frequently encountered in daily life as a modern material with a wide range of applications. The important advantages of production techniques, such as being easy, cost effective, and industrially applicable are important factors in the preference for nanofibers. Nanofibers, which have a broad scope of use in the field of health, are preferred both in drug delivery systems and tissue engineering. Due to the biocompatible materials used in their construction, they are also frequently preferred in ocular applications. The fact that they have a long drug release time as a drug delivery system and have been used in corneal tissue studies, which have been successfully developed in tissue engineering, stand out as important advantages of nanofibers. This review examines nanofibers, their production techniques and general information, nanofiber-based ocular drug delivery systems, and tissue engineering concepts in detail.

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Section: Drug Delivery Systemmentioning

confidence: 99%

Nanofibers in Ocular Drug Targeting and Tissue Engineering: Their Importance, Advantages, Advances, and Future Perspectives

et al. 2023

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“…Figure 1 Micelles are commonly defined as self-assembled structures of amphiphilic molecules above a specific minimal concentration known as the critical micelle concentration (CMC). While micelles are characterized by a hydrophobic inner core and a hydrophilic outer shell, structures named "reverse micelles" or "inverse micelles'' consisting of a hydrophilic core and a hydrophobic shell can also be formed [11]. Although the term Micelles are commonly defined as self-assembled structures of amphiphilic molecules above a specific minimal concentration known as the critical micelle concentration (CMC).…”

Section: Introductionmentioning

confidence: 99%

“…Although the term Micelles are commonly defined as self-assembled structures of amphiphilic molecules above a specific minimal concentration known as the critical micelle concentration (CMC). While micelles are characterized by a hydrophobic inner core and a hydrophilic outer shell, structures named "reverse micelles" or "inverse micelles" consisting of a hydrophilic core and a hydrophobic shell can also be formed [11]. Although the term "micelle" is widely used in the literature to indicate, in general, the formation of core-shell micellar structures, polymeric micelles, specifically, are nano-sized carrier systems that are formed by the self-assembly of amphiphilic blocks (di-or tri-) or graft polymers above the CMC.…”

Section: Introductionmentioning

confidence: 99%

Polymeric-Micelle-Based Delivery Systems for Nucleic Acids

et al. 2023

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Nucleic acids can modulate gene expression specifically. They are increasingly being utilized and show huge potential for the prevention or treatment of various diseases. However, the clinical translation of nucleic acids faces many challenges due to their rapid clearance after administration, low stability in physiological fluids and limited cellular uptake, which is associated with an inability to reach the intracellular target site and poor efficacy. For many years, tremendous efforts have been made to design appropriate delivery systems that enable the safe and effective delivery of nucleic acids at the target site to achieve high therapeutic outcomes. Among the different delivery platforms investigated, polymeric micelles have emerged as suitable delivery vehicles due to the versatility of their structures and the possibility to tailor their composition for overcoming extracellular and intracellular barriers, thus enhancing therapeutic efficacy. Many strategies, such as the addition of stimuli-sensitive groups or specific ligands, can be used to facilitate the delivery of various nucleic acids and improve targeting and accumulation at the site of action while protecting nucleic acids from degradation and promoting their cellular uptake. Furthermore, polymeric micelles can be used to deliver both chemotherapeutic drugs and nucleic acid therapeutics simultaneously to achieve synergistic combination treatment. This review focuses on the design approaches and current developments in polymeric micelles for the delivery of nucleic acids. The different preparation methods and characteristic features of polymeric micelles are covered. The current state of the art of polymeric micelles as carriers for nucleic acids is discussed while highlighting the delivery challenges of nucleic acids and how to overcome them and how to improve the safety and efficacy of nucleic acids after local or systemic administration.

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Polymeric micellar nanocarriers: topical treatment of inflammatory diseases

Cited by 2 publications

References 150 publications

Nanofibers in Ocular Drug Targeting and Tissue Engineering: Their Importance, Advantages, Advances, and Future Perspectives

Nanofibers in Ocular Drug Targeting and Tissue Engineering: Their Importance, Advantages, Advances, and Future Perspectives

Polymeric-Micelle-Based Delivery Systems for Nucleic Acids

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