Polymeric mesoporous silica nanoparticles as a pH-responsive switch to control doxorubicin intracellular delivery

Abstract

Cancer is a leading cause of death. Mesoporous nanomaterials with stimuli sensitivity have received increasing interest as efficient anti-cancer drug carriers. Here, we report hybrid mesoporous nanoparticles of PEGylated silica-poly [2-(dimethylamino)ethyl acrylate] (PEGylated MSN-g-PDMAEA) that can deliver and release the anti-cancer drug doxorubicin (DOX) to tumor cells in a pH dependent switch on/off status. The reversible pH sensitivity resulted in nanoparticles with enhanced functionality through controllable release of the anticancer drug. Confocal laser scanning microscopy (CLSM) and three dimensional (3D) image capture of the intracellular localization of nanoparticles revealed the fast and efficient drug delivery in the human hepatocellular carcinoma cell line. The results highlight the potential of these pH sensitive silica nanoparticles as a novel system for the delivery and controlled release of hydrophobic anti-cancer drugs in the treatment of solid tumors.

Doxorubicin-chitin-poly(caprolactone) composite nanogel for drug delivery

“…Stimulus responsive nanogels are capable of flattening themselves on the vascular surface and simultaneously anchoring in multiple points, have a better chance of specific retention in the targeted disease site [7]. Several polymeric hydrogel systems have been used for the delivery of doxorubicin to cancer cells [8][9][10][11][12][13][14][15]. The advantage of such formulations are their low toxicity, high stability providing longer circulation and smaller size which attribute them increased cellular permeability for passive targeting of solid tumor tissue site with enhanced permeation and retention effect.…”

A pH-sensitive theranostics system based on doxorubicin conjugated with the comb-shaped polymer coating of quantum dots

“…By measuring the free DOX concentration before and after drug loading, the drug loading effciency and the drug loading content of PGMA-g-EDA-g-PEG-QDs-DOX were calculated according to Ref. [26]. The concentration of DOX was quantified by measuring the absorption intensity at 485 nm by ultraviolet-visible (UV-vis) spectroscopy.…”

Physically cross-linked pH-responsive hydrogels with tunable formulations for controlled drug delivery

“…33 The applications of poly-DMAEMA are also extended to gene delivery systems, 34 Drug release can be triggered by various stimuli, including redox potential, light, temperature or pH. [35][36][37][38][39][40][41][42][43][44][45] pH-responsive hydrogels such as poly(acrylic acid) (PAAc) hydrogels are a class of smart hydrogels and have been shown to have potential use in sitespecific delivery of drugs to the GIT due to their muco-adhesive properties. [46][47][48] These hydrogels are also capable of chelating divalent ions (e.g.…”