Doxorubicin-chitin-poly(caprolactone) composite nanogel for drug delivery

Arunraj, T.R.; Rejinold, N. Sanoj; Kumar, N. Ashwin; Jayakumar, R.

doi:10.1016/j.ijbiomac.2013.08.013

Cited by 45 publications

(17 citation statements)

References 28 publications

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“…A two-step decomposition process could be observed in all the scaffolds. The first decomposition step for PCL occurs between 50 and 300°C (Arunraj et al, 2013) and for PCL/PPy scaffolds between 50 and 350°C (Najar and Majid, 2014; Ramaprasad et al, 2017). The first step of decomposition is attributed to residual water loss.…”

Section: Resultsmentioning

confidence: 99%

3D-Printed PCL/PPy Conductive Scaffolds as Three-Dimensional Porous Nerve Guide Conduits (NGCs) for Peripheral Nerve Injury Repair

Vijayavenkataraman

Kannan

Cao

et al. 2019

Front. Bioeng. Biotechnol.

115

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Conductivity is a desirable property of an ideal nerve guide conduit (NGC) that is being considered for peripheral nerve regeneration. Most of the conductive polymers reported in use for fabrication of tissue engineering scaffolds such as polypyrrole (PPy), polyaniline, polythiophene, and poly(3,4-ethylenedioxythiophene) are non-biodegradable and possess weak mechanical properties to be fabricated into 3D structures. In this study, a biodegradable and conductive block copolymer of PPy and Polycaprolactone (PPy-b-PCL) was used to fabricate 3D porous NGCs using a novel electrohydrodynamic jet 3D printing process which offers superior control over fiber diameter, pore size, porosity, and fiber alignment. PCL/PPy scaffolds with three different concentrations of PPy-b-PCL (0.5, 1, and 2% v/v) were fabricated as a mesh (pore size 125 ± 15 μm) and the effect of incorporation of PPy-b-PCL on mechanical properties, biodegradability, and conductivity of the NGCs were studied. The mechanical properties of the scaffolds decreased with the addition of PPy-b-PCL which aided the ability to fabricate softer scaffolds that are closer to the properties of the native human peripheral nerve. With increasing concentrations of PPy-b-PCL, the scaffolds displayed a marked increase in conductivity (ranging from 0.28 to 1.15 mS/cm depending on concentration of PPy). Human embryonic stem cell-derived neural crest stem cells (hESC-NCSCs) were used to investigate the impact of PPy-b-PCL based conductive scaffolds on the growth and differentiation to peripheral neuronal cells. The hESC-NCSCs were able to attach and differentiate to peripheral neurons on PCL and PCL/PPy scaffolds, in particular the PCL/PPy (1% v/v) scaffolds supported higher growth of neural cells and a stronger maturation of hESC-NCSCs to peripheral neuronal cells. Overall, these results suggest that PPy-based conductive scaffolds have potential clinical value as cell-free or cell-laden NGCs for peripheral neuronal regeneration.

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Section: Resultsmentioning

confidence: 99%

3D-Printed PCL/PPy Conductive Scaffolds as Three-Dimensional Porous Nerve Guide Conduits (NGCs) for Peripheral Nerve Injury Repair

Vijayavenkataraman

Kannan

Cao

et al. 2019

Front. Bioeng. Biotechnol.

115

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“…Although intraperitoneal chemotherapy may improve the treatment outcome, unfortunately many drugs have serious side effects, which limit their further application. With the development of nanotechnology, numerous researches provided useful methods to prepare a promising drug delivery carrier with sustained drug release characteristic . In the study of Wang et al, based on the thermal‐sensitive characteristics of PEG‐PCL‐PEG (PECE) hydrogel, 5‐FU loaded hydrogel system has been successfully proposed for in situ treatment of CRPC .…”

Section: Discussionmentioning

confidence: 99%

Use of 5‐Fluorouracil Loaded Micelles and Cisplatin in Thermosensitive Chitosan Hydrogel as an Efficient Therapy against Colorectal Peritoneal Carcinomatosis

Yun

Wang

et al. 2016

Macromolecular Bioscience

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Colorectal peritoneal carcinomatosis (CRPC) is a common systemic metastasis of intra-abdominal cancers. Intraperitoneal chemotherapy against CRPC is at present the preferred treatment. The aim of this study is to develop a novel hydrogel drug delivery system through the combination of 5-fluorouracil (5-FU) loaded polymeric micelles and cisplatin (DDP) in biodegradable thermosensitive chitosan (CS) hydrogel. The prepared CS hydrogel drug is a free-flowing solution at room temperature and forms a stationary gel at body temperature. Therefore, a CRPC mouse model is established to investigate the antitumor activity of CS hydrogel drug system. The results suggest that intraperitoneal administration of CS hydrogel drug can inhibit tumor growth and metastasis, and prolong survival time compared with other groups, thus improving the chemotherapeutic effect. Ki-67 immunohistochemical analysis reveals that tumors in the CS hydrogel drug group has lower cell proliferation in contrast to other groups (P < 0.001). Furthermore, hematoxylin-eosin staining of liver and lung tissue indicates that the CS hydrogel drug has also a certain inhibitory effect on colorectal cancer metastasis to the liver and lung. Hence, the work highlights the potential clinical applications of the CS hydrogel drug.

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“…Hydrophilic chains are able to aggregate through intermolecular interactions and form a network-like structure [68]. Chitin nanogels have been employed to release anti-cancer drugs (e.g., doxorubicin [69]), anti-fungal drugs (e.g., fluconazole [70]), and proteins (e.g., bovine serum albumine (BSA) [71]) [72].…”

Section: Hydrogels Derived From Chitosanmentioning

confidence: 99%

Hydrogels for Biomedical Applications: Cellulose, Chitosan, and Protein/Peptide Derivatives

Valle¹,

Díaz

Puiggalı́

2017

Gels

175

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Hydrogels based on polysaccharide and protein natural polymers are of great interest in biomedical applications and more specifically for tissue regeneration and drug delivery. Cellulose, chitosan (a chitin derivative), and collagen are probably the most important components since they are the most abundant natural polymers on earth (cellulose and chitin) and in the human body (collagen). Peptides also merit attention because their self-assembling properties mimic the proteins that are present in the extracellular matrix. The present review is mainly focused on explaining the recent advances on hydrogels derived from the indicated polymers or their combinations. Attention has also been paid to the development of hydrogels for innovative biomedical uses. Therefore, smart materials displaying stimuli responsiveness and having shape memory properties are considered. The use of micro-and nanogels for drug delivery applications is also discussed, as well as the high potential of protein-based hydrogels in the production of bioactive matrices with recognition ability (molecular imprinting). Finally, mention is also given to the development of 3D bioprinting technologies.

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Doxorubicin-chitin-poly(caprolactone) composite nanogel for drug delivery

Cited by 45 publications

References 28 publications

3D-Printed PCL/PPy Conductive Scaffolds as Three-Dimensional Porous Nerve Guide Conduits (NGCs) for Peripheral Nerve Injury Repair

3D-Printed PCL/PPy Conductive Scaffolds as Three-Dimensional Porous Nerve Guide Conduits (NGCs) for Peripheral Nerve Injury Repair

Use of 5‐Fluorouracil Loaded Micelles and Cisplatin in Thermosensitive Chitosan Hydrogel as an Efficient Therapy against Colorectal Peritoneal Carcinomatosis

Hydrogels for Biomedical Applications: Cellulose, Chitosan, and Protein/Peptide Derivatives

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