Polymeric hollow microcapsules (PHM) via cellulose nanocrystal stabilized Pickering emulsion polymerization

Zhang, Zhen; Cheng, Maria; Gabriel, Mia San; Neto, Ângela Albuquerque Teixeira; Bernardes, Juliana S.; Berry, Richard M.; Tam, Kam Chiu

doi:10.1016/j.jcis.2019.07.107

Cited by 59 publications

(33 citation statements)

References 51 publications

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“…From Equation (10), we can extract that high oil concentration is desired for obtaining low SDI values. We hypothesised that NCC would act as a Pickering emulsion stabiliser [ 68 ], but this was not the case. In the concentrations we used, the function of NCC exhibits a negative effect on the droplet size distribution.…”

Section: Resultsmentioning

confidence: 99%

The Potential of Macroporous Silica—Nanocrystalline Cellulose Combination for Formulating Dry Emulsion Systems with Improved Flow Properties: A DoE Study

2021

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The objective of this study was to explore the possible use of a new combination of two excipients, i.e., nanocrystalline cellulose (NCC) and macroporous silica (MS), as matrix materials for the compounding of dry emulsion systems and the effects these two excipients have on the characteristics of dry emulsion powders produced by the spray drying process. A previously developed liquid O/W nanoemulsion, comprised of simvastatin, 1-oleoyl-rac-glycerol, Miglyol 812 and Tween 20, was employed. In order to comprehend the effects that these two matrix formers have on the spray drying process and on dry emulsion powder characteristics, alone and in combination, a DoE (Design of Experiment) approach was used. The physicochemical properties of dry emulsion samples were characterised by atomic force microscopy, scanning electron microscopy, mercury intrusion porosimetry, energy-dispersive X-ray spectroscopy and laser diffraction analysis. Additionally, total release and dissolution experiments were performed to assess drug release from multiple formulations. It was found that the macroporous silica matrix drastically improved flow properties of dry emulsion powders; however, it partially trapped the oil—drug mixture inside the pores and hindered complete release. NCC showed its potential to reduce oil entrapment in MS, but because of its rod-shaped particles deposited on the MS surface, powder flowability was deteriorated.

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Section: Resultsmentioning

confidence: 99%

The Potential of Macroporous Silica—Nanocrystalline Cellulose Combination for Formulating Dry Emulsion Systems with Improved Flow Properties: A DoE Study

2021

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“…From this perspective, cellulose nanocrystals (CNCs) constitute an interesting brick material: they are biosourced, biodegradable, with a well-known structure, they offer an easily modifiable surface and possess interesting intrinsic mechanical properties (Young modulus of 150 GPa) 6 . It has been shown that CNCs could be used for the stabilization of Pickering emulsions 7 , and the polymerization of these emulsions was subsequently studied to produce polymer particles [8][9][10][11] . The stabilization and polymerization of CNC-stabilized oil-in-water (O/W) Pickering emulsions have been extensively studied, and both free and controlled radical polymerization 8,[12][13][14][15][16][17][18][19] were considered.…”

Section: Introductionmentioning

confidence: 99%

Green Hydrophilic Capsules from Cellulose Nanocrystal-Stabilized Pickering Emulsion Polymerization: Morphology Control and Spongelike Behavior

et al. 2021

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Pickering inverse emulsions of hydroxyl oligoethylene glycol methacrylate were stabilized in isopropyl myristate, a bio-friendly oil, using surface-modified cellulose nanocrystals (CNCs) as stabilizing particles. The emulsions were further polymerized by whether free or controlled radical polymerization (ATRP) taking advantage of the bromoisobutyrate functions grafted on the CNC surface. Suspension polymerization of the emulsion led to full beads or empty capsules morphologies depending on the initiation locus. Thickness of the CNC shell surrounding the polymerized emulsions could be tuned by modulating the aggregation state of the CNCs after their surface modification. An increase from 6 to 40 CNC layers helped improve the compression moduli of the beads from a dozen to hundreds of kPa.

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“…Zhang et al. [ 149 ] prepared polymeric hollow microcapsules (PHMs) from an O/W emulsion of styrene, toluene, and divinylbenzene (DVB). The emulsion was stabilized by unmodified CNCs with 5 mg mL −1 NaCl.…”

Section: Heterogenous Polymerization With Polysaccharide‐based Pickering Emulsifiersmentioning

confidence: 99%

Polysaccharide‐Based Nanoparticles as Pickering Emulsifiers in Emulsion Formulations and Heterogenous Polymerization Systems

Rigg

Champagne

Cunningham

2021

Macromol. Rapid Commun.

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Bio‐based Pickering emulsifiers are a nontoxic alternative to surfactants in emulsion formulations and heterogenous polymerizations. Recent demand for biocompatible and sustainable formulations has accelerated academic interest in polysaccharide‐based nanoparticles as Pickering emulsifiers. Despite the environmental advantages, the inherent hydrophilicity of polysaccharides and their nanoparticles limits efficiency and application range. Modification of the polysaccharide surface is often required in the development of ultrastable, functional, and water‐in‐oil (W/O) systems. Complex surface modification calls into question the sustainability of polysaccharide‐based nanoparticles and is identified as a significant barrier to commercialization. This review summarizes the use of nanocelluloses, ‐starches, and ‐chitins as Pickering emulsifiers, highlights trends and best practices in surface modification, and provides recommendations to expedite commercialization.

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Polymeric hollow microcapsules (PHM) via cellulose nanocrystal stabilized Pickering emulsion polymerization

Cited by 59 publications

References 51 publications

The Potential of Macroporous Silica—Nanocrystalline Cellulose Combination for Formulating Dry Emulsion Systems with Improved Flow Properties: A DoE Study

The Potential of Macroporous Silica—Nanocrystalline Cellulose Combination for Formulating Dry Emulsion Systems with Improved Flow Properties: A DoE Study

Green Hydrophilic Capsules from Cellulose Nanocrystal-Stabilized Pickering Emulsion Polymerization: Morphology Control and Spongelike Behavior

Polysaccharide‐Based Nanoparticles as Pickering Emulsifiers in Emulsion Formulations and Heterogenous Polymerization Systems

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