Polymeric dual-modal imaging nanoprobe with two-photon aggregation-induced emission for fluorescence imaging and gadolinium-chelation for magnetic resonance imaging

Xiao, Xu; Cai, Hao; Huang, Qiaorong; Wang, Bing; Wang, Xiaoming; Luo, Qiang; Li, Yinggang; Zhang, Hu; Gong, Qiyong; Ma, Xuelei; Gu, Zhongwei; Luo, Qiang

doi:10.1016/j.bioactmat.2022.04.026

Cited by 46 publications

(30 citation statements)

References 38 publications

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“…Magnetic resonance (MR) imaging is one of the most powerful noninvasive medical imaging techniques with good spatial resolution and high sensitivity, offering superior 3D details and topographic information on soft-tissue contrast ( Chan and Wong, 2007 ; Taboada et al, 2007 ; Xiao et al, 2023 ). To increase the signal-to-noise ratio of information acquired from normal tissues and tumors, it is necessary to use contrast agents ( Aime et al, 2009 ).…”

Section: Introductionmentioning

confidence: 99%

The r1 relaxivity and T1 imaging properties of dendrimer-based manganese and gadolinium chelators in magnetic resonance imaging

Liu

Xia

2022

Front. Bioeng. Biotechnol.

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We report the preparation and characterization of gadolinium (Gd)- or manganese (Mn)-loaded dendrimers and Gd-loaded dendrimer-entrapped gold nanoparticles (Gd-Au DENPs) to examine the relationship between the number of metal ion chelators and r1 relaxivity. In this study, amine-terminated fifth-generation poly(amidoamine) dendrimers (G5.NH2) modified with different numbers of DOTA-NHS chelators were used to chelate Gd and Mn ions. The remaining amine groups were then acetylated completely, followed by the use of materials with better r1 relaxivities and T1-weighted imaging performances as templates to synthesize Gd-Au DENPs. The Gd and Mn chelators as well as Gd-Au DENPs were characterized via different techniques. We show that the r1 relaxivity and T1 imaging performance increase with loading of greater numbers of Gd and Mn ions on the G5.NH2 and that the acetylation process affects the relaxivity and imaging properties to a certain extent. After entrapment with Au NPs, the r1 relaxivity and T1-weighted imaging performance of Gd-Au DENPs decrease with greater loading of Au NPs. This systematic study of the relaxivities and T1-weighted imaging performances of Gd, Mn, and Gd-Au DENP chelators are expected to be a theoretical basis for developing multifunctional dual-mode contrast agents.

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Section: Introductionmentioning

confidence: 99%

The r1 relaxivity and T1 imaging properties of dendrimer-based manganese and gadolinium chelators in magnetic resonance imaging

Liu

Xia

2022

Front. Bioeng. Biotechnol.

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“…The FT-IR and 1 H NMR spectra of the freeze-dried KGM hydrogel were obtained by Fourier-transform infrared spectrometry and nuclear magnetic resonance spectrometry (Bruker 400 MHz), respectively. 36 The hardness, springiness, cohesiveness, and resilience of the hydrogels were measured on a texture analyzer using a flat-bottomed column probe (P/35) with a diameter of 35 mm; the testing parameters were as follows: mode, PA; pretest rate, 1 mm s −1 ; test rate, 1 mm s −1 ; post-measured rate, 1 mm s −1 ; compression, 50%; stop interval, 5 s; data set rate, 200 pps; and trigger value, 5 g. Some key definitions are as follows: the hardness is the first compression when the sample achieves the set deformation and the pressure, which indicates the strength characteristics of the gel structure system under pressure; the springiness is the degree of recovery of the sample after the first compression, depending on the gel state of the entire system; the cohesiveness is the relative resistance of the sample to the second compression after the first compression deformation, reflecting the difficulty of destroying the internal forces of the sample; the resilience is the ability of the sample to bounce back during the first compression. For the scanning electron microscopy (SEM) study, the lyophilized KGM hydrogel was cut into small pieces and treated by gold spraying for observation.…”

Section: Methodsmentioning

confidence: 99%

Konjac glucomannan hydrogel dressing and its combination with Chinese medicine for the wound treatment

Zhao

Guo

et al. 2022

New J. Chem.

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“…Besides physical encapsulation, AIE-active small molecules are chemically conjugated to the amphiphilic copolymers and self-assembled into nanoprobe. Xiao et al synthesized amphiphilic block copolymer covalently conjugated with a two-photon AIE probe (TPBP) and magnetic resonance contrast agent Gd-DOTA ( Figure 3 B) [ 44 ]. In aqueous condition, this copolymer formed self-assembled nanoparticles of about 20 nm, which can be circulated in blood for a long time.…”

Section: Polymeric Nanoplatforms For Two-photon-assisted Imagingmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Recent Advances in Biomedical Applications of Polymeric Nanoplatform Assisted with Two-Photon Absorption Process

et al. 2022

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Polymers are well-recognized carriers useful for delivering therapeutic drug and imaging probes to the target specified in the defined pathophysiological site. The functional drug molecules and imaging agents were chemically attached or physically loaded in the carrier polymer matrix via cleavable spacers. Using appropriate targeting moieties, these polymeric carriers (PCs) loaded with functional molecules were designed to realize target-specific delivery at the cellular level. The biodistribution of these carriers can be tracked using imaging agents with suitable imaging techniques. The drug molecules can be released by cleaving the spacers either by endogenous stimuli (e.g., pH, redox species, glucose level and enzymes) at the targeted physiological site or exogenous stimuli (e.g., light, electrical pulses, ultrasound and magnetism). Recently, two-photon absorption (2PA)-mediated drug delivery and imaging has gained significant attention because TPA from near-infrared light (700–950 nm, NIR) renders light energy similar to the one-photon absorption from ultraviolet (UV) light. NIR has been considered biologically safe unlike UV, which is harmful to soft tissues, cells and blood vessels. In addition to the heat and reactive oxygen species generating capability of 2PA molecules, 2PA-functionalized PCs were also found to be useful for treating diseases such as cancer by photothermal and photodynamic therapies. Herein, insights attained towards the design, synthesis and biomedical applications of 2PA-activated PCs are reviewed. In particular, specific focus is provided to the imaging and drug delivery applications with a special emphasis on multi-responsive platforms.

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Polymeric dual-modal imaging nanoprobe with two-photon aggregation-induced emission for fluorescence imaging and gadolinium-chelation for magnetic resonance imaging

Cited by 46 publications

References 38 publications

The r1 relaxivity and T1 imaging properties of dendrimer-based manganese and gadolinium chelators in magnetic resonance imaging

The r1 relaxivity and T1 imaging properties of dendrimer-based manganese and gadolinium chelators in magnetic resonance imaging

Konjac glucomannan hydrogel dressing and its combination with Chinese medicine for the wound treatment

Recent Advances in Biomedical Applications of Polymeric Nanoplatform Assisted with Two-Photon Absorption Process

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