Konjac glucomannan hydrogel dressing and its combination with Chinese medicine for the wound treatment

Li, Yang; Zhao, Quan; Guo, Zhaoyuan; Liu, Yilin; Gao, Wenxia; Pu, Yuji; He, Bin

doi:10.1039/d2nj04178b

Cited by 5 publications

(2 citation statements)

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“…Glucose/mannose (G/M) is a natural polysaccharide made up of β-1,4-linked D-mannose and D-glucose. G/M possesses ideal properties for a wound dressing such as good biocompatibility, excellent film formation, unique water absorption, and retention properties [28,38]. Native G/M consists of a low degree of approximately 5-10% of acetyl groups, positioned randomly at C-6 of the sugar units [39].…”

Section: Discussionmentioning

confidence: 99%

Wound Healing Performance in a Moist Environment of Crystalline Glucose/Mannose Film as a New Dressing Material Using a Rat Model: Comparing with Medical-Grade Wound Dressing and Alginate

Wong,

Tomura,

Yamamoto

2023

Pharmaceuticals

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Although medical wound dressings produced using hydrocolloids and alginate were effective in wound healing, adhesion at the wound site and the resulting delayed healing have been a problem. As a new wound dressing material, crystalline wound dressings produced from glucose/mannose were used in this study, which aimed to clarify the properties, adhesion reduction, and wound healing performance of a new wound dressing. Crystalline glucose/mannose films were obtained via alkali treatment using the solution casting method. The structure of the crystalline glucose/mannose films was analogous to the cellulose II polymorph, and the crystallinity decreased with time in hydrated conditions. The crystalline glucose/mannose films had adequate water absorption of 34 × 10−4 g/mm3 for 5 min. These allowed crystalline glucose/mannose films to remove excess wound exudates while maintaining a moist wound healing condition. This in vivo study demonstrated the healing effects of three groups, which were crystalline glucose/mannose group > alginate group > hydrocolloid group. At 1 week, the crystalline glucose/mannose group was also found to be non-adhesive to the portion of wound healing. This was evidenced by the earlier onset of the healing process, which assisted in re-epithelization and promotion of collagen formation and maturation. These results implied that crystalline glucose/mannose films were a promising candidate that could accelerate the wound healing process, compared with medical-grade wound dressing and alginate.

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Section: Discussionmentioning

confidence: 99%

Wound Healing Performance in a Moist Environment of Crystalline Glucose/Mannose Film as a New Dressing Material Using a Rat Model: Comparing with Medical-Grade Wound Dressing and Alginate

Wong,

Tomura,

Yamamoto

2023

Pharmaceuticals

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“…Ideal wound repair materials should have good biocompatibility for the biomedical field. 20 To explore the effect of SHK on cell viability, NIH3T3 cells were used to assess the cytocompatibility of SHK/PVA hydrogel. As can be seen in Fig.…”

Section: Cytocompatibility Evaluationmentioning

confidence: 99%

Shikonin delivery strategy through alkali-crosslinked polyvinyl alcohol hydrogel promotes effective wound healing

Wang,

Zheng,

Guo

et al. 2024

New J. Chem.

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Zinc-induced photocrosslinked konjac glucomannan/glycyrrhizic acid hydrogel promotes skin wound healing in diabetic mice through immune regulation

Li,

Wu,

et al. 2025

Carbohydrate Polymers

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Konjac glucomannan hydrogel dressing and its combination with Chinese medicine for the wound treatment

Abstract: Wound dressing with good biocompatibility and bioactivity is urgently needed in wound treatment. Herein, we present a biocompatible hydrogel based on a natural polymer, konjac glucomannan (KGM), and explore its...

Cited by 5 publications

References 54 publications

Wound Healing Performance in a Moist Environment of Crystalline Glucose/Mannose Film as a New Dressing Material Using a Rat Model: Comparing with Medical-Grade Wound Dressing and Alginate

Wound Healing Performance in a Moist Environment of Crystalline Glucose/Mannose Film as a New Dressing Material Using a Rat Model: Comparing with Medical-Grade Wound Dressing and Alginate

Shikonin delivery strategy through alkali-crosslinked polyvinyl alcohol hydrogel promotes effective wound healing

Zinc-induced photocrosslinked konjac glucomannan/glycyrrhizic acid hydrogel promotes skin wound healing in diabetic mice through immune regulation

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