Polymeric coating of fluidizing nano-curcumin via anti-solvent supercritical method for sustained release

Zabihi, Fatemeh; Xin, Na; Li, Sining; Jia, Jinping; Cheng, Tao; Zhao, Yaping

doi:10.1016/j.supflu.2014.02.021

Cited by 36 publications

(26 citation statements)

References 25 publications

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“…This behavior could be caused by the fact that the deposited amount of polymer does not increase with the solution flow because the polymer-particle mass ratio is kept constant [25]. A different behavior for the yield is observed in the work of F. Zabihi et al [15], where the yield increases with the solution flow. Besides, the highest yield value achieved is smaller (50%) than the presented in this work (92%).…”

Section: Solution Flow Ratementioning

confidence: 93%

“…When the solution enters in the super critical phase through a nozzle, the solvent is dissolved in the SCF, which acts as anti-solvent, reaching the super-saturation and causing the precipitation of the solute as fine particles. The only example so far exists consist on a curcumin nanoparticles coated by PLGA using a novel fluidization assisted supercritical anti-solvent procedure [15]. Furthermore, in this work, supercritical anti-solvent is assisted with ultrasonic vibration to improve mixing effects.…”

Section: Introductionmentioning

confidence: 99%

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Titanium dioxide nanoparticle coating in fluidized bed via supercritical anti-solvent process (SAS)

Martín

Romero-Díez

Rodríguez‐Rojo

et al. 2015

Chemical Engineering Journal

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A process to coat nanoparticle agglomerates has been developed and its critical operation parameters have been studied in this work. It consists on a fluidized bed where a supercritical anti-solvent process (SAS) takes place. Titanium dioxide (TiO2), used as model nanoparticle, has been coated with a polymer, Pluronic F-127, from an ethanolic solution. As main factors that can affect the coating process, the following process parameters were studied: the ratio between the velocity of carbon dioxide through the bed and the minimum fluidization velocity (umf), with values from 1.5 to 2.5 times the umf; the density of carbon dioxide, varying from 640 kg/m 3 to 735 kg/m 3 approximately; the flow rate of solution, within an interval between 0.5-2 mL/min; the concentration of the solution, from 0.030 mg/mL to 0.090 mg/mL and the mass ratio polymer-particle, 0.45-1.8 g/g. The process parameters were selected taking into account the values that increased the yield, defined as gram of coating material per gram of introduced polymer amount, and maintained a unimodal particle size distribution (PSD), with low increment in the mean particle size with respect to raw TiO2. All the samples were analyzed by four different methods, which showed the successful results of the experiments. The yield was analyzed gravimetrically, and the PSD was determined by laser diffraction. The presence of polymer on the surface of the nanoparticle agglomerates was verified by FT-IR spectrum and fluorescence microscopy, which also showed the quality and uniformity of the coating. Furthermore, the bulk density of the samples was measured showing a lineal variation with the mass ratio polymer-particle.3

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Section: Solution Flow Ratementioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Titanium dioxide nanoparticle coating in fluidized bed via supercritical anti-solvent process (SAS)

Martín

Romero-Díez

Rodríguez‐Rojo

et al. 2015

Chemical Engineering Journal

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“…Nanocurcumin plays dual roles of fluidized particles and heterogeneous nucleation core. Agglomeration is prevented due to constant dispersion and high potential clash among particles supplied by ultrasonic power, by which high possible loading is achieved [68]. Nanocurcumin appears to be an effective free radical quencher with antioxidant activities and has the potential to inhibit oxidative stress.…”

Section: Removal Of Lead Toxicity By Nanocurcuminmentioning

confidence: 99%

“…Coating of nanocurcumin by polymer will shield if opposed to degradation by light and warmth. Additionally, drug release rate will be restrained by coating polymer [68]. Some studies showed that curcumin bioavailability can be significantly ameliorated by the nanoparticle formulation, with a much higher plasma concentration.…”

Section: Removal Of Lead Toxicity By Nanocurcuminmentioning

confidence: 99%

Lead Exposure in Different Organs of Mammals and Prevention by Curcumin–Nanocurcumin: a Review

Pal

Sachdeva

Gupta

et al. 2015

Biol Trace Elem Res

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Chronic lead exposure is related to many health diseases in mammals. Exposure to lead forms reactive oxygen species reducing body antioxidant enzymes inflicting injury to numerous macromolecules or cell necrosis. Recent studies have revealed oxidative stress as the vital mechanism for lead toxicity. Lead is found to be toxic to several organ systems such as hematopoietic, skeletal, renal, cardiac, hepatic, and reproductive systems and extremely toxic to the central nervous system (CNS). Curcumin, an active ingredient of the dietary spice, and nanocurcumin, a nanoform of curcumin, are found to decrease toxicity due to lead in various organ systems in mouse models. Higher bioavailability, chelating property, and retention time of nanocurcumin over bulk curcumin may pave the way to expand the utility of nanocurcumin to remove lead toxicity from various organ systems within humans.

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“…Zabihi et al [133] successfully encapsulated nano-curcumin in poly(lactic-coglycolic acid) through SAS-EM process, where poly(lactic-co-glycolic acid) solution was sprayed into scCO2 media, in which nano-curcumin particles were fluidized by ultrasonic vibration. The size and yielding of products decreased with increasing Fs.…”

Section: Tailoring Particle Microstructures Via Scf Co-precipitation/mentioning

confidence: 99%

Tailoring Particle Microstructures via Supercritical CO<sub>2</sub> Processes for Particular Drug Delivery

Liu¹,

Jiang

Wang³

2015

CPD

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Strategies for a particular drug delivery are always of great interest for the pharmaceutical industry, and efficient methods of preparing products with controlled particle microstructures are fundamental for the development and application of drug delivery. Supercritical fluid particle design (SCF PD) processes, as a green and effective alternative to traditional methods, have been effectively employed to produce particles with designated microstructures.Combining with research experiences in our research group, this review aims to provide a theoretical framework of SCF PD for particular drug delivery. For any drug delivery formulations, macroscopic properties are directly influenced by the particle microstructures, "Inverse" strategies are introduced at first to obtain the needed particle microstructures for a particular drug delivery in this paper. Then, how to produce particles with designated microstructures via SCF PD processes is discussed, mainly focus on the screening and selection of operating parameters according to thermodynamics and fluid dynamics study. Recent examples of SCF micronization and co-precipitation/ encapsulation processes are also summarized with an emphasis on how to tailor the particle microstructures by controlling the operating parameters.Finally, challenges and issues needed further study are briefly suggested for SCD PD.

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Polymeric coating of fluidizing nano-curcumin via anti-solvent supercritical method for sustained release

Cited by 36 publications

References 25 publications

Titanium dioxide nanoparticle coating in fluidized bed via supercritical anti-solvent process (SAS)

Titanium dioxide nanoparticle coating in fluidized bed via supercritical anti-solvent process (SAS)

Lead Exposure in Different Organs of Mammals and Prevention by Curcumin–Nanocurcumin: a Review

Tailoring Particle Microstructures via Supercritical CO<sub>2</sub> Processes for Particular Drug Delivery

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