Polymeric Binders Suppress Gliadin-Induced Toxicity in the Intestinal Epithelium

Pinier, Maud; Verdú, Elena F.; Nasser‐Eddine, Mohamad; David, Chella S.; Vézina, Anne; Rivard, Nathalie; Leroux, Jean‐Christophe

doi:10.1053/j.gastro.2008.09.016

Cited by 126 publications

(98 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…on animal models observed these effects only in genetically susceptible subjects. 31,32 In our study, the DQ2 or DQ8 human leukocyte antigen (HLA) haplotypes was present only in 22/ 40 (55%) of FH subjects, and it is noteworthy that most patients were suffering from both wheat-and cow's milk-protein hypersensitivity. Consequently, other non-DQ2/DQ8 related mechanisms should be investigated.…”

Section: Discussionmentioning

confidence: 62%

Fecal Assays Detect Hypersensitivity to Cow's Milk Protein and Gluten in Adults With Irritable Bowel Syndrome

Carroccio

Brusca

Mansueto

et al. 2011

Clinical Gastroenterology and Hepatology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 62%

Fecal Assays Detect Hypersensitivity to Cow's Milk Protein and Gluten in Adults With Irritable Bowel Syndrome

Carroccio

Brusca

Mansueto

et al. 2011

Clinical Gastroenterology and Hepatology

View full text Add to dashboard Cite

“…Poly(hydroxyethyl methacrylate-co-styrene sulfonate) (P(HEMA-co-SS), BL-7010, BioLineRx) was shown to complex gliadin and decrease the production of immunostimulatory peptides in digestive fluids (37,38). In a mouse model of gluten sensitivity, the polymer diminished the mucosal and systemic response to an oral gluten-challenge.…”

Section: Polymeric Bindersmentioning

confidence: 99%

“…Pharmaceutical scientists face interesting challenges in overcoming shortcomings with potentially negative effects on compliance and therapeutic benefit (in red). (60) in the stomach and the small intestine) (37). The binding of the polymer to important nutrients has been pointed out as a potential drawback of this approach.…”

Section: Polymeric Bindersmentioning

confidence: 99%

Celiac Disease: A Challenging Disease for Pharmaceutical Scientists

2012

View full text Add to dashboard Cite

Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten-containing grains that affects~1% of the white ethnic population. In the last decades, a rise in prevalence of CD has been observed that cannot be fully explained by improved diagnostics. Genetic predisposition greatly influences the susceptibility of individuals towards CD, though environmental factors also play a role. With no pharmacological treatments available, the only option to keep CD in remission is a strict and permanent exclusion of dietary gluten. Such a gluten-free diet is difficult to maintain because of gluten's omnipresence in food (e.g., additive in processed food). The development of adjuvant therapies which would permit the intake of small amounts of gluten would be desirable to improve the quality of life of patients on a glutenfree diet. Such therapies include gluten-degrading enzymes, polymeric binders, desensitizing vaccines, anti-inflammatory drugs, transglutaminase 2 inhibitors, and HLA-DQ2 blockers. However, many of these approaches pose pharmaceutical challenges with respect to drug formulation and stability, or application route and dosing interval. This perspective article discusses how pharmaceutical scientists may deal with these challenges and contribute to the implementation of novel therapeutic options for patients with CD.

show abstract

“…Gluten c ontains many immunogenic peptides, but there may be weak varieties with a natural low number of T-c ell-stimulatory epitopes [111] . Polymeric binders reduc e the deleterious effec ts of gliadin on intestinal epithelium in c ultured c ells and transgenic mic e [112] . These binders have a strong affinity for gliadin, inhibiting cytoskeleton disorganization and ultrastruc tural c hanges in intestinal epithelial c ells.…”

Section: Alternatives To a Gluten Free Dietmentioning

confidence: 99%

Recent advances in celiac disease

Freeman

Chopra²,

Clandinin³

et al. 2011

WJG

View full text Add to dashboard Cite

Celiac disease now affects about one person in a hundred in Europe and North America. In this review, we consider a number of important and exciting recent developments, such as clinical associations, HLA-DQ2 and HLA-DQ8 predispositions, the concept of potential celiac disease, the use of new imaging/endoscopy techniques, and the development of refractory disease. This review will be of use to all internists, pediatricians and gastroenterologists.

show abstract

Polymeric Binders Suppress Gliadin-Induced Toxicity in the Intestinal Epithelium

Cited by 126 publications

References 40 publications

Fecal Assays Detect Hypersensitivity to Cow's Milk Protein and Gluten in Adults With Irritable Bowel Syndrome

Fecal Assays Detect Hypersensitivity to Cow's Milk Protein and Gluten in Adults With Irritable Bowel Syndrome

Celiac Disease: A Challenging Disease for Pharmaceutical Scientists

Recent advances in celiac disease

Contact Info

Product

Resources

About