Polymeric-based drug delivery systems for veterinary use: State of the art

Carvalho, Suzana Gonçalves; Silvestre, Amanda Letícia Polli; Santos, Aline Martins dos; Fonseca-Santos, Bruno; Rodrigues, Winner Duque; Gremião, Maria Palmira Daflon; Chorilli, Marlus; Villanova, Janaína Cecília Oliveira

doi:10.1016/j.ijpharm.2021.120756

Cited by 11 publications

(4 citation statements)

References 143 publications

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“…Polymer nanocarriers made from naturally occurring and biodegradable polymers have attracted much attention, especially in various drug delivery systems, since they offer a promising means by which to enhance the therapeutic values of drugs by improving their bioavailability, solubility and retention time, as well as benefitting patients due to lower cost and reduced toxicity [1][2][3][4][5]. Through great efforts from researchers, various polymer nanocarriers are currently being developed with the aim of improving drug delivery, especially of hydrophobic drugs including liposome, polymeric nanoparticles, selfassembly micelles, polymersomes, polyelectrolyte complexes, polymer-drug conjugates, dendrimers and others [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

One-Pot Synthesis of Amphiphilic Biopolymers from Oxidized Alginate and Self-Assembly as a Carrier for Sustained Release of Hydrophobic Drugs

et al. 2022

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In this paper, we developed an organic solvent-free, eco-friendly, simple and efficient one-pot approach for the preparation of amphiphilic conjugates (Ugi-OSAOcT) by grafting octylamine (OCA) to oxidized sodium alginate (OSA). The optimum reaction parameters that were obtained based on the degree of substitution (DS) of Ugi-OSAOcT were a reaction time of 12 h, a reaction temperature of 25 °C and a molar ratio of 1:2.4:3:3.3 (OSA:OCA:HAc:TOSMIC), respectively. The chemical structure and composition were characterized by Fourier transform infrared spectroscopy (FTIR), 1H nuclear magnetic resonance (1H NMR), X-ray diffraction (XRD), thermogravimetry analyser (TGA), gel permeation chromatography (GPC) and elemental analysis (EA). It was found that the Ugi-OSAOcT conjugates with a CMC value in the range of 0.30–0.085 mg/mL could self-assemble into stable and spherical micelles with a particle size of 135.7 ± 2.4–196.5 ± 3.8 nm and negative surface potentials of −32.8 ± 0.4–−38.2 ± 0.8 mV. Furthermore, ibuprofen (IBU), which served as a model poorly water-soluble drug, was successfully incorporated into the Ugi-OSAOcT micelles by dialysis method. The drug loading capacity (%DL) and encapsulation efficiency (%EE) of the IBU-loaded Ugi-OSAOcT micelles (IBU/Ugi-OSAOcT = 3:10) reached as much as 10.9 ± 0.4–14.6 ± 0.3% and 40.8 ± 1.6–57.2 ± 1.3%, respectively. The in vitro release study demonstrated that the IBU-loaded micelles had a sustained and pH-responsive drug release behavior. In addition, the DS of the hydrophobic segment on an OSA backbone was demonstrated to have an important effect on IBU loading and drug release behavior. Finally, the in vitro cytotoxicity assay demonstrated that the Ugi-OSAOcT conjugates exhibited no significant cytotoxicity against RAW 264.7 cells up to 1000 µg/mL. Therefore, the amphiphilic Ugi-OSAOcT conjugates synthesized by the green method exhibited great potential to load hydrophobic drugs, acting as a promising nanocarrier capable of responding to pH for sustained release of hydrophobic drugs.

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Section: Introductionmentioning

confidence: 99%

One-Pot Synthesis of Amphiphilic Biopolymers from Oxidized Alginate and Self-Assembly as a Carrier for Sustained Release of Hydrophobic Drugs

et al. 2022

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“…Overall, one of the main advantages of using nanocarriers for delivery of drugs in the livestock population is the reduced frequency of drug administration that results in reduced animal stress, lower treatment costs and lower number of visits by a veterinarian. For pets, the use of nanocarriers can contribute to improve the adherence to therapy, generally low as the animals are uncooperative [3]. In fact, of all veterinary applications, pets with cancer have benefited the most from nanocarriers, while farm animals have benefited much less because of the high cost of them.…”

Section: Introductionmentioning

confidence: 99%

Nanocarriers in Veterinary Medicine: A Challenge for Improving Osteosarcoma Conventional Treatments

et al. 2022

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In recent years, several nanocarrier-based drug delivery systems, such as polymeric nanoparticles, solid lipid nanoparticles, metallic nanoparticles, liposomes, and others, have been explored to target and treat a wide variety of diseases. Their employment has brought many benefits, not only to human medicine but also to veterinary medicine, albeit at a slower rate. Soon, the use of nanocarriers could revolutionize the animal health sector, and many veterinary therapies will be more effective as a result. The purpose of this review is to offer an overview of the main applications of nanocarriers in the veterinary field, from supplements for animal health and reproduction to nanovaccines and nanotherapies. Among the major pathologies that can affect animals, special attention is given to canine osteosarcoma (OSA): a comparison with human OSA is provided and the main treatment options are reviewed emphasizing the benefits that nanocarriers could bring in the treatment of this widespread disease.

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“…Conventional dosage forms for immediate local drug release, such as solutions, creams, ointments, gels and adhesives do not signi cantly interfere with the release of therapeutic agents. However, controlled and sustained release systems are products with advanced therapeutic performance, modulating the release and controlling the time and place in which the drugs are released (Carvalho et al, 2021). Thus, reservoir or matrix systems, where drugs are dispersed, contained in a nucleus, or xed to the surface, have aroused interest (Carvalho et al, 2021(Carvalho et al, , 2020 .…”

Section: Introductionmentioning

confidence: 99%

“…, the SBC, produced in the different culture media presented dissimilar RIF release capacity. These results demonstrated that SBC produced, respectively, in FRU, Z and MS1were capable to maintained greater release concentration when compared with SBC produced in HS and Y media.Drug release from different types of systems can occur by distinct mechanisms such as drug dissolution combined with diffusion through pores or membranes, polymer degradation and/or erosion and osmotic pumping(Carvalho et al, 2021;Fredenberg et al, 2011). Such mechanisms, in turn, can be controlled by gradient drug concentration, penetration of the dissolution drug into the system, or ionic strength swelling rates, among others(Kamaly et al, 2015).…”

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confidence: 99%

Production of sphere-like bacterial cellulose in cultivation media with different carbon sources: a promising sustained release system of rifampicin

Lazarini

Yamada

Nóbrega

et al. 2022

Preprint

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Bacterial cellulose (BC) production can be performed using a static or agitated culture method. In the static culture method, the BC is obtained presents three-dimensional thinner network structures and excellent mechanical properties. In the agitated culture method, BC is produced in the form of granules or fibrous threads with a lower degree of polymerization, mechanical strength, and crystallinity than those formed in static fermentation. Compared with BC membranes, sphere-like BC (SBC) cultured under agitated conditions showed advantages for adsorption due to its larger surface area. The objectives of this work were to obtain SBC, by the bacterial strain Komagataeibacter hansenii ATCC 23769, in agitated cultivation, using media containing different carbon sources carbon sources, such as fructose (FRU), glucose and sucrose (MS1), sucrose (Y) and glucose (Z and HS), aiming to produce supports for sustained release of rifampicin (RIF). SBC has been produced under agitation at 130 rpm and 25°C. SBC obtained were processed to remove bacteria and residues from the culture media and lyophilized. The SBC characterizations were performed by Fourier transform infrared spectroscopy, X-ray diffraction, Field emission gun-scanning electron microscopy, thermogravimetric, and by derivative thermogravimetry analysis. The SBC produced were impregnated with antibiotic RIF and tested for the sustained release capacity of this drug by diffusion method and Frans cell kinetics. SBC that the best results for all tests were produced in FRU, Z and MS1 media, respectively. The results demonstrate the potential of the SBC to contribute to the design of new drug delivery systems with biomedical applications.

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Polymeric-based drug delivery systems for veterinary use: State of the art

Cited by 11 publications

References 143 publications

One-Pot Synthesis of Amphiphilic Biopolymers from Oxidized Alginate and Self-Assembly as a Carrier for Sustained Release of Hydrophobic Drugs

One-Pot Synthesis of Amphiphilic Biopolymers from Oxidized Alginate and Self-Assembly as a Carrier for Sustained Release of Hydrophobic Drugs

Nanocarriers in Veterinary Medicine: A Challenge for Improving Osteosarcoma Conventional Treatments

Production of sphere-like bacterial cellulose in cultivation media with different carbon sources: a promising sustained release system of rifampicin

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