Polymer surface modification with monofunctional groups of variable types and densities

Friedrich, Jörg; Kühn, Gerhard; Mix, Renate; Fritz, Alexander T.; Schönhals, Andreas

doi:10.1163/156856103322396695

Cited by 72 publications

(78 citation statements)

References 26 publications

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“…Its existence is most probably a consequence of free radicals in the coating, which can react with oxygen after air contact. The -NH 2 /C ratio of 2-3 %, which is relatively low compared to the maximum value of 18 % reported for a special RF-plasma [15]. This is a consequence of cross-linking of the precursors and formation of different amines, amides, and nitriles, as demonstrated by FTIR analyses [16].…”

Section: Thermec 2009mentioning

confidence: 94%

Gas-Discharge Plasma-Assisted Functionalization of Titanium Implant Surfaces

Schröder

Finke

Polák

et al. 2010

MSF

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Abstract.A crucial factor for in-growth of metallic implants in the bone stock is the rapid cellular acceptance whilst prevention of bacterial adhesion on the surface. Such contradictorily adhesion events could be triggered by surface properties. There already exists fundamental knowledge about the influence of physicochemical surface properties like roughness, titanium dioxide modifications, cleanness, and (mainly ceramic) coatings on cell and microbial behavior in vitro and in vivo.The titanium surface can be equipped with antimicrobial properties by plasma-based copper implantation, which allows the release and generation of small concentrations of copper ions during contact with water-based biological liquids.Additionally, the titanium surface was equipped with amino groups by the deposition of an ultrathin plasma polymer. This coating on the one hand does not significantly reduce the generation of copper ions, and on the other hand improves the adhesion and spreading of osteoblast cells.The process development was accompanied by physicochemical surface analyses like XPS, FTIR, contact angle, SEM, and AFM. Very thin modified layers were created, which are resistant to hydrolysis and delamination. These titanium surface functionalizations were found to have either an antimicrobial activity or cell-adhesive properties. Intramuscular implantation of titanium samples coated with the cell-adhesive plasma polymer in rats revealed a reduced inflammation reaction compared to uncoated titanium.

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Section: Thermec 2009mentioning

confidence: 94%

Gas-Discharge Plasma-Assisted Functionalization of Titanium Implant Surfaces

Schröder

Finke

Polák

et al. 2010

MSF

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“…We have shown that ion irradiation leads to enhancement of the adsorption probability of metals on polymers. Like low-pressure plasma treatment, irradiation of a polymer surface with low-energy ions promotes its adhesion to metals [7,8,10]. Recently [9], we studied the metal-polymer adhesion at different fluences and observed a maximum in adhesion strength measured for Cu-PS system.…”

Section: Introductionmentioning

confidence: 98%

“…This effect presents a series of problems, because the ion fluence corresponding to the maximum peel strength is orders of magnitude below the fluence (>10 15 cm À2 ) at which saturation in surface functionalization and enhancement in polymer surface energy is reached [9]. Although the mechanisms of adhesion enhancement after plasma or ion beam pre-treatment have been discussed thoroughly in the last two decades, there is still only little known about the reason for the loss in adhesion above some ''critical level'' of pre-treatment [10]. Therefore, a lack of understanding about the processes that occur in a near-surface polymer layer during ion bombardment still remains, as well as about the kinetics of postbombardment chemical processes.…”

Section: Introductionmentioning

confidence: 99%

Effects of ion beam treatment on atomic and macroscopic adhesion of copper to different polymer materials

Zaporojtchenko

Zekonyte

Faupel

2007

Nuclear Instruments and Methods in Physics Research Section B:

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“…7,14,15 Klee et al 16 modified titanium by means of chemical vapor deposition (CVD)− polymerization of amino functionalized (2,2) paracyclophane. Friedrich et al 17 reported on polymer surface modifications with allylamine under chemical structure retention of the monomer and a relatively high amino group density (NH 2 /C = 18%) during pulsed plasma polymerization by radio frequency (RF) excitation. Kylian et al 18 followed a new strategy by depositing amino-rich thin films (NH 2 /C = 18%) using RF magnetron sputtering of nylon-6.6 in Ar/N 2 or N 2 /H 2 discharges.…”

Section: Introductionmentioning

confidence: 99%

Aging of Plasma-Polymerized Allylamine Nanofilms and the Maintenance of Their Cell Adhesion Capacity

et al. 2014

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The long-term stability and γ-sterilisability of bioactive layers is the precondition for the application of implants. Thus, aging processes of a microwave deposited, plasma polymerized allylamine nanofilm (PPAAm) with positively charged amino groups were evaluated concerning physicochemical characteristics and cell adhesion capacity over the course of one year. XPS, FT-IR, surface free energy, and water contact angle measurements elucidated not only the oxidation of the PPAAm film due to atmospheric oxygen reacting with surface free radicals but also the influence of atmospheric moisture during sample storage in ambient air. Surprisingly, within 7 days 70% of the primary amino groups are lost and mostly converted into amides. A positive zeta-potential was verified for half a year and longer. Increasing polar surface groups and a water contact angle shift from 60° to 40° are further indications of altered surface properties. Nevertheless, MG-63 human osteoblastic cells adhered and spread out considerably on aged and additionally γ-sterilized PPAAm layers deposited on polished titanium alloys (Ti-6Al-4V_P). These cell-relevant characteristics were highly significant over the whole period of one year and may not be related to the existence of primary amino groups. Rather, the oxidation products, the chemical amide group, that is, seem to support the attachment of osteoblasts at all times up to one year.

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Polymer surface modification with monofunctional groups of variable types and densities

Cited by 72 publications

References 26 publications

Gas-Discharge Plasma-Assisted Functionalization of Titanium Implant Surfaces

Gas-Discharge Plasma-Assisted Functionalization of Titanium Implant Surfaces

Effects of ion beam treatment on atomic and macroscopic adhesion of copper to different polymer materials

Aging of Plasma-Polymerized Allylamine Nanofilms and the Maintenance of Their Cell Adhesion Capacity

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