Polymer nanofibrous structures: Fabrication, biofunctionalization, and cell interactions

Beachley, Vince; Wen, Xuejun

doi:10.1016/j.progpolymsci.2010.03.003

Cited by 446 publications

(316 citation statements)

References 234 publications

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“…In general, hMSCs encapsulated within the hybrid gel adopted a spherical cell morphology, an equilibrium geometry assumed in the absence of microscale features or integrin binding sites, and typical of nanofi brous gels, such as alginate. [ 33 ] Although cells such as chondrocytes and osteoblasts are naturally rounded, [ 34 ] an adherent analogue would benefi t cells with fi broblastic or neuronal morphology and enable methodological fl exibility in printing complex, multiresponsive structures. This could be achieved by introducing cell-binding motifs; for instance, enhanced cell adhesion and spreading has been observed when alginate is covalently tagged with arginylglycylaspartic acid, a tripeptide sequence present in the cellular adhesion protein fi bronectin.…”

Section: Doi: 101002/adhm201600022mentioning

confidence: 99%

3D Bioprinting Using a Templated Porous Bioink

Armstrong

Burke

Carter

et al. 2016

Adv Healthcare Materials

159

111

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3D cell printing (bioprinting) is rapidly emerging as a key biofabrication strategy for engineering tissue constructs with physiological form and complexity. [1][2][3][4] In practice, this process involves layer-by-layer deposition of a cell-laden bioink resulting in the additive manufacture of a patterned architecture with different cell types, growth factors, or mechanical cues, which are positioned with far greater precision than can be achieved with conventional scaffold-based tissue engineering. [ 5 ] While there have been signifi cant advances in printing technology, [ 6,7 ] progress has been limited by the rate of development of bioinks that are compatible with both 3D printing and tissue engineering. [ 8 ] These materials must be able to withstand extrusion, maintain structural fi delity for long time periods, and permit adequate nutrient diffusion, all under cytocompatible conditions. Due to their intrinsic porosity and capacity for high nutrient loading, hydrogels are the most promising candidate for bioink design, [ 9 ] particularly when gelation can be externally triggered using chemical bonding, [ 10 ] photoinduced crosslinking, [ 11 ] thermal setting, [ 12 ] or shear-thinning. [ 13 ] However, integrating these factors into a system while maintaining printability, structural persistence, and cell viability, is an enduring challenge. [ 14 ] Pluronic block copolymers of poly(ethylene oxide-b-propylene oxide-b-ethylene oxide) present a possible pathway to print gelation, as they undergo a sol-gel transition upon heating near physiological temperatures. Here, elevating the temperature of these non-ionic surfactants reduces the

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Section: Doi: 101002/adhm201600022mentioning

confidence: 99%

3D Bioprinting Using a Templated Porous Bioink

Armstrong

Burke

Carter

et al. 2016

Adv Healthcare Materials

159

111

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“…Electrospinning is a versatile production method to produce porous fibers membranes with diameters ranging from few micrometers to several nanometers [7,8]. This process uses a high voltage source to inject charge of a certain polarity into a polymer solution or melt, which is then accelerated, in the form of a thin jet, and when the applied electric field is strong enough to overcome the surface tension of solution the jet is drawn into a fiber that is collected on a surface of a grounded target [9].…”

Section: Introductionmentioning

confidence: 99%

Effect of neutralization and cross-linking on the thermal degradation of chitosan electrospun membranes

Correia

Gámiz-González

Botelho

et al. 2014

J Therm Anal Calorim

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Thermal degradation of as electrospun chitosan membranes and samples subsequently treated with ethanol and cross-linked with glutaraldehyde (GA) have been studied by thermogravimetry (TG) coupled with an infrared spectrometer (FTIR). The influence of the electrospinning process and cross-linking in the electrospun chitosan thermal stability was evaluated. Up to three degradation steps were observed in the TG data, corresponding to water dehydration reaction at temperatures below 100 ºC, loss of side groups formed between the amine groups of chitosan and trifluoroacetic acid between 150 -270 ºC and chitosan thermal degradation that starts around 250 ºC and goes up to 400 ºC. The Kissinger model was employed to evaluate the activation energies of the electrospun membranes during isothermal experiments and revealed that thermal degradation activation energy increases for the samples processed by electrospinning and subsequent neutralization and cross-linking treatments with respect to the neat chitosan powder.

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“…The wettability of a polymer surface is then a result of both its surface chemistry and its topography 52 and it has been demonstrated that has a 80 strong influence on cell adhesion and proliferation. Cell morphology is another important characteristic in tissue engineering scaffold design as it allows the control of cell arrangement and the translational effects that cell morphology have on other cell functions 53 . Cell morphology can be 85 influenced by the surface substrate and can adopt different morphologies on fibrous membranes compared to film membranes 54 .…”

mentioning

confidence: 99%

Effect of poling state and morphology of piezoelectric poly(vinylidene fluoride) membranes for skeletal muscle tissue engineering

et al. 2013

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This work reports on the influence of polarization and morphology of electroactive poly(vinylidene fluoride), PVDF, on the biological response of myoblast cells. Non-poled, ''poled +'' and "poled-" -PVDF were prepared in the form of films. Further, random and aligned electrospun -PVDF fiber mats were also prepared. It is demonstrated that negatively charged surfaces improve cell adhesion and proliferation and that the directional growth of the myoblast cells can be achieved by the cell culture on oriented fibers. Therefore, 10 the potential application of electroative materials for muscle regeneration is demonstrated.

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Polymer nanofibrous structures: Fabrication, biofunctionalization, and cell interactions

Cited by 446 publications

References 234 publications

3D Bioprinting Using a Templated Porous Bioink

3D Bioprinting Using a Templated Porous Bioink

Effect of neutralization and cross-linking on the thermal degradation of chitosan electrospun membranes

Effect of poling state and morphology of piezoelectric poly(vinylidene fluoride) membranes for skeletal muscle tissue engineering

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