Effect of poling state and morphology of piezoelectric poly(vinylidene fluoride) membranes for skeletal muscle tissue engineering

Abstract

This work reports on the influence of polarization and morphology of electroactive poly(vinylidene fluoride), PVDF, on the biological response of myoblast cells. Non-poled, ''poled +'' and "poled-" -PVDF were prepared in the form of films. Further, random and aligned electrospun -PVDF fiber mats were also prepared. It is demonstrated that negatively charged surfaces improve cell adhesion and proliferation and that the directional growth of the myoblast cells can be achieved by the cell culture on oriented fibers. Therefore, 10 the potential application of electroative materials for muscle regeneration is demonstrated.

Influence of oxygen plasma treatment parameters on poly(vinylidene fluoride) electrospun fiber mats wettability

“…[3,6] PVDF has been used in various fields including tissue engineering, filtration, air cleaning, rechargeable batteries and sensors, among others. [5,[7][8] In particular, electrospun PVDF fiber mats have attracted a large interest due to their high surface area, small fiber diameters and porous structure. [5] However, the high hydrophobicity, poor wettability and low surface energy characteristic of PVDF are major drawbacks for several applications.…”

The effect of PVDF‐TrFE scaffolds on stem cell derived cardiovascular cells

“…Recently, poly (vinylidene) fluoride (PVDF) and its copolymer poly (vinylidene fluoride-trifluoroethylene) (PVDF-TrFE), both exhibiting piezoelectric characteristics, have been explored as potential scaffold materials for tissue engineering applications. Piezoelectric scaffolds possess the intrinsic property of producing an electrical voltage in response to mechanical deformation without the need for external power sources or electrodes (Damaraju et al, 2013;Lee and Arinzeh, 2012;Martins et al, 2013;Weber et al, 2010a). While the feasibility of PVDF-TrFE scaffolds for bone and neural cell studies have recently been demonstrated, the effect of PVDF-TrFE scaffolds on cardiovascular cells has not yet been explored.…”

Strategies for the development of three dimensional scaffolds from piezoelectric poly(vinylidene fluoride)

“…For both cytotoxicity studies were performed and results proved that the evaporation of solvent completely occurs once its non-toxic once it's non-inhibit the cell viability like MC3T3-E1 pre-osteoblast [22]. Moreover, cell culturing was performed and the solvent the results demonstrated that PVDF fibers dissolved in DMF solution promotes the cell adhesion, proliferation and differentiation [23].…”

“…Different techniques have been used to process PVDF and its polymer/composites based in different strategies (Table 1) to obtain various morphologies including micropillars [21], particles [20,22], films [23][24][25] and fibers [15,[26][27][28][29][30][31] in order to better suit specific tissue engineering strategies. Further, it has been shown that substrates based on PVDF have different influence on cell adhesion, proliferation and differentiation [7] depending on their morphology.…”