Polymer microring resonators for biochemical sensing applications

Chao, Chih‐Yu; Fung, Wayne Y.; Guo, L. Jay

doi:10.1109/jstqe.2005.862945

Cited by 379 publications

(58 citation statements)

References 26 publications

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“…Substrates and masters were heated to 130 °C and pressurized to 120 psi to precondition the polymer, followed by embossing at 140 °C and 500 psi for four minutes. In agreement with the previous literature, because of the aspect ratio between the waveguide structures and the thin polymer film, for many patterns higher pressure was needed than when imprinting other features [12,13]. Substrates were cleaved by marking the edge of the wafer onto which the polymer waveguides had been embossed using a diamond scribe, and carefully snapping the wafer along one of its crystal planes.…”

Section: Methodssupporting

confidence: 65%

“…There are a number of well developed techniques that permit direct label-free detection of bound target biomolecules [2], including optical [3–5], electrical [6], and acoustic sensors [7]. Within the broader class of label-free biosensors, optically resonant devices are particularly promising due to their ability to concentrate electromagnetic energy into small mode volumes, their capacity for multiplexed detections, and their ability to operate in aqueous environments [8–13]. A number of different architectures have been investigated in the development of optically resonant biosensors, including photonic crystals [5, 14], microtoroids [15], and microring/microracetracks [16,17].…”

Section: Introductionmentioning

confidence: 99%

“…At the other end of the spectrum, polymer optical biosensors offer low cost, simple fabrication, but suffer from lower sensitivities than silicon equivalents [10,12,13, 20–22]. Polymers are commercially available with a range of thermal, mechanical, and optical properties, and can be readily functionalized for the immobilization of biomolecular sensing agents [23].…”

Section: Introductionmentioning

confidence: 99%

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Nanoporous polymer ring resonators for biosensing

Mancuso¹,

Goddard²,

Erickson³

2011

Opt. Express

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Optically resonant devices are promising as label-free biomolecular sensors due to their ability to concentrate electromagnetic energy into small mode volumes and their capacity for multiplexed detection. A fundamental limitation of current optical biosensor technology is that the biomolecular interactions are limited to the surface of the resonant device, while the highest intensity of electromagnetic energy is trapped within the core. In this paper, we present nanoporous polymer optofluidic devices consisting of ring resonators coupled to bus waveguides. We report a 40% increase in polymer device sensitivity attributed to the addition of core energy- bioanalyte interactions.

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Section: Methodssupporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nanoporous polymer ring resonators for biosensing

Mancuso¹,

Goddard²,

Erickson³

2011

Opt. Express

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“…Among the various kinds of microresonators 9,10 made from semiconducting or dielectric materials those comprising rotational symmetry, such as spheres, 11 cylinders, 12 rings, 13 or toroids, 2,14 have attracted a lot of interest because they can be fabricated from a single material without any need for optical coatings. In such resonators, light is guided by total internal reflection ͑TIR͒, which implies that the traveling ray has to impinge onto the resonator/ambient interface with its refractive index contrast n = n res / n amb at an angle beyond the critical angle, ␣ crit = arcsin͑1 / n͒, for TIR.…”

Section: -8mentioning

confidence: 99%

Whispering gallery mode biosensor operated in the stimulated emission regime

François

Himmelhaus

2009

Applied Physics Letters

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“…[6][7][8] The sensing area is relatively smaller than those devices based on surface plasma resonance and diffractive grating. The microring resonator configuration consists of a ring waveguide sandwiched by two straight waveguides.…”

Section: Introductionmentioning

confidence: 99%

Nanophotonic biosensors using hexagonal nanoring resonators: computational study

Hsiao

Lee

2011

J. Micro/Nanolith. MEMS MOEMS

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The characteristics of biochemical sensors based on photonic crystal (PC) resonators are investigated in this work. The PC structure consists of holes arranged in a hexagonal lattice on a silicon slab. The nanoring resonator is formed by removing certain holes along a hexagonal trace. The hexagonal nanoring resonator is sandwiched by two PC waveguides that are formed by removing two lines of holes. The trapping of biomolecules, e.g., DNAs or proteins, in a functionalized sensing hole introduces a shift in resonant wavelength peak in the output terminal. We demonstrate two resonator designs: single and dual nanorings. The quality factor of the single nanoring resonator is 2400. The dual nanoring resonator reveals two different resonant modes. The propagated directions of dropped light for these two modes are antiparallel. The quality factors for these two resonant modes are 2100 and 1855, respectively. This dual nanoring resonator has a novel sensing mechanism, making it capable of simultaneously sensing two different biomolecules. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). IntroductionMicro-optical and nanophotonic sensing mechanisms for chemical and biochemical sensing applications have recently attracted considerable attention. For instance, integrated optical directional couplers 1 and photonic-crystal-based Bragg gratings 2 have already been adopted for chemical and biochemical sensing. Optical sensing is typically achieved by two mechanisms. The first mechanism relies on the detection of a change in refractive index of the homogeneous medium surrounding the sensing element in the optical sensors. The second sensing mechanism is surface sensing. The optical output characteristics are the function of the thickness of biomolecules immobilized on the surface of the optical sensors. 3-5 The label-free affinity-based optical biosensors allow us to study the selective binding between the target molecules and captured agents without using a fluorescence or radio label. Surface plasma resonance and colorimetric resonance in a diffractive grating surface have also been extensively employed in commercial label-free affinity-based optical biosensors. These sensors enable the detection of selective binding of biomolecules by measuring the change of refractive index on the surface. However, the sensing area of these sensors are usually in mm 2 scale and not convenient for trace sensing.Waveguide-based microring resonator have also received much attention in sensing applications. 6-8 The sensing area is relatively smaller than those devices based on surface plasma resonance and diffractive grating. The microring resonator configuration consists of a ring waveguide sandwiched by two straight waveguides. These two waveguides are commonly referred to as bus and drop waveguides, respectively.

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Polymer microring resonators for biochemical sensing applications

Cited by 379 publications

References 26 publications

Nanoporous polymer ring resonators for biosensing

Nanoporous polymer ring resonators for biosensing

Whispering gallery mode biosensor operated in the stimulated emission regime

Nanophotonic biosensors using hexagonal nanoring resonators: computational study

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