Nanoporous polymer ring resonators for biosensing

Mancuso, Matthew; Goddard, Julie M.; Erickson, David

doi:10.1364/oe.20.000245

Cited by 29 publications

(26 citation statements)

References 25 publications

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“…They are fabricated on-chip with photolithographic techniques in different materials systems and in large sensor arrays [24, 40, 50, 52, 53, 89, 130, 131, 162–168]. For example, ring, racetrack and disk resonators can be fabricated in silica, silicon [24, 50, 89, 111, 166, 168] and organic polymers [52, 165, 167, 169, 170]. Early biosensing demonstrations proposed a high-finesse (low loss) WGM disk resonator [130] and utilized a vertically coupled glass microring resonator with Q of about 12000 [111] as well an integrated silicon nitride (Si x N y /SiO 2 ) ring resonator [53].…”

Section: Optical Resonator Biosensors: Materials and Geometriesmentioning

confidence: 99%

“…The electrically tunable tracing microring thus eliminates the need for wavelength scanning of a laser source [171]. Nanoporous polymer ring resonators reportedly increase device sensitivity by 40% because bioanalyte enter pores and interact with electromagnetic energy in the core of the ring, not just its surface [169]. Cascaded microrings that exploit the Vernier effect have also recently been proposed to increase sensitivity [172, 173].…”

Section: Optical Resonator Biosensors: Materials and Geometriesmentioning

confidence: 99%

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Review Label-free detection with high-Q microcavities: a review of biosensing mechanisms for integrated devices

2012

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Optical microcavities that confine light in high-Q resonance promise all of the capabilities required for a successful next-generation microsystem biodetection technology. Label-free detection down to single molecules as well as operation in aqueous environments can be integrated cost-effectively on microchips, together with other photonic components, as well as electronic ones. We provide a comprehensive review of the sensing mechanisms utilized in this emerging field, their physics, engineering and material science aspects, and their application to nanoparticle analysis and biomolecular detection. We survey the most recent developments such as the use of mode splitting for self-referenced measurements, plasmonic nanoantennas for signal enhancements, the use of optical force for nanoparticle manipulation as well as the design of active devices for ultra-sensitive detection. Furthermore, we provide an outlook on the exciting capabilities of functionalized high-Q microcavities in the life sciences.

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Section: Optical Resonator Biosensors: Materials and Geometriesmentioning

confidence: 99%

Section: Optical Resonator Biosensors: Materials and Geometriesmentioning

confidence: 99%

Review Label-free detection with high-Q microcavities: a review of biosensing mechanisms for integrated devices

2012

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“…Freestanding high-Q microcavities were also demonstrated to show highly sensitive resonances in an aqueous environment with possible applications for biosensing [32]. A recent example for this approach is the use of nanoporous polymer ring resonators that allow molecular targets to penetrate into the resonator volume for increased light-target interaction and increased sensitivity [33]. A more recent trend in the resonator arena is the combination of optofluidics and (cavity) optomechanics, which focuses on the interaction of light with mechanically resonant structures [34].…”

Section: Reconfigurable Optofluidic Devices and Systemsmentioning

confidence: 99%

Optofluidic bioanalysis: fundamentals and applications

et al. 2017

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Over the past decade, optofluidics has established itself as a new and dynamic research field for exciting developments at the interface of photonics, microfluidics, and the life sciences. The strong desire for developing miniaturized bioanalytic devices and instruments, in particular, has led to novel and powerful approaches to integrating optical elements and biological fluids on the same chip-scale system. Here, we review the state-of-the-art in optofluidic research with emphasis on applications in bioanalysis and a focus on waveguide-based approaches that represent the most advanced level of integration between optics and fluidics. We discuss recent work in photonically reconfigurable devices and various application areas. We show how optofluidic approaches have been pushing the performance limits in bioanalysis, e.g. in terms of sensitivity and portability, satisfying many of the key requirements for point-of-care devices. This illustrates how the requirements for bianalysis instruments are increasingly being met by the symbiotic integration of novel photonic capabilities in a miniaturized system.

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“…Mach-Zehnder interferometers [6,7], optical ring resonators [8,9], photonic crystal cavity resonators [10], and techniques exploiting local surface-plasmon-resonance (LSPR) in metal nano-particles are promising. Some are even reported to sense changes in refractive index corresponding to a single molecule [5,9,11,12].…”

Section: Introductionmentioning

confidence: 99%

Detection of single nano-defects in photonic crystals between crossed polarizers

Grepstad¹,

Kaspar²,

Johansen³

et al. 2013

Opt. Express

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Abstract:We investigate, by simulations and experiments, the light scattering of small particles trapped in photonic crystal membranes supporting guided resonance modes. Our results show that, due to amplified Rayleigh small particle scattering, such membranes can be utilized to make a sensor that can detect single nano-particles. We have designed a biomolecule sensor that uses cross-polarized excitation and detection for increased sensitivity. Estimated using Rayleigh scattering theory and simulation results, the current fabricated sensor has a detection limit of 26 nm, corresponding to the size of a single virus. The sensor can potentially be made both cheap and compact, to facilitate use at point-of-care.

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Nanoporous polymer ring resonators for biosensing

Cited by 29 publications

References 25 publications

Review Label-free detection with high-Q microcavities: a review of biosensing mechanisms for integrated devices

Review Label-free detection with high-Q microcavities: a review of biosensing mechanisms for integrated devices

Optofluidic bioanalysis: fundamentals and applications

Detection of single nano-defects in photonic crystals between crossed polarizers

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