Polymer-lipid hybrid nanoparticles as enhanced indomethacin delivery systems

Dalmoro, Annalisa; Bochicchio, Sabrina; Nasibullin, Shamil F.; Bertoncin, Paolo; Lamberti, Gaetano; Barba, Anna Angela; Moustafine, Rouslan I.

doi:10.1016/j.ejps.2018.05.014

Cited by 50 publications

(32 citation statements)

References 27 publications

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“…Uncoated ones ( Figure 6A) appeared nanometric, spherical, and with a smooth surface. The chitosan coating by a simil-microfluidic technique ( Figure 6B) did not alter the liposome's shape, and the coating layer was clearly visualized on its surface, as already seen in previous works [2,16]. Nanolipid structures coated by 0.01% polycation were characterized in terms of their morphology by TEM images, mucoadhesiveness by a mucin binding assay, and stability by turbidimetry.…”

Section: Characterization Of Coated Nanolipid Structuressupporting

confidence: 77%

“…Uncoated ones ( Figure 6A) appeared nanometric, spherical, and with a smooth surface. The chitosan coating by a simil-microfluidic technique ( Figure 6B) did not alter the liposome's shape, and the coating layer was clearly visualized on its surface, as already seen in previous works [2,16]. The TEM image of uncoated vegan liposomes ( Figure 7A) showed a less defined shape (still spherical), which was due, perhaps, to the lack of the stabilizing action of cholesterol.…”

Section: Characterization Of Coated Nanolipid Structuressupporting

confidence: 77%

“…Uncoated and polycation-coated nanolipid structures were produced by the simil-microfluidic method, detailed in previous works [2,16,17]. The same principles of interdiffusion between two phases are applied in the production and covering steps for both nanovesicles.…”

Section: Production Of Uncoated and Polycation-coated Nanolipid Strucmentioning

confidence: 99%

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Coating of Nanolipid Structures by a Novel Simil-Microfluidic Technique: Experimental and Theoretical Approaches

Barba

Bochicchio²,

Bertoncin

et al. 2019

Coatings

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Nanolipid vesicular structures are ideal candidates for the controlled release of various ingredients, from vitamins for nutraceutical purposes to chemoterapic drugs. To improve their stability, permeability, and some specific surface properties, such as mucoadhesiveness, these structures can require a process of surface engineering. The interaction of lipid vesicles with oppositely charged polyelectrolytes seems to be an interesting solution, especially when the negatively charged liposomes are complexed with the cationic chitosan. In this work, a novel simil-microfluidic technique was used to produce both chitosan-coated vesicles and a vegan alternative composed of cholesterol-free liposomes coated by Guar Hydroxypropyltrimonium Chloride (Guar-HC). The combination between the experimental approach, based on experimental observations in terms of Z-potential, and size evolutions, and the theoretical approach, based on concepts of saturation, was the methodology applied to define the best polycation concentration to fairly cover (vegan or not) liposomes without aggregation. The smart production of coated nanolipid structures was confirmed by characterizations of morphology, mucoadhesiveness, and stability.

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Section: Characterization Of Coated Nanolipid Structuressupporting

confidence: 77%

“…Uncoated ones ( Figure 6A) appeared nanometric, spherical, and with a smooth surface. The chitosan coating by a simil-microfluidic technique ( Figure 6B) did not alter the liposome's shape, and the coating layer was clearly visualized on its surface, as already seen in previous works [2,16]. The TEM image of uncoated vegan liposomes ( Figure 7A) showed a less defined shape (still spherical), which was due, perhaps, to the lack of the stabilizing action of cholesterol.…”

Section: Characterization Of Coated Nanolipid Structuressupporting

confidence: 77%

See 1 more Smart Citation

Coating of Nanolipid Structures by a Novel Simil-Microfluidic Technique: Experimental and Theoretical Approaches

Barba

Bochicchio²,

Bertoncin

et al. 2019

Coatings

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“…In order to produce antioxidant-loaded liposomal vesicles, a novel semicontinuous simil-microfluidic apparatus (piping representation in Figure 1 [38]), the layout, operative conditions, and phenomenological aspects of which are detailed in [37][38][39], was used. Briefly, it consists of two feed solutions (lipids/ethanol and water) which are pushed through peristaltic pumps (into the production section, a millimetric tubular device where the interdiffusion of the two flows leads to the formation of liposomes directly at nanometric scale.…”

Section: Manufacturing Techniquementioning

confidence: 99%

“…The novel method, characterized by laminar flow conditions and diffusive mass transfer, allows the formation of homogeneous liposomes directly at nanometric scale as a consequence of the molecular interdiffusion between the water and the lipid/ethanol phases, as described in depth in [37,39]. In particular, by using a volumetric flow rate ratio of 10:1 (Vhs/Vls) and 5 mg/mL lipids in the final hydroalcoholic solution, it was possible to achieve a massive production of uniform nanometric vesicles (84 nm-145 nm size range) with high encapsulation efficiencies of vitamin D3, K2, E, and curcumin (88-98% range e.e.)…”

Section: Manufacturing Issuesmentioning

confidence: 99%

Simil-Microfluidic Nanotechnology in Manufacturing of Liposomes as Hydrophobic Antioxidants Skin Release Systems

Bochicchio¹,

Dalmoro

Simone

et al. 2020

Cosmetics

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Novel nanotechnologies represent the most attractive and innovative tools to date exploited by cosmetic companies to improve the effectiveness of their formulations. In this context, nanoliposomes have had a great impact in topical preparations and dermocosmetics, allowing the transcutaneous penetration and absorption of several active ingredients and improving the stability of sensitive molecules. Despite the recent boom of this class of delivery systems, their industrial production is still limited by the lack of easily scalable production techniques. In this work, nanoliposomes for the topical administration of vitamin D3, K2, E, and curcumin, molecules with high antioxidant and skin curative properties but unstable and poorly absorbable, were produced through a novel simil-microfluidic technique. The developed high-yield semi continuous method is proposed as an alternative to face the problems linked with low productive conventional methods in order to produce antioxidant formulations with improved features. The novel technique has allowed to obtain a massive production of stable antioxidant vesicles of an 84–145 nm size range, negatively charged, and characterized by high loads and encapsulation efficiencies. The obtained products as well as the developed high-performance technology make the achieved formulations very interesting for potential topical applications in the cosmetics/cosmeceutical field.

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Encapsulation and Delivery of Nutraceuticals and Bioactive Compounds by Nanoliposomes and Tocosomes as Promising Nanocarriers

Shahgholian

2022

Handbook of Nutraceuticals and Natural Products

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Polymer-lipid hybrid nanoparticles as enhanced indomethacin delivery systems

Cited by 50 publications

References 27 publications

Coating of Nanolipid Structures by a Novel Simil-Microfluidic Technique: Experimental and Theoretical Approaches

Coating of Nanolipid Structures by a Novel Simil-Microfluidic Technique: Experimental and Theoretical Approaches

Simil-Microfluidic Nanotechnology in Manufacturing of Liposomes as Hydrophobic Antioxidants Skin Release Systems

Encapsulation and Delivery of Nutraceuticals and Bioactive Compounds by Nanoliposomes and Tocosomes as Promising Nanocarriers

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