Polymer Embedded Nanocrystalline Titania Sorbent for ⁹⁹Mo-^99mTc Generator

Abstract

A new sorbent material, polymer embedded nano crystalline titania (Titanium Polymer-TiP) has been developed, from titanium (IV) chloride and isopropyl alcohol, for the adsorption of 99Mo, which is a precursor to 99mTc, a workhorse in radio-pharmaceuticals. The infrared absorption spectra of the TiP showed peaks corresponding to Ti-O groups. X-ray diffraction pattern of the adsorbent corresponded to rutile TiO2. The surface area of this polymer was 30 m2/g with an average pore size of 40 nm. The average crystallite size of TiO2, embedded in polymer, was found to be 5 nm. TEM micrograph of the adsorbent revealed the network of polymer with dispersed titania phase. Potential of this adsorbent for the preparation of 99Mo-99mTc generator has been explored. 99Mo could be adsorbed on to the adsorbent column containing TiP at pH 1 from which 99mTC could be eluted with normal (0.9%) saline solution with an elution yield of approximately 80%. The quality of the 99mTcO4 obtained was in accordance with the international specifications applicable for radiopharmaceutical use. A process demonstration run was carried out with 1.1 GBq (30 mCi) 99Mo activity level making use of the above adsorbent and consistent results were obtained over a period of one week, which is generally the shelf life of 99MO-99mTC generator.

Polymer Embedded Nanocrystalline Titania: A New Generation Sorbent for the Separation of 77As from Ge for Biomedical Applications

“…Nanomaterial based sorbents which have very high sorption capacity per unit mass owing to high surface area-to-volume ratio and intrinsic surface reactivity, are the most promising a Activity was measured after allowing the irradiated target to cool for 1 day Fig. 7 Recovery of Ge from the used TiP column materials as column matrices and TiP developed and explored by us earlier [24,25] [30]. Except 71 Ge (t = 11.2 days), the other activated Ge radionuclides are short-lived.…”

“…TiP was synthesized in situ by the reaction of TiCl 4 and isopropyl alcohol in 2:1 stoichiometric ratio, as reported by us earlier [24].…”

“…We have been working on the preparation of nanomaterials for applications in radionuclide separation and have achieved good success [24][25][26][27][28][29]. Our recent success in the utilization of polymer embedded nano-crystalline titania (TiP) [24,25] in the preparation of 99 Mo/ 99m Tc and 188 W/ 188 Re generators inspired us to evaluate its usefulness for accessing 77 As from thermal neutron irradiated natural germanium oxide.…”

“…Our recent success in the utilization of polymer embedded nano-crystalline titania (TiP) [24,25] in the preparation of 99 Mo/ 99m Tc and 188 W/ 188 Re generators inspired us to evaluate its usefulness for accessing 77 As from thermal neutron irradiated natural germanium oxide. To the best of our knowledge, no attempt has been made so far to separate 77 As using nanomaterial based sorbents.…”

Indigenous technology development and standardization of the process for obtaining ready to use sterile sodium pertechnetate-Tc-99m solution from Geltech generator

“…This is a new adsorbent material having higher adsorption capacity for Mo-99 (200 mg/g of PZC). Scientist in Bhabha Atomic Research Centre (BARC) has also reported about nano-zirconia, titania, and γ-alumina[678] adsorbent material for adsorption of molybdenum with higher adsorption capacities for preparing Mo-99/Tc-99m column generator.…”