Polymer-conjugated albumin and fibrinogen composite hydrogels as cell scaffolds designed for affinity-based drug delivery

Oss-Ronen, Liat; Seliktar, Dror

doi:10.1016/j.actbio.2010.07.017

Cited by 49 publications

(32 citation statements)

References 37 publications

(63 reference statements)

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“…Block copolymeric networks have also been formed based on polyesters, for instance, polylactide (PLA) and poly‐lactide‐co‐glycolide (PLGA), frequently with poly(ethylene glycol) (PEG) as a copolymer . Synthetic injectable hydrogels, however, may cause more severe immunologic reactions than natural polymer based materials and show a lower degradability rate …”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive hydrogels from BSA esterified with low molecular weight PEG

Wang

Buschle‐Diller

2014

J of Applied Polymer Sci

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Bovine serum albumin (BSA) and low molecular weight polyethylene glycol (PEG) were reacted in a single-step reaction to synthesize translucent hydrogels with a sol-gel transition at temperatures between 37 and 40 C. Gelation occurred by aggregation of smaller assemblies of BSA-PEG precursors within minutes. The sol-gel transition concentration depended on the molecular weight of PEG only at temperatures below 35 C; above 45 C phase separation occurred and a precipitate formed. Microscopic examination showed the porous structure of the gels. At a fairly low grafting ratio, BSA preserved its native secondary and tertiary structure and maintained its capability for binding and enclosing small molecules. Drug delivery was assessed by a discontinuous method in vitro using 5-fluorouracil. Degradation tests with trypsin confirmed that the hydrogels were biodegradable. This novel material holds promise for biomedical applications as potentially injectable drug delivery vehicle.

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Section: Introductionmentioning

confidence: 99%

Thermoresponsive hydrogels from BSA esterified with low molecular weight PEG

Wang

Buschle‐Diller

2014

J of Applied Polymer Sci

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“…It is water soluble beyond its isoelectric point, that is, at pH 4.7, and below its temperature of denaturation, that is 60 °C. In the blood stream, it is known to have a unique binding affinity to various drugs and proteins, including fatty acids, hormones, metal ions, and other bioactive compounds . Several studies have been conducted to use serum albumin as a hydrogel constituent mostly in chemically crosslinked hydrogels but none of those have focused on incorporating such biomolecules in the physically crosslinked ones.…”

Section: Introductionmentioning

confidence: 99%

“…Uses of hydrogels have been increasingly attractive in biomedical applications. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] To be more specific, research studies in drug delivery and tissue engineering frequently focus on injectable hydrogels due to their particularly unique phase transitions. [4,7,8,[11][12][13][14][15][16][17] .…”

Section: Introductionmentioning

confidence: 99%

Albumin-Conjugated pH/Thermo Responsive Poly(amino urethane) Multiblock Copolymer as an Injectable Hydrogel for Protein Delivery

Manokruang

Lee

2013

Macromol. Biosci.

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Albumin-conjugated pH and thermo responsive poly(amino urethane) multiblock copolymers are synthesized. The aqueous solution of the conjugate exhibits pH/temperature dependent sol-gel phase transitions that can be tuned by changing solution concentration and albumin composition. The gel window well covers the physiological condition allowing the flowing liquid to readily form the solid gel under the back of the Sprangue-Dawley (SD) rats. The release profile of lysozyme, as a model protein, shows that the conjugate hydrogel is able to effectively reduce the burst effect, in vivo, and maintain the sustained release of lysozyme over 4 and 2 weeks in the in vitro and in vivo experiments, respectively. Such conjugate hydrogel can be considered as a potential candidate for long-term delivery of proteins.

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“…61 PEGylated albumin combined with PEGylated Fbg hydrogel was shown to reveal comprehensive drug release and degradation properties. 72 Macro/microporous biphasic calcium phosphate granules combined with Fbn glue were shown to provide a moldable and selfhardening biocomposite, which has been used in types of orthopedic and maxillofacial applications, due to their osteoconductive properties. 73 Fbn-PLGA composites were shown to encourage early chondrogenesis in rabbit articular cartilage, and this indicates that Fbn-PLGA might act as a possible cell delivery vehicle to promote articular cartilage development.…”

Section: Fbg and Fbn Tubes As Vascular Graftmentioning

confidence: 99%

Fibrinogen and fibrin based micro and nano scaffolds incorporated with drugs, proteins, cells and genes for therapeutic biomedical applications

Rajangam¹,

An²

2013

IJN

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Over the past two decades, many types of natural and synthetic polymer-based micro-and nanocarriers, with exciting properties and applications, have been developed for application in various types of tissue regeneration, including bone, cartilage, nerve, blood vessels, and skin. The development of suitable polymers scaffold designs to aid the repair of specific cell types have created diverse and important potentials in tissue restoration. Fibrinogen (Fbg)-and fibrin (Fbn)-based micro-and nanostructures can provide suitable natural matrix environments. Since these primary materials are abundantly available in blood as the main coagulation proteins, they can easily interact with damaged tissues and cells through native biochemical interactions. Fbg-and Fbn-based micro and nanostructures can also be consecutively furnished/ or encapsulated and specifically delivered, with multiple growth factors, proteins, and stem cells, in structures designed to aid in specific phases of the tissue regeneration process. The present review has been carried out to demonstrate the progress made with micro and nanoscaffold applications and features a number of applications of Fbg-and Fbn-based carriers in the field of biomaterials, including the delivery of drugs, active biomolecules, cells, and genes, that have been effectively used in tissue engineering and regenerative medicine.

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Polymer-conjugated albumin and fibrinogen composite hydrogels as cell scaffolds designed for affinity-based drug delivery

Cited by 49 publications

References 37 publications

Thermoresponsive hydrogels from BSA esterified with low molecular weight PEG

Thermoresponsive hydrogels from BSA esterified with low molecular weight PEG

Albumin-Conjugated pH/Thermo Responsive Poly(amino urethane) Multiblock Copolymer as an Injectable Hydrogel for Protein Delivery

Fibrinogen and fibrin based micro and nano scaffolds incorporated with drugs, proteins, cells and genes for therapeutic biomedical applications

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