Polymer Composites Containing Gated Mesoporous Materials for On-Command Controlled Release

Abstract

Polyamidic nanofibrous membranes containing gated silica mesoporous particles, acting as carriers, are described as novel hybrid composite materials for encapsulation and oncommand delivery of garlic extracts. The carrier system consists of MCM-41 solids functionalized in the outer surface, with linear polyamines (Solid P1) and with hydrolyzed starch (Solid P2), both acting as molecular gates. Those particles were adsorbed on electospun nylon-6 nanofibrous membranes yielding to composite materials M1 and M2. FE-SEM analysis confirmed the presence of particles incorporated on the nylon nanofibers. The release of the entrapped molecules (garlic extract) from the P1, P2, M1 and M2 materials was evaluated using 2 cyclic voltammetry measurements. Electrochemical studies showed that at acidic pH P1 and M1 were unable to release their entrapped cargo (closed gate), whereas at neutral pH both materials release their loading (open gate). Dealing with P2 and M2 materials, in the absence of pancreatin a negligible release is observed (closed gate), whereas in the presence of enzyme the load is freely to diffuse to the solution. These newly developed composite nanomaterials, provide a homogeneous easy-to-handle system with controlled delivery and bioactive-protective features, having potential applications on pharmacology, medical and engineering fields INTRODUCTION

Structured Biodegradable Polymeric Microparticles for Drug Delivery Produced Using Flow Focusing Glass Microfluidic Devices

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Mesoporous silica materials for controlled delivery based on enzymes

“…The microparticles loaded with garlic extract and capped with Glucidex 47 were also prepared by the same authors. 73 The capped material was embedded into a nylon-6 membrane and the release properties of the nanocomposite were tested in the presence of pancreatin, which hydrolysed starch and aimed cargo delivery.…”

Synthesis of the mesostructured polymer-silica composite and silicon dioxide through polymer swelling in silica precursor

“…The possibility of using polymer-silica composites to tailor the textural properties of silica could potentially be of considerable value for new silica applications within above mentioned fields of interest (Kierys et al 2014;Acosta et al 2014). Many factors influence the formation of siliceous network, including the 3D configuration of SiO 2 tetrahedra.…”