Polymer Blended Deproteinized Natural Rubber Reservoirs for Nicotine Transdermal Patches: In vitro Drug Release, Permeation Study, and Stability Test

Pichayakorn, Wiwat; Suksaeree, Jirapornchai; Taweepreda, Wirach; Ritthidej, Garnpimol C.

doi:10.1007/s10924-021-02251-x

Cited by 6 publications

(2 citation statements)

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“…10 Some researchers were attributed to the application of DPNR in transdermal patches. [11][12][13][14][15][16] However, the removal of proteins will lead to a decrease on the tensile strength of NR, which makes the fabrication of high-performance DPNR even more challenging. 17,18 Introducing rigid nano-fillers is an effective way to reinforce and functionalize the rubber materials.…”

Section: Introductionmentioning

confidence: 99%

“…Deproteinized natural rubber (DPNR) latex can not only effectively avoid or minimize health risks resulted from the latex allergies, but also possess better film forming property 10 . Some researchers were attributed to the application of DPNR in transdermal patches 11–16 . However, the removal of proteins will lead to a decrease on the tensile strength of NR, which makes the fabrication of high‐performance DPNR even more challenging 17,18 …”

Section: Introductionmentioning

confidence: 99%

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Preparation of high‐performance deproteinized natural rubber/chitosan composite films via a green and sulfur‐free method

Yuan

Sun

Tian

et al. 2022

J of Applied Polymer Sci

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To solve the environment and health issues arose from the sulfur vulcanization, a facile and completely eco-friendly method of latex-assembly and in situ cross-linking is developed to prepare fully bio-based and high-performance rubber films. The films are featured by a "reinforced concrete" structure composed of dynamically cross-linked chitosan framework and unvulcanized deproteinized natural rubber (DPNR) matrix. The self-assembly of DPNR latex particles and chitosan, as well as the in situ cross-linking of chitosan in the film forming process are confirmed by transmission electron microscope and dynamic light scattering. As green rubbers without vulcanization, the asdesigned composite films possess excellent mechanic properties comparable to those of the sulfur vulcanized DPNR film, whose tensile strength and toughness reach 15.2 MPa and 77.6 MJ m À3 respectively. Moreover, the films exhibited appropriate permeability to moisture and achievable reprocessing, which have potential applications in wearable devices.

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