Formulation Design of Oral Strip-Films Based on PVA/PVP Polymer Blends for Nicotine Delivery

Pichayakorn, Wiwat; Maneewattanapinyo, Pattwat; Panrat, Kamon; Monton, Chaowalit; Suksaeree, Jirapornchai

doi:10.1007/s10924-022-02527-w

Cited by 5 publications

(3 citation statements)

References 39 publications

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“…blank film through its main semi-crystalline characteristics (Figure 12b). Strong intramolecular and intermolecular hydrogen connections exist between PVA and the main chain because of the OH groups' binding to the major chain [24,25]. In this study, because the silver-nanoparticle-complexed G. applanatum was present in significantly lower amounts than the blank film in the topical film, the topical film showed a semicrystalline structure that was more closely related to the characteristics of the blank film (Figure 12c).…”

Section: Tgamentioning

confidence: 64%

“…Folding the film sample repeatedly in the same area until it broke was used to test its folding endurance. The folding endurance was determined by counting the number of folds carried out before the film sample broke [24,25]. FTIR Spectrum FTIR spectrometer (Vertex70, Bruker, Berlin, Germany) was used to examine the sample.…”

Section: G Applanatum Folding Endurancementioning

confidence: 99%

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Effect of Ionic Liquid on Silver-Nanoparticle-Complexed Ganoderma applanatum and Its Topical Film Formulation

et al. 2023

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Imidazolium-based ionic liquids have been widely utilized as versatile solvents for metal nanoparticle preparation. Silver nanoparticles and Ganoderma applanatum have displayed potent antimicrobial activities. This work aimed to study the effect of 1-butyl-3-methylimidazolium bromide-based ionic liquid on the silver-nanoparticle-complexed G. applanatum and its topical film. The ratio and conditions for preparation were optimized by the design of the experiments. The optimal ratio was silver nanoparticles: G. applanatum extract: ionic liquid at 97:1:2, and the conditions were 80 °C for 1 h. The prediction was corrected with a low percentage error. The optimized formula was loaded into a topical film made of polyvinyl alcohol and Eudragit®, and its properties were evaluated. The topical film was uniform, smooth, and compact and had other desired characteristics. The topical film was able to control the release of silver-nanoparticle-complexed G. applanatum from the matrix layer. Higuchi’s model was used to fit the kinetic of the release. The skin permeability of the silver-nanoparticle-complexed G. applanatum was improved by about 1.7 times by the ionic liquid, which might increase solubility. The produced film is suitable for topical applications and may be utilized in the development of potential future therapeutic agents for the treatment of diseases.

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Section: Tgamentioning

confidence: 64%

Section: G Applanatum Folding Endurancementioning

confidence: 99%

Effect of Ionic Liquid on Silver-Nanoparticle-Complexed Ganoderma applanatum and Its Topical Film Formulation

et al. 2023

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“…The number of folds a film sample could withstand in one location before breaking was examined. Calculating a film sample's folding endurance involved counting how many folds it could endure before snapping [12][13][14].…”

Section: Methodsmentioning

confidence: 99%

Mechanical Design Optimization of Capsaicin Extract-Loaded Topical Films Using Design of Experiments Approach

Suksaeree,

Monton,

Pichayakorn

2023

MSF

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We evaluated and optimized the mechanical characteristics of capsaicin extract-loaded topical films using the Design-Expert® software version 11. Dependent variables included UTS, elongation at break, and folding endurance, whereas independent variables included EC, capsaicin extracts, and TEC. While a quadratic model provided a more accurate prediction of elongation at break, the best linear correlation was found for both UTS and folding endurance. The DoE estimated that the proportion of EC, capsaicin extracts, and TEC would be 2.3: 1.4: 2.4. The model was proved to be acceptable for forecasting results inside the design space without the requirement for additional trials by demonstrating that the ratio's value of prediction was more than 4. UTS, elongation at break, and folding endurance experimental values were 70.50±4.53 MPa, 41.10±10.18%, and 101±6 folds, respectively. The calculated percent errors were 9.25%, 9.20%, and 9.49%, respectively. The DoE from Design-Expert® software successfully proved a low percent error of the prediction—less than 10%—and this was satisfactory and accepted for designing in drug delivery systems.

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Plant leaf mucilage/carrageenan/Eudragit® NE30D blended films: Optimization, characterization, and pharmaceutical application

Maneewattanapinyo,

Monton,

Pichayakorn

et al. 2024

International Journal of Biological Macromolecules

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Formulation Design of Oral Strip-Films Based on PVA/PVP Polymer Blends for Nicotine Delivery

Cited by 5 publications

References 39 publications

Effect of Ionic Liquid on Silver-Nanoparticle-Complexed Ganoderma applanatum and Its Topical Film Formulation

Effect of Ionic Liquid on Silver-Nanoparticle-Complexed Ganoderma applanatum and Its Topical Film Formulation

Mechanical Design Optimization of Capsaicin Extract-Loaded Topical Films Using Design of Experiments Approach

Plant leaf mucilage/carrageenan/Eudragit® NE30D blended films: Optimization, characterization, and pharmaceutical application

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