Polymer-Based Ion Trap Chemical Sensor

Yu, Meng; Fico, Miriam; Kothari, Sameer; Ouyang, Zheng; Chappell, William J.

doi:10.1109/jsen.2006.883853

Cited by 23 publications

(19 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With the knowledge gained from the studies described above, a paper spray cartridge was designed and fabricated using SLA (stereo lithography apparatus)[45]. SLA resin Nanoform 15120 (DSM Somos) was chosen as the cartridge material as it has a high glass-transition temperature and is relatively chemically inert, especially to organic solvents[46].…”

Section: Resultsmentioning

confidence: 99%

Paper spray ionization devices for direct, biomedical analysis using mass spectrometry

Yang

Wang

Maas

et al. 2012

International Journal of Mass Spectrometry

Self Cite

185

166

View full text Add to dashboard Cite

Paper spray ionization has been developed as a direct, fast and low-cost sampling and ionization method for qualitative and quantitative mass spectrometric (MS) analysis of complex mixtures. Analyte ions are generated by applying a high voltage and a small volume (~10 μL) of spray solvent onto a porous substrate. The sample can be preloaded onto the paper or mixed into the spray solution. The geometry of the paper and the method of supplying the necessary internal standard are important factors that affect the ionization efficiency and subsequently the sensitivity and quantitation accuracy of the analytical data. As the cut angle of the paper tip is changed, the spray plume, the total spray current and the electric field intensity at the tip all vary correspondingly, with resulting differences in signal intensity. Sample load is another important factor for obtaining a stable MS signal and accurate quantitative results. The optimal sample load was found to be dependent on the paper size. The dissolution and spray process was also investigated and analyte transfer on paper was shown to be largely associated with bulk solution flow towards the spray tip. The information gathered from these systematic studies provides guidance for the design and optimization of a disposable sample cartridge for paper spray MS, a device which potentially is suitable for fast clinical analysis, especially for point-of-care diagnostics.

show abstract

Section: Resultsmentioning

confidence: 99%

Paper spray ionization devices for direct, biomedical analysis using mass spectrometry

Yang

Wang

Maas

et al. 2012

International Journal of Mass Spectrometry

Self Cite

185

166

View full text Add to dashboard Cite

show abstract

“…19b and c). A polymer-based ion trap has been fabricated by stereolithography (SLA) which provides precise monolithic fabrication (Yu et al, 2006). This device is based on a rectilinear ion trap (RIT) model which is composed of four flat plates, so that this simple structure is easily amenable to microfabrication techniques.…”

Section: A Ion Trapsmentioning

confidence: 99%

Microchip technology in mass spectrometry

Sikanen

Franssila

Kauppila

et al. 2009

Mass Spectrom. Rev.

View full text Add to dashboard Cite

Microfabrication of analytical devices is currently of growing interest and many microfabricated instruments have also entered the field of mass spectrometry (MS). Various (atmospheric pressure) ion sources as well as mass analyzers have been developed exploiting microfabrication techniques. The most common approach thus far has been the miniaturization of the electrospray ion source and its integration with various separation and sampling units. Other ionization techniques, mainly atmospheric pressure chemical ionization and photoionization, have also been subject to miniaturization, though they have not attracted as much attention. Likewise, all common types of mass analyzers have been realized by microfabrication and, in most cases, successfully applied to MS analysis in conjunction with on-chip ionization. This review summarizes the latest achievements in the field of microfabricated ion sources and mass analyzers. Representative applications are reviewed focusing on the development of fully microfabricated systems where ion sources or analyzers are integrated with microfluidic separation devices or microfabricated pums and detectors, respectively. Also the main microfabrication methods, with their possibilities and constraints, are briefly discussed together with the most commonly used materials.

show abstract

“…Most common filter types have been fabricated using MEMS techniques. These include crossed-field [60][61][62] and travelling wave [63][64][65] filters, time-of-flight analyzers [66][67][68][69], cylindrical ion traps 75] and linear [76][77][78][79][80] ion traps. However, quadrupole filters have so far offered the best performance, in terms of mass range and mass resolution.…”

Section: Introductionmentioning

confidence: 99%

MEMS-Based Nanospray-Ionization Mass Spectrometer

Wright¹,

Syms

Moseley³

et al. 2010

J. Microelectromech. Syst.

View full text Add to dashboard Cite

An electrospray ionisation mass spectrometer (ESI-MS) whose main components are all fabricated using silicon microelectromechanical systems (MEMS) techniques is demonstrated for the first time. The ion source consists of a microengineered alignment bench containing a V-groove mounting for a nanospray capillary, an ion extraction electrode, and a pneumatic nebuliser. The vacuum interface consists of two plates, each carrying a 50 µm diameter capillary, that are selectively etched and bonded together to provide a differentially pumped internal cavity. The quadrupole filter consists of a microfabricated frame that provides mountings for stainless steel rods measuring 650 µm in diameter and 30 mm in length. Two different quadrupoles are compared: a firstgeneration bonded silicon device, and a second-generation silicon-on-glass device with a Brubaker prefilter. Differential pumping of a MEMS component is demonstrated for the first time, atmospheric pressure ionisation and ion transfer into vacuum are characterised, ESI-MS operation is demonstrated and spectra are presented for a variety of compounds. KEYWORDS:Mass spectrometry, Electrospray, Quadrupole filter, MEMS IntroductionOver 25 years have passed since an electrospray ionisation (ESI) source was first coupled to a quadrupole mass spectrometer (MS) by Yamashita and Fenn [1]. Since then, ESI-MS has become a workhorse of analytical chemistry, allowing analytes to be ionised at atmospheric pressure with little fragmentation and passed into a vacuum system for analysis.Conventional ESI sources employ spray tips with an internal diameter (ID) of ≈100 µm[2]. In order to establish a Taylor cone and maintain stable emission of charged droplets, minimum flow rates of 0.5 -5 µL min -1 and voltages of 2.5 -4 kV are used. However, it has been convincingly demonstrated that high sensitivity and stable emission can be achieved at much lower flow rates and voltages using spray tips with IDs of ≈ 5 µm, and silica nanospray capillaries with a range of coatings have become widely available [3][4][5][6][7][8].Unfortunately, while these are inexpensive, operator expertise and costly positioning apparatus are often required for stable and reproducible performance.Electrosprayed ions are passed into a low-pressure chamber via a vacuum interface. The simplest interface is a single orifice or capillary that allows gas and entrained ions to pass directly into the vacuum chamber. Clearly, the orifice must be small enough or the pumps large enough to ensure that the pressure is consistent with mass analysis. However, the susceptibility of very small orifices to clogging and the inconvenience of large pumps led to this approach being abandoned. Modern instruments employ one or more stages of 4 differential pumping. Larger orifices can be tolerated since only a fraction of the flow is transmitted to the vacuum chamber, while the majority of the gas load can be pumped away at higher pressure using more modest pumps.The effective transfer of ions and molecules from atmospheric pressu...

show abstract

Polymer-Based Ion Trap Chemical Sensor

Cited by 23 publications

References 20 publications

Paper spray ionization devices for direct, biomedical analysis using mass spectrometry

Paper spray ionization devices for direct, biomedical analysis using mass spectrometry

Microchip technology in mass spectrometry

MEMS-Based Nanospray-Ionization Mass Spectrometer

Contact Info

Product

Resources

About