Polymer-based biomaterials for chronic wound management: Promises and challenges

Arif, Muhammad Maaz; Khan, Shahzad Maqsood; Gull, Nafisa; Tabish, Tanveer A.; Zia, Saba; Khan, Rafi Ullah; Awais, Sayed Muhammad; Butt, Muhammad Arif

doi:10.1016/j.ijpharm.2021.120270

Cited by 75 publications

(29 citation statements)

References 96 publications

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“…Inflammation is described as an interaction of pro-and anti-inflammatory cytokines. Usually, chronic wounds have high levels of pro-inflammatory cytokines and underlying infections, conditions that self-sustain each other over long times, thus impeding the second phase of the healing process [53,54]. We showed that all the produced PHA fibers, either incorporating or not OLE, were able to strongly and persistently downregulate of hundredfold differences the expression of all the above cited ILs, with respect to the basal conditions of HaCaT cells in conventional culture.…”

Section: Discussionmentioning

confidence: 81%

Immunomodulatory Activity of Electrospun Polyhydroxyalkanoate Fiber Scaffolds Incorporating Olive Leaf Extract

et al. 2021

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Olive tree is a well-known source of polyphenols. We prepared an olive leaf extract (OLE) and characterized it via high performance liquid chromatography (HPLC) analysis. OLE was blended with different polyhydroxyalkanoates (PHAs), namely, poly(hydroxybutyrate-co-hydroxyvalerate) (PHBHV) and polyhydroxybutyrate/poly(hydroxyoctanoate-co-hydroxydecanoate) (PHB/PHOHD), to produce fiber meshes via electrospinning: OLE/PHBV and OLE/ (PHB/PHOHD), respectively. An 80–90% (w/w%) release of the main polyphenols from the OLE/PHA fibers occurred in 24 h, with a burst release in the first 30 min. OLE and the produced fiber meshes were assayed using human dermal keratinocytes (HaCaT cells) to evaluate the expression of a panel of cytokines involved in the inflammatory process and innate immune response, such as the antimicrobial peptide human beta defensin 2 (HBD-2). Fibers containing OLE were able to decrease the expression of the pro-inflammatory cytokines at 6 h up to 24 h. All the PHA fibers allowed an early downregulation of the pro-inflammatory cytokines in 6 h, which is suggestive of a strong anti-inflammatory activity exerted by PHA fibers. Differently from pure OLE, PHB/PHOHD fibers (both with and without OLE) upregulated the expression of HBD-2. Our results showed that PHA fiber meshes are suitable in decreasing pro-inflammatory cytokines and the incorporation of OLE may enable indirect antibacterial properties, which is essential in wound healing and tissue regeneration.

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Section: Discussionmentioning

confidence: 81%

Immunomodulatory Activity of Electrospun Polyhydroxyalkanoate Fiber Scaffolds Incorporating Olive Leaf Extract

et al. 2021

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“…Furthermore, novel therapies such as magnetic fields have been employed and show great potential in promoting wound healing and have already been utilized in the management of diabetic wounds [39]. The potential of polymeric wound dressing has also been evaluated in wound care management [40]. In addition, improvements in hydrogel dressings have enabled advancements for wound healing [41].…”

Section: Discussionmentioning

confidence: 99%

A Novel Bathing Therapeutic Approach for Diabetic Foot Ulcers

et al. 2021

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Ineffective healing and treatment of foot ulcers can lead to an infection and gangrene of the wound area that ultimately results in the loss of the limb. The incidence of foot ulcers is higher in patients with diabetes, peripheral vascular disease and kidney disease. Accordingly, this study was undertaken to assess the ability of foot bathing in CO2-enriched water to heal foot ulcers. The design was a double-blinded, randomized, placebo-controlled study. Patients with at least one foot ulcer were randomized to receive either a treatment with bath therapy at 37 ± 0.5 °C containing either 1000–1200 ppm CO2-enriched tap water (the intervention) or non-carbonated tap water at 37 ± 0.5 °C (the control group). Treatment was conducted three times/week for 15 min per session for up to 16 weeks for a total of 48 treatment sessions. Before and at the end of every treatment month, wound size, wound area oxygenation and the ankle brachial index were measured. In addition, the McGill pain questionnaire was conducted. Blood was also collected at these time points (for a total of five collections) for the measurement of different biomarkers. While no significant differences (p < 0.05) in the group/time interaction effect were observed, a clear separation within the wound area reduction/wound area/oxygenated Hb outcomes was seen between placebo (control) and treatment (CO2) group. This pilot study is suggestive that bathing in CO2-enriched water may accelerate the healing of foot ulcers.

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“…The chronic wound has been assigned as a major public health problem associated with very high economic costs, representing 2–4% of the total health system costs in the West ( Magin et al, 2016 ; Rodrigues et al, 2019 ; Azevedo et al, 2020 ). Maaz Arif et al( 2021 ) and Kielo-Viljamaa et al (2021 ) reported that approximately 1–2% of the population in the developed countries suffers from chronic wound. As has been explained by other authors, the hindered closure of nonhealing (chronic) wounds (namely pressure ulcer, static venous ulcer, and diabetic wounds, etc.)…”

Section: Introductionmentioning

confidence: 99%

Genipin-Crosslinking Effects on Biomatrix Development for Cutaneous Wound Healing: A Concise Review

Nike

Fadilah

Sallehudin

et al. 2022

Front. Bioeng. Biotechnol.

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Split skin graft (SSG), a standard gold treatment for wound healing, has numerous limitations such as lack of fresh skin to be applied, tedious process, severe scarring, and keloid formation followed by higher risks of infection. Thus, there is a gap in producing polymeric scaffolds as an alternative for wound care management. Bioscaffold is the main component in tissue engineering technology that provides porous three-dimensional (3D) microarchitecture for cells to survive. Upon skin tissue reconstruction, the 3D-porous structure ensures sufficient nutrients and gaseous diffusion and cell penetration that improves cell proliferation and vascularization for tissue regeneration. Hence, it is highly considered a promising candidate for various skin wound healing applications. To date, natural-based crosslinking agents have been extensively used to tailor the physicochemical and mechanical properties of the skin biomatrix. Genipin (GNP) is preferable to other plant-based crosslinkers due to its biological activities, such as antiinflammatory and antioxidant, which are key players to boost skin wound healing. In addition, it has shown a noncytotoxic effect and is biocompatible with human skin cells. This review validated the effects of GNP in biomatrix fabrication for skin wound healing from the last 7 years of established research articles and stipulated the biomaterial development-scale point of view. Lastly, the possible role of GNP in the skin wound healing cascade is also discussed. Through the literature output, it can be concluded that GNP has the capability to increase the stability of biomatrix and maintain the skin cells viability, which will contribute in accelerating wound healing.

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Polymer-based biomaterials for chronic wound management: Promises and challenges

Cited by 75 publications

References 96 publications

Immunomodulatory Activity of Electrospun Polyhydroxyalkanoate Fiber Scaffolds Incorporating Olive Leaf Extract

Immunomodulatory Activity of Electrospun Polyhydroxyalkanoate Fiber Scaffolds Incorporating Olive Leaf Extract

A Novel Bathing Therapeutic Approach for Diabetic Foot Ulcers

Genipin-Crosslinking Effects on Biomatrix Development for Cutaneous Wound Healing: A Concise Review

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