Polyinosinic-Cytidylic Acid Complex (Poly I:G) and Viral Infections in Mice

Lindh, H. F.; Lindsay, H. L.; Mayberry, B. R.; Forbes, M.

doi:10.3181/00379727-132-34153

Cited by 32 publications

(13 citation statements)

References 2 publications

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“…3) conferred significant protection when applied several days after intranasal VSV challenge. However, intraperitoneal (poly rI) * (poly rC), 1 day after virus inoculation, did not decrease the lethal effect of a subcutaneous Columbia SK virus infection (11). Against intranasally inoculated influenza virus, intranasal (poly rI) * (poly rC) was active, whereas intraperitoneal or intravenous (poly rI) - not (11).…”

Section: Resultsmentioning

confidence: 99%

“…Protection at a distant site has also been demonstrated for MA/DVE, (poly rI) . (poly rC), and related synthetic polyanions in other acute viral infections such as vaccinia tail lesions in the mouse (6-9,1 3), herpes simplex infection of the rabbit eye (10), and lethal infections with Columbia SK virus (9,11), encephalomyocarditis virus (12), influenza virus,' and foot and mouth disease in mice (13). Additional support for the role of interferon in the protection observed in these model infections came from the finding that antiviral protection was 'Claes, P., A.…”

Section: Introductionmentioning

confidence: 99%

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The role of interferon in the protective effect of a synthetic double-stranded polyribonucleotide against intranasal vesicular stomatitis virus challenge in mice

Clerco¹,

Nuwer²,

Merigan³

1970

J. Clin. Invest.

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A B S T R A C T Intravenous injection of polyinosinic acid/polycytidylic acid [(poly rI) * (poly rC)] offered significant protection against intranasal challenge of young mice with vesicular stomatitis virus (VSV). Optimal protection was obtained when a single dose was administered 2 hr before virus challenge, but repeated doses were effective when started as late as 3 days after virus challenge. The therapeutic ratio or ratio of maximum tolerated dose to minimum effective dose for a single intravenous injection of (poly rI) *(poly rC) 2 hr before virus inoculation was > 8 mg/kg: 0.004 mg/ kg or > 200. Dose-response curves for interferon production and antiviral protection by (poly rI) -(poly rC) were closely parallel. Equivalent doses of poly rI or poly rC alone did not exert any interferon-inducing capacity or protective effect on intranasal VSV challenge. Several factors, which are known to potentiate or antagonize interferon production, increased or decreased the interferon-inducing capacity and antiviral protection of either (poly rI) * (poly rC) or maleic acid/divinyl ether copolymer (MA/DVE) in parallel. Interferon production and antiviral protection by MA/DVE were enhanced by arginine but abolished by prior treatment with MA/DVE; DEAE-dextran (intraperitoneally), kinetin riboside and isopentenyladenosine, and prior injection of endotoxin reduced both interferon production and antiviral protection by (poly rI) -(poly rC).Treatment with exogenous interferon in amounts which closely mimicked the levels of circulating interferon produced endogenously by an effective dose of (poly rI) * (poly rC) gave protection against intranasal

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The role of interferon in the protective effect of a synthetic double-stranded polyribonucleotide against intranasal vesicular stomatitis virus challenge in mice

Clerco¹,

Nuwer²,

Merigan³

1970

J. Clin. Invest.

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“…In vivo studies with influenza virus strains, including A2/Hong Kong, in mice have not demonstrated a remarkable effect of poly I.C. in preventing infection (15,16). It is difficult to correlate these findings with those in the baboon, however, because effectiveness of poly I.C.…”

Section: Isolation Of Viruses Indigenous T O the Baboonmentioning

confidence: 94%

Persistence and Spread of Influenza Virus (A2/Hong Kong) in Normal and Poly I.C. Treated Baboons (Papio cynocephalus)

Heberling

Kalter

1970

Experimental Biology and Medicine

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“…Poly-I-Poly-C, and to a lesser extent DEAE-dextran, seems to exert a direct inhibitory action on DNA synthesis (Levy, 1970;Serota & Baserga, 1970). The usefulness of interferon, or of the synthetic inducers, has been demonstrated against many viruses, including herpes (Cantell & Tommila, 1960;Jones, Galbraith & Al-Hussaini, 1962;Park & Baron, 1968;Lindh et al, 1969;De Clercq & Merigan, 1970b;Kruger & Mayer, 1970). Its protective activity in experimental herpes encephalitis has been demonstrated by Catalano & Baron (1969).…”

Section: Interferonsmentioning

confidence: 97%

Management of acute necrotizing encephalitis: a review of 369 cases

Rappel¹

1973

Postgraduate Medical Journal

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Polyinosinic-Cytidylic Acid Complex (Poly I:G) and Viral Infections in Mice

Cited by 32 publications

References 2 publications

The role of interferon in the protective effect of a synthetic double-stranded polyribonucleotide against intranasal vesicular stomatitis virus challenge in mice

The role of interferon in the protective effect of a synthetic double-stranded polyribonucleotide against intranasal vesicular stomatitis virus challenge in mice

Persistence and Spread of Influenza Virus (A2/Hong Kong) in Normal and Poly I.C. Treated Baboons (Papio cynocephalus)

Management of acute necrotizing encephalitis: a review of 369 cases

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