Persistence and Spread of Influenza Virus (A2/Hong Kong) in Normal and Poly I.C. Treated Baboons (Papio cynocephalus)

Heberling, R. L.; Kalter, S. S.

doi:10.3181/00379727-135-35128

Cited by 13 publications

(5 citation statements)

References 5 publications

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“…Serological conversions occurred in experimentally infected (A2/Hong Kong/68) and noninfected control contact baboons (193). Heberling and Kalter (127) demonstrated that treatment of influenzainoculated baboons with poly-IC resulted in a delay or supression of antibody. Antibody formation was prevented in uninoculated control contact animals.…”

Section: Myxovirusesmentioning

confidence: 99%

Comparative virology of primates.

Kalter¹,

Heberling²

1971

Bacteriological Reviews

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1 WHO Collaborating Laboratory on Comparative Medicine: Simian Viruses. were listed by The Science Information Exchange of the Smithsonian Institution for fiscal year 1967 at a cost of approximately $55,000,000. Augmented usage of various monkeys and apes may be anticipated for the future, as evidenced by the yearly increase in numbers employed in an attempt to comply with requests by laboratories and by development of additional major primate research centers throughout the world. Breeding programs are anticipated to limit the numbers of animals eventually imported, but such efforts will 310

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Section: Myxovirusesmentioning

confidence: 99%

Comparative virology of primates.

Kalter¹,

Heberling²

1971

Bacteriological Reviews

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“…In fact the litterature on the in vivo effect of interferon and interferon inducers on influenza virus infection is to a large extent self contradictory. Some authors reported that such a treatment to a variable extent reduced growth of influenza virus in the lungs, reduced mortality and seroconversion (14,16,17,20,21,25). Others have not been able to influence the development of experimental influenza infection (8), while in in vitro organ culture preparations even small amounts of IF reduced the growth of influenza virus (6).…”

Section: Discussionmentioning

confidence: 99%

Preventive Effect of a Nonviral Interferon Inducer, a Bacterial Vaccine, On Experimental Influenza In Mice

Dahl

Degré

1972

Acta Pathologica Microbiologica Scandinavica Section B Microbio

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Intranasally inoculated Influenza A2/Singapore virus in mice results in a pulmonary infection with dose depending mortality. This experimental model was employed to study the effect of standard bacterial vaccine (SBV) on viral respiratory infection. SBV, given intraperitoneally from simultaneously to 6 hours before influenza inoculation, reduced the mortality, the growth of virus in the lungs, the development of gross pulmonary lesions and the seroconversion. The protection appeared to be most effective, when the vaccine was given 5 hours prior to viral infection. In some experiments some protection was afforded even with 24 hours or 7 days interval between administration of SBV and virus. The possible mechanism of protection is discussed. SBV given i.p. stimulates production or release of interferon (IF). Our data do not allow any conclusion, whether the effect is due to production of IF or to stimulation of the immune apparatus and other nonspecific mechanisms. Probably both factors are involved.

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“…In a further study, the authors employed baboons to determine if the response to influenza virus infection could be modified by treatment with the recently developed polyribosinic acid complex, polyIC, which appeared to act as an interferon inducer (Heberling and Kalter, 1970). Untreated animals remained well or showed a slight nasal discharge, and all developed antibodies to the virus, while animals given polyIC at the time of virus challenge remained well and showed no antibody response, indicating suppression of viral replication.…”

Section: Experimental Infections Of Nhps With Human Influenza VImentioning

confidence: 99%

“…In the first such report, Heberling and Kalter showed that treatment of baboons with the novel interferon inducer, polyIC, at the time of challenge with an H3N2 virus increased their resistance to infection and prevented transmission of the virus to co-housed animals (Heberling and Kalter, 1970). …”

Section: Experimental Infections Of Nhps With Human Influenza VImentioning

confidence: 99%

The use of nonhuman primates in research on seasonal, pandemic and avian influenza, 1893–2014

2015

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Attempts to reproduce the features of human influenza in laboratory animals date from the early 1890s, when Richard Pfeiffer inoculated apes with bacteria recovered from influenza patients and produced a mild respiratory illness. Numerous studies employing nonhuman primates (NHPs) were performed during the 1918 pandemic and the following decade. Most used bacterial preparations to infect animals, but some sought a filterable agent for the disease. Since the viral etiology of influenza was established in the early 1930s, studies in NHPs have been supplemented by a much larger number of experiments in mice, ferrets and human volunteers. However, the emergence of a novel swine-origin H1N1 influenza virus in 1976 and the highly pathogenic H5N1 avian influenza virus in 1997 stimulated an increase in NHP research, because these agents are difficult to study in naturally infected patients and cannot be administered to human volunteers. In this paper, we review the published literature on the use of NHPs in influenza research from 1893 through the end of 2014. The first section summarizes observational studies of naturally occurring influenza-like syndromes in wild and captive primates, including serologic investigations. The second provides a chronological account of experimental infections of NHPs, beginning with Pfeiffer’s study and covering all published research on seasonal and pandemic influenza viruses, including vaccine and antiviral drug testing. The third section reviews experimental infections of NHPs with avian influenza viruses that have caused disease in humans since 1997. The paper concludes with suggestions for further studies to more clearly define and optimize the role of NHPs as experimental animals for influenza research.

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Persistence and Spread of Influenza Virus (A2/Hong Kong) in Normal and Poly I.C. Treated Baboons (Papio cynocephalus)

Cited by 13 publications

References 5 publications

Comparative virology of primates.

Comparative virology of primates.

Preventive Effect of a Nonviral Interferon Inducer, a Bacterial Vaccine, On Experimental Influenza In Mice

The use of nonhuman primates in research on seasonal, pandemic and avian influenza, 1893–2014

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