Polyhydroxyalkanoates: Trends and advances toward biotechnological applications

Kalia, Vipin Chandra; Patel, Sanjay; Shanmugam, Ramasamy; Lee, Jung-Kul

doi:10.1016/j.biortech.2021.124737

Cited by 124 publications

(56 citation statements)

References 129 publications

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“…In developed countries, no more than 16–18% of plastic waste is recycled [ 5 ]. It is mostly landfilled, posing a global environmental problem [ 6 , 7 ], causing large-scale pollution, upsetting the stability and disrupting the structure of natural ecosystems, and threatening human health [ 8 ]. That is why it is important to research and develop biodegradable plastics as an alternative to synthetic materials [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Laser Processing of Polymer Films Fabricated from PHAs Differing in Their Monomer Composition

et al. 2021

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The study reports results of using a CO2-laser in continuous wave (3 W; 2 m/s) and quasi-pulsed (13.5 W; 1 m/s) modes to treat films prepared by solvent casting technique from four types of polyhydroxyalkanoates (PHAs), namely poly-3-hydroxybutyrate and three copolymers of 3-hydroxybutyrate: with 4-hydroxybutyrate, 3-hydroxyvalerate, and 3-hydroxyhexanoate (each second monomer constituting about 30 mol.%). The PHAs differed in their thermal and molecular weight properties and degree of crystallinity. Pristine films differed in porosity, hydrophilicity, and roughness parameters. The two modes of laser treatment altered these parameters and biocompatibility in diverse ways. Films of P(3HB) had water contact angle and surface energy of 92° and 30.8 mN/m, respectively, and average roughness of 144 nm. The water contact angle of copolymer films decreased to 80–56° and surface energy and roughness increased to 41–57 mN/m and 172–290 nm, respectively. Treatment in either mode resulted in different modifications of the films, depending on their composition and irradiation mode. Laser-treated P(3HB) films exhibited a decrease in water contact angle, which was more considerable after the treatment in the quasi-pulsed mode. Roughness parameters were changed by the treatment in both modes. Continuous wave line-by-line irradiation caused formation of sintered grooves on the film surface, which exhibited some change in water contact angle (76–80°) and reduced roughness parameters (to 40–45 mN/m) for most films. Treatment in the quasi-pulsed raster mode resulted in the formation of pits with no pronounced sintered regions on the film surface, a more considerably decreased water contact angle (to 67–76°), and increased roughness of most specimens. Colorimetric assay for assessing cell metabolic activity (MTT) in NIH 3T3 mouse fibroblast culture showed that the number of fibroblasts on the films treated in the continuous wave mode was somewhat lower; treatment in quasi-pulsed radiation mode caused an increase in the number of viable cells by a factor of 1.26 to 1.76, depending on PHA composition. This is an important result, offering an opportunity of targeted surface modification of PHA products aimed at preventing or facilitating cell attachment.

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Section: Introductionmentioning

confidence: 99%

Laser Processing of Polymer Films Fabricated from PHAs Differing in Their Monomer Composition

et al. 2021

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“…Poly(3-hydroxybutyrate) (P(3-HB)) is the most common PHA, which is produced and accumulated intracellularly by various kinds of microorganisms as carbon and energy sources under the nutrient limitation [ 11 ]. The P(3-HB) is currently serving as an attractive bioplastic that can be applied in various research fields including polymer blends, nanocomposites, food packaging films and biomedical materials due to being fully biodegradable and biocompatible [ 12 , 13 ]. Additionally, several authors reported that P(3-HB) can be used as a bio-based coating to improve surface hydrophobicity and mechanical properties of papers or paper board [ 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Biosynthesized Poly(3-Hydroxybutyrate) on Coated Pineapple Leaf Fiber Papers for Biodegradable Packaging Application

et al. 2021

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This paper is aimed at investigating the usage of biosynthesized poly(3-hydroxybutyrate) (P(3-HB)) for a coating on pineapple leaf fiber paper (PLFP). For this purpose, (P(3-HB)) was produced by Rhodococcus pyridinivorans BSRT1-1, a highly potential P(3-HB) producing bacterium, with a weight-average molecular weight (Mw) of 6.07 × 10 −5 g/mol. This biosynthesized P(3-HB) at 7.5% (w/v) was then coated on PLFP through the dip-coating technique with chloroform used as a solvent. The respective coated PLFP showed that P(3-HB) could be well coated all over on the PLFP surface as confirmed by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. The brightness and mechanical properties of PLFP could be improved by coating with biosynthesized P(3-HB) in comparison to commercially available P(3-HB) and non-coated PLFP. Furthermore, coating of P(3-HB) significantly increased the water drop penetration time on the surface of PLFP and was similar to that of the commercial P(3-HB) with the same content. The results showed that all the coated PLPF samples can be degraded under the soil burial test conditions. We have demonstrated that the P(3-HB) coated PLFP paper has the ability to prevent water drop penetration and could undergo biodegradation. Taken together, the P(3-HB) coated PLFP can be applied as a promising biodegradable paper packaging.

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“…Nowadays, there are many polymers such as natural or synthetic polymers, biodegradable polymers, liposomes, cyclodextrins, DNA, etc. These abundant organic materials provide reliable support for different applications of AMPs ( Martin-Serrano et al, 2019 ; Patel et al, 2019b ; Kalia et al, 2021 ). Here, a summary of the current situation of the organic material nanosystems containing AMPs was given, with particular emphasis on related biological effects of AMP-containing formulations and the interactions of the inner systems.…”

Section: Organic Materials Nanosystems Containing Antimicrobial Peptidesmentioning

confidence: 99%

Nanostructured Antimicrobial Peptides: Crucial Steps of Overcoming the Bottleneck for Clinics

Yang

et al. 2021

Front. Microbiol.

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The security issue of human health is faced with dispiriting threats from multidrug-resistant bacteria infections induced by the abuse and misuse of antibiotics. Over decades, the antimicrobial peptides (AMPs) hold great promise as a viable alternative to treatment with antibiotics due to their peculiar antimicrobial mechanisms of action, broad-spectrum antimicrobial activity, lower drug residue, and ease of synthesis and modification. However, they universally express a series of disadvantages that hinder their potential application in the biomedical field (e.g., low bioavailability, poor protease resistance, and high cytotoxicity) and extremely waste the abundant resources of AMP database discovered over the decades. For all these reasons, the nanostructured antimicrobial peptides (Ns-AMPs), based on a variety of nanosystem modification, have made up for the deficiencies and pushed the development of novel AMP-based antimicrobial therapies. In this review, we provide an overview of the advantages of Ns-AMPs in improving therapeutic efficacy and biological stability, reducing side effects, and gaining the effect of organic targeting and drug controlled release. Then the different material categories of Ns-AMPs are described, including inorganic material nanosystems containing AMPs, organic material nanosystems containing AMPs, and self-assembled AMPs. Additionally, this review focuses on the Ns-AMPs for the effect of biological activities, with emphasis on antimicrobial activity, biosecurity, and biological stability. The “state-of-the-art” antimicrobial modes of Ns-AMPs, including controlled release of AMPs under a specific environment or intrinsic antimicrobial properties of Ns-AMPs, are also explicated. Finally, the perspectives and conclusions of the current research in this field are also summarized.

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Polyhydroxyalkanoates: Trends and advances toward biotechnological applications

Cited by 124 publications

References 129 publications

Laser Processing of Polymer Films Fabricated from PHAs Differing in Their Monomer Composition

Laser Processing of Polymer Films Fabricated from PHAs Differing in Their Monomer Composition

Biosynthesized Poly(3-Hydroxybutyrate) on Coated Pineapple Leaf Fiber Papers for Biodegradable Packaging Application

Nanostructured Antimicrobial Peptides: Crucial Steps of Overcoming the Bottleneck for Clinics

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