Polyhydroxyalkanoates (PHA): Microbial Synthesis of Natural Polyesters

Koller, Martin; Mukherjee, Anindya; Obruča, Stanislav; Zinn, Manfred

doi:10.1007/978-3-031-06600-9_8

Cited by 6 publications

(4 citation statements)

References 167 publications

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“…1.1.1.36), generating R-3-hydroxybutyryl-CoA, the substrate for PHA synthase (polymerase) enzymes (E.C. 2.3.1.304), which link the individual R-3-hydroxybutyryl-CoA building blocks to form polymeric PHA chains in vivo [31]. Therefore, the catalysts needed for PHA biosynthesis (the enzymes) match Principle 9 of Green Chemistry, which says: new catalysts shall be non-toxic, selective, and efficient [23].…”

Section: Biosynthesis Of Pha In Natural Strains Occurs Via Natural Bi...mentioning

confidence: 99%

Microbial PolyHydroxyAlkanoate (PHA) Biopolymers—Intrinsically Natural

Mukherjee

Koller

2023

Bioengineering

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Global pollution from fossil plastics is one of the top environmental threats of our time. At their end-of-life phase, fossil plastics, through recycling, incineration, and disposal result in microplastic formation, elevated atmospheric CO2 levels, and the pollution of terrestrial and aquatic environments. Current regional, national, and global regulations are centered around banning plastic production and use and/or increasing recycling while ignoring efforts to rapidly replace fossil plastics through the use of alternatives, including those that occur in nature. In particular, this review demonstrates how microbial polyhydroxyalkanoates (PHAs), a class of intrinsically natural polymers, can successfully remedy the fossil and persistent plastic dilemma. PHAs are bio-based, biosynthesized, biocompatible, and biodegradable, and thus, domestically and industrially compostable. Therefore, they are an ideal replacement for the fossil plastics pollution dilemma, providing us with the benefits of fossil plastics and meeting all the requirements of a truly circular economy. PHA biopolyesters are natural and green materials in all stages of their life cycle. This review elaborates how the production, consumption, and end-of-life profile of PHAs are embedded in the current and topical, 12 Principles of Green Chemistry, which constitute the basis for sustainable product manufacturing. The time is right for a paradigm shift in plastic manufacturing, use, and disposal. Humankind needs alternatives to fossil plastics, which, as recalcitrant xenobiotics, contribute to the increasing deterioration of our planet. Natural PHA biopolyesters represent that paradigm shift.

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Section: Biosynthesis Of Pha In Natural Strains Occurs Via Natural Bi...mentioning

confidence: 99%

Microbial PolyHydroxyAlkanoate (PHA) Biopolymers—Intrinsically Natural

Mukherjee

Koller

2023

Bioengineering

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“…Roughly 40% of all prokaryotic strains are able to produce hydroxyalkanoate (HA) monomers and more than 150 HA are currently known, these are accumulated in the cell under nitrogen-limiting conditions as a form of carbon stock. 399 The drawback of microbial PHA synthesis is the necessity of cell lysis for their extraction. VFA are the precursors of PHA, thus they can be obtained by CO 2 reduction as a primary source.…”

Section: Acsmentioning

confidence: 99%

Advanced Electroanalysis for Electrosynthesis

Brachi,

El Housseini,

Beaver

et al. 2023

ACS Org. Inorg. Au

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Electrosynthesis is a popular, environmentally friendly substitute for conventional organic methods. It involves using charge transfer to stimulate chemical reactions through the application of a potential or current between two electrodes. In addition to electrode materials and the type of reactor employed, the strategies for controlling potential and current have an impact on the yields, product distribution, and reaction mechanism. In this Review, recent advances related to electroanalysis applied in electrosynthesis were discussed. The first part of this study acts as a guide that emphasizes the foundations of electrosynthesis. These essentials include instrumentation, electrode selection, cell design, and electrosynthesis methodologies. Then, advances in electroanalytical techniques applied in organic, enzymatic, and microbial electrosynthesis are illustrated with specific cases studied in recent literature. To conclude, a discussion of future possibilities that intend to advance the academic and industrial areas is presented.

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“…PHAs are a series of structurally diverse storage polyesters that are accumulated by various bacterial species and stored intracellularly in the form of granules [ 26 ]. They primarily act as carbon and energy storage compounds to sustain cell survival during starvation [ 27 ]. In 1926, Lemoigne [ 28 ] first discovered these biological polymers.…”

Section: Overview Of Phasmentioning

confidence: 99%

Exploring the Feasibility of Cell-Free Synthesis as a Platform for Polyhydroxyalkanoate (PHA) Production: Opportunities and Challenges

et al. 2023

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The extensive utilization of traditional petroleum-based plastics has resulted in significant damage to the natural environment and ecological systems, highlighting the urgent need for sustainable alternatives. Polyhydroxyalkanoates (PHAs) have emerged as promising bioplastics that can compete with petroleum-based plastics. However, their production technology currently faces several challenges, primarily focused on high costs. Cell-free biotechnologies have shown significant potential for PHA production; however, despite recent progress, several challenges still need to be overcome. In this review, we focus on the status of cell-free PHA synthesis and compare it with microbial cell-based PHA synthesis in terms of advantages and drawbacks. Finally, we present prospects for the development of cell-free PHA synthesis.

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Polyhydroxyalkanoates (PHA): Microbial Synthesis of Natural Polyesters

Cited by 6 publications

References 167 publications

Microbial PolyHydroxyAlkanoate (PHA) Biopolymers—Intrinsically Natural

Microbial PolyHydroxyAlkanoate (PHA) Biopolymers—Intrinsically Natural

Advanced Electroanalysis for Electrosynthesis

Exploring the Feasibility of Cell-Free Synthesis as a Platform for Polyhydroxyalkanoate (PHA) Production: Opportunities and Challenges

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