Polyhydroxyalkanoate nanoparticles produced by marine bacteria cultivated on cost effective Mediterranean algal hydrolysate media

El-malek, Fady Abd; Rofeal, Marian; Farag, Aïda M.; Omar, Sanaa H.; Khairy, Heba

doi:10.1016/j.jbiotec.2021.01.008

Cited by 24 publications

(21 citation statements)

References 52 publications

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“…Halophilic bacteria have gained attention as a candidate for PHA synthesis owing to their unique growth conditions that reduces the chances of contamination. Members of the halophilic Halomonadaceae family are able to amass large quantities of PHAs from different carbon sources ( Abd El-Malek et al, 2021 ). Recently, production of biodiesel from microalgae is gaining worldwide attention as it has been shown to be the only renewable biodiesel source able to meet the global demand for transport fuels.…”

Section: Microalgae and Bacterial Pha Synthesismentioning

confidence: 99%

“…H. daqingensis was found to be able to synthesize PHA by utilizing glycerol-rich algal biodiesel waste residue as the sole carbon source ( Dubey and Mishra, 2021 ). Moreover, Halomonas pacifica ASL10 and Halomonas salifodiane successfully produced PHAs from the macroalgae Pterocladia capillaceais and Corallina mediterraneais as well as Arthrospira ( Abd El-Malek et al, 2021 ).…”

Section: Microalgae and Bacterial Pha Synthesismentioning

confidence: 99%

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Microalgal Biomass as Feedstock for Bacterial Production of PHA: Advances and Future Prospects

Tan

Nadir

Sudesh

2022

Front. Bioeng. Biotechnol.

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The search for biodegradable plastics has become the focus in combating the global plastic pollution crisis. Polyhydroxyalkanoates (PHAs) are renewable substitutes to petroleum-based plastics with the ability to completely mineralize in soil, compost, and marine environments. The preferred choice of PHA synthesis is from bacteria or archaea. However, microbial production of PHAs faces a major drawback due to high production costs attributed to the high price of organic substrates as compared to synthetic plastics. As such, microalgal biomass presents a low-cost solution as feedstock for PHA synthesis. Photoautotrophic microalgae are ubiquitous in our ecosystem and thrive from utilizing easily accessible light, carbon dioxide and inorganic nutrients. Biomass production from microalgae offers advantages that include high yields, effective carbon dioxide capture, efficient treatment of effluents and the usage of infertile land. Nevertheless, the success of large-scale PHA synthesis using microalgal biomass faces constraints that encompass the entire flow of the microalgal biomass production, i.e., from molecular aspects of the microalgae to cultivation conditions to harvesting and drying microalgal biomass along with the conversion of the biomass into PHA. This review discusses approaches such as optimization of growth conditions, improvement of the microalgal biomass manufacturing technologies as well as the genetic engineering of both microalgae and PHA-producing bacteria with the purpose of refining PHA production from microalgal biomass.

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Section: Microalgae and Bacterial Pha Synthesismentioning

confidence: 99%

Section: Microalgae and Bacterial Pha Synthesismentioning

confidence: 99%

Microalgal Biomass as Feedstock for Bacterial Production of PHA: Advances and Future Prospects

Tan

Nadir

Sudesh

2022

Front. Bioeng. Biotechnol.

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“…They showed a higher bioavailability when compared to the insulin solution. Poly (3 HV-co-3HB)-based nanoparticles were produced from PHA extracted from microalgae such as Halomonas pacifica ASL10 and H. salifodiane ASL11 showed antibacterial activity against S. aureus ATCC 25,923, and P. aeruginosa ATCC 27,853 [ 250 ]. Both the amoxicillin-loaded MBPNc (microbial biopolyesteric nanocarrier) and the levofoxacin-loaded MBPNc demonstrated a distinct zone of inhibition against E. coli at a concentration of 200 µL, with a diameter of 25 and 24 mm respectively [ 215 ].…”

Section: Applications Of Pha Nanoparticlesmentioning

confidence: 99%

The Synthesis, Characterization and Applications of Polyhydroxyalkanoates (PHAs) and PHA-Based Nanoparticles

et al. 2021

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Polyhydroxyalkanoates (PHAs) are storage granules found in bacteria that are essentially hydroxy fatty acid polyesters. PHA molecules appear in variety of structures, and amongst all types of PHAs, polyhydroxybutyrate (PHB) is used in versatile fields as it is a biodegradable, biocompatible, and ecologically safe thermoplastic. The unique physicochemical characteristics of these PHAs have made them applicable in nanotechnology, tissue engineering, and other biomedical applications. In this review, the optimization, extraction, and characterization of PHAs are described. Their production and application in nanotechnology are also portrayed in this review, and the precise and various production methods of PHA-based nanoparticles, such as emulsion solvent diffusion, nanoprecipitation, and dialysis are discussed. The characterization techniques such as UV-Vis, FTIR, SEM, Zeta Potential, and XRD are also elaborated.

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“…PHAs are biodegradable polyesters with a wide range of building blocks. PHAs became quite attractive, as they have similar thermal and material properties like conventional thermoplastics ( Abd El-malek et al, 2020 ; Abd El-malek et al, 2021 ). Bacterial PHAs are produced from a variety of renewable feedstock and by biological processes such as beer brewery waste, food waste, algal biomass, rice mill effluent, waste frying oil, etc., mostly through fermentation ( El-Malek et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Post-Synthetic Enzymatic and Chemical Modifications for Novel Sustainable Polyesters

El-malek

Steinbüchel

2022

Front. Bioeng. Biotechnol.

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Because of their biodegradability, compostability, compatibility and flexible structures, biodegradable polymers such as polyhydroxyalkanoates (PHA) are an important class of biopolymers with various industrial and biological uses. PHAs are thermoplastic polyesters with a limited processability due to their low heat resistance. Furthermore, due to their high crystallinity, some PHAs are stiff and brittle. These features result sometimes in very poor mechanical characteristics with low extension at break values which limit the application range of some natural PHAs. Several in vivo approaches for PHA copolymer modifications range from polymer production to enhance PHA-based material performance after synthesis. The methods for enzymatic and chemical polymer modifications are aiming at modifying the structures of the polyesters and thereby their characteristics while retaining the biodegradability. This survey illustrates the efficient use of enzymes and chemicals in post-synthetic PHA modifications, offering insights on these green techniques for modifying and improving polymer performance. Important studies in this sector will be reviewed, as well as chances and obstacles for their stability and hyper-production.

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Polyhydroxyalkanoate nanoparticles produced by marine bacteria cultivated on cost effective Mediterranean algal hydrolysate media

Cited by 24 publications

References 52 publications

Microalgal Biomass as Feedstock for Bacterial Production of PHA: Advances and Future Prospects

Microalgal Biomass as Feedstock for Bacterial Production of PHA: Advances and Future Prospects

The Synthesis, Characterization and Applications of Polyhydroxyalkanoates (PHAs) and PHA-Based Nanoparticles

Post-Synthetic Enzymatic and Chemical Modifications for Novel Sustainable Polyesters

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