Polyglycolic Acid, Silk, and Topical Ampicillin

Andersen, Jens Rikardt

doi:10.1001/archsurg.1980.01380030041009

Cited by 22 publications

(3 citation statements)

References 12 publications

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“…The infection rates have been reported previously [6], a total of 3.4% (11/321) with no differences between the groups. No additional cases of wound infection have emerged since the previous publication.…”

Section: Resultssupporting

confidence: 61%

Inguinal hernia repair with silk or polyglycolic acid sutures: A controlled trial with 5‐years' follow‐up

et al. 1983

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Polyglycolic acid and silk sutures were used for repair of 321 direct inguinal hernias in 302 patients in a triple‐blind randomized trial. A standardized McVay repair was used. A total of 28 recurrent hernias were diagnosed. The cumulated recurrence rate increased gradually to 6.5% after 2 years and to 10.4% after 5 years. No difference was found between polyglycolic acid and silk sutures. It is concluded that repair of direct inguinal hernias may be performed with the same safety with polyglycolic acid as with silk sutures.

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Section: Resultssupporting

confidence: 61%

Inguinal hernia repair with silk or polyglycolic acid sutures: A controlled trial with 5‐years' follow‐up

et al. 1983

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“…The benefits of topical antibiotic prophylaxis with various agents have been documented for multiple surgical disciplines, including ophthalmic, orthopedic, neurological, urological, and general surgeries ( 11 – 16 ); however, the evidence for inguinal hernia repair with mesh is limited, as recent PubMed and Google Scholar searches found only four controlled clinical studies ( 5 , 17 – 19 ).…”

Section: Topical Antibiotics In Generalmentioning

confidence: 99%

“…Andersen and colleagues published their experience with topical ampicillin application in patients that underwent McVay repair for inguinal hernias in 1980 ( 17 ). They delivered 1 g of ampicillin powder into the subfascial layers in the test group and recorded a 3.7% wound infection rate, whereas the wound infection rate was 4.0% in the control group.…”

Section: Topical Antibiotics In Generalmentioning

confidence: 99%

Hernia, Mesh, and Topical Antibiotics, Especially Gentamycin: Seeking the Evidence for the Perfect Outcomeâ€¦

Kulaçoğlu

2015

Front. Surg.

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Inguinal hernia repair is a clean surgical procedure and surgical site infection (SSI) rate is generally below 2%. Antibiotic prophylaxis is not routinely recommended, but it may be a good choice for institutions with high rates of wound infection (>5%). Typical prophylaxis is the intravenous application of first or second-generation cephalosporins before the skin incision. However, SSI rate remains more than 2% in many centers in spite of intravenous antibiotic prophylaxis. Even a 1% SSI rate may be unacceptable for the surgeons who specifically deal with hernia surgery. A hernia center targets to be a center of excellence not only in respect of recurrence rate but also for other postoperative outcomes, therefore a further measure is required for an excellent result regarding infection control. Topical gentamycin application in combination with preoperative single-dose intravenous antibiotic may be a useful to obtain this perfect outcome. Data about this subject are not complete and high-grade evidence has not been cumulated yet. Prospective randomized controlled trials can make our knowledge more solid about this subject and help the surgeons who seek perfect outcome regarding infection control in inguinal hernia surgery.

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