Polyglutamic acid-based crosslinked doxorubicin nanogels as an anti-metastatic treatment for triple negative breast cancer

Duro‐Castaño, Aroa; Sousa-Hervés, Ana; Armiñán, Ana; Charbonnier, David; Arroyo‐Crespo, Juan J.; Wedepohl, Stefanie; Calderón, Marcelo; Vicent, Marı́a J.

doi:10.1016/j.jconrel.2021.02.005

Cited by 37 publications

(24 citation statements)

References 66 publications

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“…Nanogel-based chemotherapy can improve the distribution of chemotherapeutic agents and enhance their deposition at the tumour site. 74,75 In addition to chemotherapeutic drug delivery, nanogels can also be used for the delivery of small interfering RNA (siRNA) and macromolecular proteins, such as by encapsulating ribonuclease A (RNase A) and doxycycline (Doc) to synergistically inhibit tumour growth and metastasis. 76,77 As another widely used treatment modality, nanogel-based RT uses X-rays to trigger drug release, which can enhance RT dose deposition and inhibit tumourigenesis when combined with multiple treatment modalities.…”

Section: Preparation and Categories Of Nanogelsmentioning

confidence: 99%

Bioengineered nanogels for cancer immunotherapy

Liu

et al. 2022

Chem. Soc. Rev.

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Section: Preparation and Categories Of Nanogelsmentioning

confidence: 99%

Bioengineered nanogels for cancer immunotherapy

Liu

et al. 2022

Chem. Soc. Rev.

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“…Die Konjugation von PGA an Arzneimittel kann auf verschiedene Weisen erfolgen: Das Krebsmedikament kann über eine Esterbindung [97] oder einen spaltbaren Linker [98] direkt an das Polymer gebunden werden. Alternativ kann PGA in einem einfacheren Prozess aufgrund seiner polyanionischen Eigenschaft einen ionischen Komplex mit einem positiv geladenen Wirkstoff bilden [99] . Es hat sich gezeigt, dass die Linkerchemie einen wichtigen Einfluss auf die biologische Aktivität der Konjugate hat.…”

Section: Polymerkonjugateunclassified

Chemische Ansätze für synthetische Wirkstofftransportsysteme für systemische Anwendungen

et al. 2022

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Schlechte Wasserlöslichkeit und geringe Bioverfügbarkeit von pharmazeutischen Wirkstoffen (APIs) sind die Hauptursache für Verzögerungen in der pharmazeutischen Industrie und stellen eine große Hürde für die Entwicklung neuer Arzneimittel dar. Der Transport von Arzneimitteln ist nach wie vor die größte Herausforderung für die Anwendung niedermolekularer Medikamente und Biopharmazeutika. Die drei Herausforderungen für synthetische Transportsysteme sind: (i) Kontrolle über die Wirkstoffverteilung und Clearance im Blut, (ii) Solubilisierung schlecht wasserlöslicher Wirkstoffe und (iii) selektive Akkumulation in bestimmten Geweben. Obwohl viele Polymer-basierte Systeme die ersten beiden Anforderungen erfüllen und in die klinische Praxis umgesetzt wurden, hat bisher noch kein zielgerichtetes, synthetisches Abgabesystem den Markt erreicht. Dieser Aufsatz soll einen Überblick über die Herausforderungen und Anforderungen zur Entwicklung und Umsetzung neuer Polymer-basierter Darreichungssysteme geben. Hauptaugenmerk liegt hierbei auf den chemischen Ansätzen für die Darreichung von Wirkstoffen für systemische Anwendungen.

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“…Nanogels Nanogels are three-dimensional (3D) hydrogels composed of crosslinkable hydrophilic polymer networks. Structural versatility of nanogels such as inherent porosity and high water retention allows exceptional drug loading capacities (more than 30% weight) owing to their enhanced colloidal and dispersion stabilities compared to other types of polymeric NPs such as micelles and polymersomes [44]. Interestingly, nanogels are unique due to having both hydrogels and NPs characteristics simultaneously, which made them great candidates for selective and targeted anticancer drug delivery.…”

Section: Polymeric Micellesmentioning

confidence: 99%

Development of Polymer-Assisted Nanoparticles and Nanogels for Cancer Therapy: An Update

Neerooa

Ooi

Shameli

et al. 2021

Gels

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With cancer remaining as one of the main causes of deaths worldwide, many studies are undergoing the effort to look for a novel and potent anticancer drug. Nanoparticles (NPs) are one of the rising fields in research for anticancer drug development. One of the key advantages of using NPs for cancer therapy is its high flexibility for modification, hence additional properties can be added to the NPs in order to improve its anticancer action. Polymer has attracted considerable attention to be used as a material to enhance the bioactivity of the NPs. Nanogels, which are NPs cross-linked with hydrophilic polymer network have also exhibited benefits in anticancer application. The characteristics of these nanomaterials include non-toxic, environment-friendly, and variable physiochemical properties. Some other unique properties of polymers are also attributed by diverse methods of polymer synthesis. This then contributes to the unique properties of the nanodrugs. This review article provides an in-depth update on the development of polymer-assisted NPs and nanogels for cancer therapy. Topics such as the synthesis, usage, and properties of the nanomaterials are discussed along with their mechanisms and functions in anticancer application. The advantages and limitations are also discussed in this article.

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Polyglutamic acid-based crosslinked doxorubicin nanogels as an anti-metastatic treatment for triple negative breast cancer

Abstract: acid-based crosslinked doxorubicin nanogels as an anti-metastatic treatment for triple negative breast cancer.

Cited by 37 publications

References 66 publications

Bioengineered nanogels for cancer immunotherapy

Bioengineered nanogels for cancer immunotherapy

Chemische Ansätze für synthetische Wirkstofftransportsysteme für systemische Anwendungen

Development of Polymer-Assisted Nanoparticles and Nanogels for Cancer Therapy: An Update

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