Polygenic risk, family cohesion, and adolescent aggression in Mexican American and European American families: Developmental pathways to alcohol use

Elam, Kit K.; Chassin, Laurie; Pandika, Danielle

doi:10.1017/s0954579418000901

Cited by 41 publications

(26 citation statements)

References 92 publications

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“…Accordingly, the current study capitalizes on advances in molecular genetic techniques by including a polygenic risk score created from a recent meta-GWAS of aggression in middle childhood (Pappa et al, 2016). Based on prior research suggesting that comparable polygenic risk scores based on the aforementioned meta-GWAS are predictive of early-starting CP (Elam, Chassin, & Pandika, 2018), we used a polygenic risk score for aggression to test whether it discriminated higher and more persistent trajectories of CP from early childhood through adolescence.…”

Section: Developmental Transitions: the Toddler Periodmentioning

confidence: 99%

Trajectories and Predictors of Children's Early-Starting Conduct Problems: Child, Family, Genetic, and Intervention Effects

et al. 2019

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AbstractSeveral research teams have previously traced patterns of emerging conduct problems (CP) from early or middle childhood. The current study expands on this previous literature by using a genetically-informed, experimental, and long-term longitudinal design to examine trajectories of early-emerging conduct problems and early childhood discriminators of such patterns from the toddler period to adolescence. The sample represents a cohort of 731 toddlers and diverse families recruited based on socioeconomic, child, and family risk, varying in urbanicity and assessed on nine occasions between ages 2 and 14. In addition to examining child, family, and community level discriminators of patterns of emerging conduct problems, we were able to account for genetic susceptibility using polygenic scores and the study's experimental design to determine whether random assignment to the Family Check-Up (FCU) discriminated trajectory groups. In addition, in accord with differential susceptibility theory, we tested whether the effects of the FCU were stronger for those children with higher genetic susceptibility. Results augmented previous findings documenting the influence of child (inhibitory control [IC], gender) and family (harsh parenting, parental depression, and educational attainment) risk. In addition, children in the FCU were overrepresented in the persistent low versus persistent high CP group, but such direct effects were qualified by an interaction between the intervention and genetic susceptibility that was consistent with differential susceptibility. Implications are discussed for early identification and specifically, prevention efforts addressing early child and family risk.

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Section: Developmental Transitions: the Toddler Periodmentioning

confidence: 99%

Trajectories and Predictors of Children's Early-Starting Conduct Problems: Child, Family, Genetic, and Intervention Effects

et al. 2019

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“…Several articles in this Special Issue focus on cultural genomics, or the numerous ways in which cultural experiences are influenced by, affect, and covary with the genome and the environment to shape behavior and cognition at the social, developmental, and evolutionary levels (Causadias & Korous, 2018; Moya & Henrich, 2016). Using a sample of 479 Mexican American and European American adolescents, Elam, Chassin, and Pandika (2018) examined polygenic risk scores for aggression in evocative gene–environment correlations and family cohesion and alcohol use. More family cohesion was associated with lower levels of alcohol use in early adulthood, and this link was stronger for Mexican American than for European American adolescents.…”

Section: Investigating the Interplay Of Culture And Biology In Develomentioning

confidence: 99%

Cultural development and psychopathology

Causadías

Cicchetti

2018

Dev Psychopathol

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Culture plays a pivotal role in adaptive and maladaptive development. However, culture remains disconnected from theory, research, training, assessment, and interventions in developmental psychopathology, limiting our understanding of the genesis and epigenesis of mental health. Cultural development and psychopathology research can help overcome this limitation by focusing on the elucidation of cultural risk, protective, and promotive factors, at the individual and social levels, that initiate, derail, or maintain trajectories of normal and abnormal behavior. The goal of this Special Issue is to showcase research on the association between culture, development, and psychopathology that investigates equifinality and multifinality in cultural development, the interplay between culture and biology, cultural assessment and interventions, and cultural differences and similarities.

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“…PRSs reflect a person's genetic predisposition for a given phenotype and aggregate information on genetic risk of individual genetic variants estimated from genome-wide association studies (GWAS). Derived from the EAGLE-consortium genome-wide association study of children's aggressive behaviour [13], associations were reported between a PRS for aggressive behaviour (PRSAGG) and behavioural inhibition and negative affectivity in early childhood [14], aggressive behaviour in early adolescence [15], and lifetime incarceration risk in males [16]. Shaw and colleagues [17] examined the role of PRSAGG in distinguishing emerging patterns of conduct problems across childhood in a high-risk intervention sample but failed to find an association.…”

Section: Polygenic Risk For Aggressive Behaviour From Late Childhood mentioning

confidence: 99%

Polygenic risk for aggressive behaviour from late childhood through early adulthood

Kretschmer¹,

Ouellet‐Morin

Vrijen³

et al. 2021

Preprint

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Twin studies suggest a substantial role for genes in explaining individual differences in aggressive behaviour across development. It is unclear, however, how directly measured genetic risk is associated with aggressive behaviour at different moments across adolescence and how genes might distinguish developmental trajectories of aggressive behaviour. Here, a polygenic risk score derived from the EAGLE-Consortium genome-wide association study of aggressive behaviour in children was tested as predictor of latent growth classes derived from those measures in an adolescent population (n = 2229, of which n = 1259 with genetic information) and a high-risk sample (n = 543, of which n = 339 with genetic information). In the population sample, the polygenic risk score explained variation in parent-reported aggressive behaviour at all ages and distinguished between stable low aggressive behaviour and moderate and high-decreasing trajectories based on parent-report. In contrast, the polygenic risk score was not associated with self- and teacher-reported aggressive behaviour, and no associations were found in the high-risk sample. This pattern of results suggests that methodological choices made in genome-wide association studies impact the predictive power of polygenic risk scores, not just with respect to power but likely also in terms of generalizability and specificity.

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Polygenic risk, family cohesion, and adolescent aggression in Mexican American and European American families: Developmental pathways to alcohol use

Cited by 41 publications

References 92 publications

Trajectories and Predictors of Children's Early-Starting Conduct Problems: Child, Family, Genetic, and Intervention Effects

Trajectories and Predictors of Children's Early-Starting Conduct Problems: Child, Family, Genetic, and Intervention Effects

Cultural development and psychopathology

Polygenic risk for aggressive behaviour from late childhood through early adulthood

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